A5056774287- Oral microbiology and periodontitis research
- Bone Metabolism and Diseases
- Immune Response and Inflammation
- Wound Healing and Treatments
- FOXO transcription factor regulation
- Mesenchymal stem cell research
- Periodontal Regeneration and Treatments
- Bone health and treatments
- Cell Adhesion Molecules Research
- NF-κB Signaling Pathways
- Oral Health Pathology and Treatment
- Bone and Dental Protein Studies
- Salivary Gland Disorders and Functions
- Chemokine receptors and signaling
- Advanced Glycation End Products research
- Proteoglycans and glycosaminoglycans research
- Cytokine Signaling Pathways and Interactions
- Oral and gingival health research
- Endodontics and Root Canal Treatments
- S100 Proteins and Annexins
- Streptococcal Infections and Treatments
- dental development and anomalies
- Circular RNAs in diseases
- Pressure Ulcer Prevention and Management
- Burn Injury Management and Outcomes
University of Pennsylvania
2015-2024
California University of Pennsylvania
2012-2022
University of Minnesota Rochester
2021
Peking University
2008-2015
Philadelphia University
2012-2015
King University
2015
Boston University
2001-2011
Rutgers, The State University of New Jersey
2009-2010
University Hospital, Newark
2008-2009
Boston Medical Center
1991-2008
Abstract Periodontal disease is the most frequent cause of tooth loss in humans and prevalent associated with bone loss, including osteoporosis. destruction initiated by bacteria that colonize surface, leading to inflammation resorption. To assess roles IL-1 TNF this process, studies were conducted a Macaca fascicularis primate model experimental periodontitis. Function-blocking soluble receptors applied local injection sites induced periodontal compared similar injected vehicle alone. The...
Abstract Fracture healing is a unique biological process regulated by complex array of signaling molecules and proinflammatory cytokines. Recent evidence for the role tumor necrosis family members in coupling cellular functions during skeletal homeostasis suggests that they also may be involved regulation repair. The expression number cytokines receptors are functional importance to bone remodeling (osteoprotegerin [OPG], macrophage colony-stimulating factor [M-CSF], osteoprotegerin ligand...
Monocytes play a critical role in defending the host against foreign organisms and regulating behavior of other cells. circulate as nonadherent cells blood migrate adherent through tissues. Adhesion molecules mediate not only cell adhesion, but also migration, phagocytosis, many adhesion-dependent functions. Monocyte chemoattractant protein-1 (MCP-1) is thought to be responsible for monocyte recruitment acute inflammatory conditions may an important mediator chronic inflammation. In this...
Both lesions of endodontic origin and periodontal diseases involve the host response to bacteria formation osteolytic lesions. Important for both is upregulation inflammatory cytokines that initiate sustain response. Also important are chemokines induce recruitment leukocyte subsets bone-resorptive factors largely produced by recruited cells. However, there differences also. Lesions pose a particular challenge since persist in protected reservoir not readily accessible immune defenses. Thus,...
Periodontal disease is characterized by both inflammation and bone loss. Advances in research these areas have led to a new appreciation of not only each field but also the intimate relationship between This has resulted science called osteoimmunology provides context for better understanding pathogenesis periodontal disease. In this review, we discuss several aspects immuno-inflammatory host response that ultimately results loss alveolar bone. A proposal made stimulates osteoclastogenesis...
Periodontal disease is more common in individuals with rheumatoid arthritis (RA) who have detectable anti-citrullinated protein antibodies (ACPAs), implicating oral mucosal inflammation RA pathogenesis. Here, we performed paired analysis of human and bacterial transcriptomics longitudinal blood samples from patients. We found that patients periodontal experienced repeated bacteremias associated transcriptional signatures ISG15 + HLADR hi CD48 high S100A2 pos monocytes, recently identified...
Type 1 diabetes in humans has as one of its complications inadequate bone formation, resulting osteopenia and delayed fracture healing. To investigate the mechanisms by which affects experiments were performed a marrow ablation model. Mice made diabetic multiple low-dose streptozotocin treatment, controls treated with vehicle alone. Killing occurred 0, 2, 4, 6, 10, 16 d following ablation. Histologic analysis demonstrated that amount immature mesenchymal tissue was equivalent both...
Using a ligature-induced model in type-2 Zucker diabetic fatty (ZDF) rat and normoglycemic littermates, we investigated whether diabetes primarily affects periodontitis by enhancing bone loss or limiting osseous repair. Diabetes increased the intensity duration of inflammatory infiltrate (P < 0.05). The formation osteoclasts percent eroded after 7 days ligature placement was similar, while four removal ligatures, type 2 group had significantly higher osteoclast numbers activity amount new...
A protein chemotactic for peripheral blood monocytes (SMC-CF) of potential importance in their recruitment to the arterial intima atherogenesis was purified from serum-free medium conditioned by cultured baboon aortic medial smooth muscle cells. The purification SMC-CF monitored a filter assay using human mononuclear cells and achieved batch separation on cation-exchange gel followed permeation chromatography, ion-exchange high-performance liquid chromatography (HPLC), reversed-phase HPLC....
The effect of type 1 diabetes on bone healing and formation in standardized craniotomy defects created BALB/cByJ mice was determined. hypothesis that advanced glycation end products (AGEs) contribute to diminished evaluated by assessing for the presence receptor (RAGE) immunohistochemistry diabetic animals. local application a known RAGE protein ligand, Nε-(carboxymethyl)lysine (CML)−mouse serum albumin (MSA), defect normal animals then assessed compared effects control MSA. Finally,...
Macrophages are thought to play an important role in the pathologic changes associated with idiopathic pulmonary fibrosis (IPF). The mechanisms for increased monocyte/macrophage recruitment IPF unknown. Monocyte chemoattractant protein 1 (MCP-1) is predominant monocyte secreted by a variety of different cell types culture. We examined expression MCP-1 mRNA and its product vivo non-IPF lung specimens situ hybridization immunocytochemistry. expressing were identified immunostaining specific...
Abstract Histological and molecular analysis of fracture healing in normal diabetic animals showed significantly enhanced removal cartilage animals. Increased turnover was associated with elevated osteoclast numbers, a higher expression genes that promote osteoclastogenesis, diminished primary bone formation. Introduction: Diminished formation, an increased incidence nonunions, delayed have been observed animal models patients diabetes. Fracture is characterized by the formation stabilizing...