A5101584372- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Gut microbiota and health
- Neurogenesis and neuroplasticity mechanisms
- Sleep and Wakefulness Research
- Zebrafish Biomedical Research Applications
- Cancer-related molecular mechanisms research
- Tryptophan and brain disorders
- Berberine and alkaloids research
- Immune Response and Inflammation
- PI3K/AKT/mTOR signaling in cancer
- Fungal Biology and Applications
- Ginseng Biological Effects and Applications
- Cannabis and Cannabinoid Research
- Nuclear Receptors and Signaling
- Melanoma and MAPK Pathways
- Alkaloids: synthesis and pharmacology
- Dietary Effects on Health
Bengbu Medical College
2023
Southern Medical University
2017-2021
Morphine is one of the most severely abused drugs in world. Previous research on morphine addiction has focused central nervous system (CNS). Studies have shown that a two-way regulation brain and gut microbiota (GM), suggesting link between GM CNS disease. However, functional mechanism underlying relationship intestinal flora dependence unclear. In this study, effect sinomenine was evaluated based microbiota-gut-brain axis (MGBA). The results show plays an important role dependence....
Drug abuse is a public health and social problem. A number of studies have reported that drug addiction associated with microRNAs (miRNAs). By comparing the expression miRNAs in serum exosomes methamphetamine‑dependent ketamine‑dependent rats, aim present study was to provide insights into miRNA‑mediated associations between two groups. Published results on conditioned place preference (CPP) rats by methamphetamine ketamine were replicated. The determined gene‑chip sequencing. potential...
Objective. To compare the expressions of miRNAs (microRNAs) in serum exosomes and hippocampus to provide insights into miRNA‐mediated relationship between peripheral central nervous systems presence methamphetamine. Methods. Published results on conditioned place preference (CPP) rats by methamphetamine were replicated. The determined gene‐chip sequencing. We then predicted potential target genes selected, differentially expressed (DE) carried out functional analysis these genes. also...
Sinomenine is a nonaddictive alkaloid used to prevent morphine dependence, even thoughits mechanism isnot fully understood. Astrocytes aggravate the pathological process in their neighboring cellsthrough exosomes central nervous system diseases. However, effect of sinomenine on astrocyte-derived for amelioration dependence has not been reported yet. In this study, we found that prevented morphine-induced conditionedplace preference mice. reduced levels cAMP and intracellular Ca2+...
Morphine abuse is a global public health problem. Increasing evidence has shown that gut microbiota dysbiosis plays an important role in several central nervous system diseases. However, whether there association between and morphine dependence remains unclear. In this study, the effects of isorhynchophylline on were evaluated based microbiota-gut-brain axis (MGBA). The results showed could reverse changes alpha beta diversity, composition, richness intestinal flora occurring...
<b><i>Introduction:</i></b> Rhynchophylline, as a traditional Chinese medicine, was used for the treatment of drug addiction. Objective: To investigate miRNAs expression profile in rat hearts methamphetamine dependence and intervention mechanisms rhynchophylline. <b><i>Materials Methods:</i></b> This study detected methamphetamine-induced by microarray verified miR-133a-5P Rho-associated, coiled-coil containing protein kinase 2 (ROCK2) protein....
Methamphetamine (Meth) is a highly addictive substance and the largest drug threat across globe. There evidence to indicate that Meth use has serious damage on central nervous system (CNS) heart in several animal human studies. However, connection process of addiction between these two systems not been determined. Emerging data suggest extracellular vesicles (EVs) carrying behavior-altering microRNA (miRNAs) play crucial role cell communication CNS peripheral system. Rhynchophylline (Rhy),...