A5100660282- melanin and skin pigmentation
- Skin Protection and Aging
- Liver Disease Diagnosis and Treatment
- Neurotransmitter Receptor Influence on Behavior
- Zebrafish Biomedical Research Applications
- Alkaloids: synthesis and pharmacology
- Cancer-related molecular mechanisms research
- Electrospun Nanofibers in Biomedical Applications
- RNA modifications and cancer
- Biochemical Analysis and Sensing Techniques
- Vitamin C and Antioxidants Research
- Bone Tissue Engineering Materials
- Hair Growth and Disorders
- RNA regulation and disease
- Signaling Pathways in Disease
- Ferroptosis and cancer prognosis
- FOXO transcription factor regulation
- Graphene and Nanomaterials Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Advanced Glycation End Products research
- Glycosylation and Glycoproteins Research
- Wnt/β-catenin signaling in development and cancer
- Prenatal Substance Exposure Effects
Wuhan University
2016-2024
Renmin Hospital of Wuhan University
2016-2024
Tianjin Chest Hospital
2024
Nanjing Medical University
2019-2023
Nanjing Jiangning Hospital
2023
Nantong University
2017-2020
Affiliated Hospital of Nantong University
2018-2019
Southern Medical University
2014-2018
Shanxi Province Hospital of Traditional Chinese Medicine
2016-2017
University of Pennsylvania
2016-2017
Periodontitis is a chronic inflammatory disease induced by biofilm that forms on the tooth surface. Increased periodontal associated with aging. We investigated effect of aging challenge oral pathogens, examining host response, colonization, and osteoclast numbers in aged versus young mice. also compared results mice lineage-specific deletion transcription factor FOXO1, which reduces dendritic cell (DC) function. was inoculation Porphyromonas gingivalis Fusobacterium nucleatum (4 to 5 mo)...
Neutrophils play an essential role in the innate immune response to microbial infection and are particularly important clearing bacterial infection. We investigated of transcription factor FOXO1 neutrophils challenge with Porphyromonas gingivalis vivo vitro. In these experiments, effect lineage-specific deletion LyzM.Cre+FOXO1L/L mice was compared matched littermate controls. negatively affected several critical aspects neutrophil function including mobilization from bone marrow (BM)...
Clinical studies have proven that ultraviolet B (UVB) based phototherapy can induce perifollicular and marginal repigmentation patterns in the skin of vitiligo patients. It is, however, difficult to conceive how melanocytes easily exit from their tightly interconnected epidermal microenvironment re‑enter a different location establish new network with neighboring keratinocytes. While it is known matrix metalloprotease 9 (MMP9) involved degradation extracellular physiological or pathological...
Keratinocyte migration is a key aspect of re-epithelialization during wound healing. Matrix metalloproteinase 9 (MMP9) contributes to this process and deficiencies in the MMP9 lead impaired Inappropriate expression also re-epithelialization. Previously we demonstrated that FOXO1 was activated healing but higher levels diabetic wounds. To address mechanisms examined vivo full thickness dermal scalp wounds created experimental K14.Cre + .Foxo1 L/L mice with lineage-specific Cre recombinase...
Baicalin is a traditional Chinese herbal medicine commonly used for hair loss, the precise molecular mechanism of which unknown. In present study, baicalin was investigated via topical application to reconstituted follicles on mice dorsa and evaluating effect canonical Wnt/β‑catenin signaling in activity dermal papillar cells. The results indicate that stimulates expression Wnt3a, Wnt5a, frizzled 7 disheveled 2 whilst inhibiting Axin/casein kinase 1α/adenomatous polyposis coli/glycogen...
Although vitamin C (VC, L-ascorbic acid) has been widely used as a skin lightening agent for long time, the mechanism by which it inhibits melanogenesis remains poorly understood. It is well-documented that intramelanocytic pH an important factor in regulating tyrosinase function and melanosome maturation. The activity of tyrosinase, rate-limiting enzyme required melanin synthesis, generally minimal acidic environment. Given VC compound, we might speculate intracellular acidification...
Lung cancer is the most common malignant tumor with increasing angiopoietin-2 (Ang-2) and a high rate of metastasis. However, mechanism Ang-2 enhancing proliferation facilitating metastasis remains to be clarified. In this study, expression its gene transcription on effects biological behaviors epithelial-mesenchymal transition (EMT) were investigated in lung cancers. Total incidence cancerous tissues was up 91.8 % (112 122) significantly higher (χ2=103.753, P2=7.883, P=0.005),...
Epigenetic silencing of secreted frizzled-related protein (SFRP) genes, antagonists the WNT pathway, contributes to pathogenesis several cancers including non-small cell lung cancer (NSCLC). We hypothesize that methylation analysis SFRPs family could improve their use as a panel biomarkers for diagnosing and staging NSCLC in China. The expression four SFRP members (SFRP1, 2, 4, 5) samples was screened by RT-PCR quantitative real-time PCR. Only SFRP1 significantly downregulated NSCLC,...
Sinomenine is a nonaddictive alkaloid used to prevent morphine dependence, even thoughits mechanism isnot fully understood. Astrocytes aggravate the pathological process in their neighboring cellsthrough exosomes central nervous system diseases. However, effect of sinomenine on astrocyte-derived for amelioration dependence has not been reported yet. In this study, we found that prevented morphine-induced conditionedplace preference mice. reduced levels cAMP and intracellular Ca2+...
Abstract Background In recent years, natural bone extracellular matrix (ECM)-inspired materials have found widespread application as scaffolds for tissue engineering. However, the challenge of creating that mimic ECM’s mechanical strength and hierarchical nano-micro-macro structures remains. The purposes this study were to introduce an innovative ECM-inspired scaffold integrates a 3D-printed framework with hydroxyapatite (HAp) mineralized graphene oxide-collagen (GO-Col) microscaffolds find...
Prevalence of nonalcoholic fatty liver disease (NAFLD) is rapidly increasing, and NAFLD has become one the most common chronic diseases worldwide. With abnormal CD44 activation, severe form can progress to cirrhosis hepatocellular carcinoma (HCC). Thus, molecular mechanism in needs be identified.To investigate relationship between activation malignant transformation rat hepatocytes under lipid accumulation.Sprague-Dawley rats were fed a high-fat (HF) for 12 wk entice then with HF plus...
Safe and effective ingredients capable of removing undesired hyperpigmentation from facial skin are urgently needed for both pharmaceutical cosmetic purposes. Deoxyarbutin (4-[(tetrahydro-2H-pyran-2-yl) oxy] phenol, D-Arb) is a glucoside derivative hydroquinone. Here, we investigated the toxicity efficacy D-Arb at sub-cellular level (directly on melanosomes) pigmentation using in vivo vitro models to compare with its parent compound hydroquinone (1,4-benzenediol, HQ). At first, examined...
Purpose: High mobility group box 3 (HMGB3) is associated with hepatocytes malignant transformation by our previous work. We continued to investigate the diagnostic and prognostic values of HMGB3 for hepatocellular carcinoma (HCC). Patients methods: Circulating levels were quantitatively detected in a cohort 225 patients chronic liver diseases ELISA compared alpha-fetoprotein receiver operating characteristic curve. expression tissues 170 HCC was tissue microarray immunohistochemistry....
Purpose: This study aims to explore the factors linked occurrence of acute pulmonary thromboembolism (PE) within a cohort patients exhibiting hypoxic saturation (oxygen levels falling below 93%), subsequent undergoing off-pump coronary artery bypass grafting (OPCABG). Methods: A retrospective case-control was conducted. total 296 met inclusion and exclusion criteria, divided into PE group (100 cases) non-PE (196 according whether they had or not. The preoperative postoperative information...
Abstract Background: Increasing evidence indicates that oxidative stress and interferon γ (IFNγ)-driven cellular immune responses are responsible for the pathogenesis of vitiligo. However, connection between local production IFNγ in early vitiligo remains unexplored. The aim this study was to identify mechanism underlying by mast cells its impact on pathogenesis. Methods: Skin specimens from central, marginal, perilesional skin areas active lesions were collected characterize changes cells,...
To explore the relationship between dynamic expression of high mobility group box-3 (HMGB3) and malignant transformation hepatocytes.Expression HMGB family proteins were observed in rat hepatocarcinogenesis models induced with 2-acetylaminofluorene. Alterations HMGB3 analyzed at mRNA level by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) protein immunohistochemistry or Western blotting. human liver cancer tissues evaluated using bioinformatics databases from GEO,...