A5100336750- Signaling Pathways in Disease
- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- Cardiac Fibrosis and Remodeling
- Cardiac Ischemia and Reperfusion
- Berberine and alkaloids research
- Cell death mechanisms and regulation
- PARP inhibition in cancer therapy
- Bone Metabolism and Diseases
- Medicinal Plant Pharmacodynamics Research
- Calpain Protease Function and Regulation
- MicroRNA in disease regulation
- Cardiac electrophysiology and arrhythmias
- Autophagy in Disease and Therapy
- Neurobiology and Insect Physiology Research
- Bioactive Natural Diterpenoids Research
- Nerve injury and regeneration
- Estrogen and related hormone effects
- Bone health and osteoporosis research
Jiamusi University
2025
Qiqihar Medical University
2021-2022
Southern Medical University
2019
First Affiliated Hospital of Bengbu Medical College
2016
Jiangsu University
2016
Affiliated Hospital of Jiangsu University
2016
Nantong University
2013
Nankai University
2011
Glucocorticoids are widely used in clinical practice; however, they can cause side effects, such as osteoporosis. Acteoside (ACT) from Cistanche has been to combat a variety of diseases. The study was conducted evaluate the efficacy ACT glucocorticoid-induced osteoporosis (GIOP) and its potential mechanism.Dexamethasone (Dex) injected intramuscularly induce rat model, given orally. supplemented vivo Dex-stimulated osteoblastic MC3T3-E1 cells. RT-qPCR performed assess mRNA levels bone...
Sijunzi Decoction (SD) is a traditional Chinese medicine which composed of Ginseng, Atractylodes, Poria and Licorice. It one the commonly used medicines that showed anti-gastric cancer activity in clinical studies. Previous evidence demonstrated SD parties (Ginseng, Poria, Licorice) can inhibit proliferation induced apoptosis for gastric cell. In order to further investigate anticancer effect cancer, we observed effects different concentrations on Side Population Cells (SP) human SGC-7901.
<b><i>Introduction:</i></b> Rhynchophylline, as a traditional Chinese medicine, was used for the treatment of drug addiction. Objective: To investigate miRNAs expression profile in rat hearts methamphetamine dependence and intervention mechanisms rhynchophylline. <b><i>Materials Methods:</i></b> This study detected methamphetamine-induced by microarray verified miR-133a-5P Rho-associated, coiled-coil containing protein kinase 2 (ROCK2) protein....
Effective drug intervention is the most important method to improve prognosis, quality of life, and prolong life patients with heart failure. This study aimed explore protective effect astragaloside IV on myocardial cell injury induced by oxidized low-density lipoprotein (OxLDL) its regulatory mechanism increase brain natriuretic peptide (BNP) caused injury. The model injury, protection, histone deacetylase (HDAC) inhibition in HL-1 mice was established OxLDL treatment, intervention, UF010...
The tubulin beta III (TUBB3) gene encodes a class member of the protein family that is primarily expressed in neurons and considered to play critical role proper axon guidance maintenance. This generally used as specific marker central nervous system. We obtained full length cDNA sequence TUBB3 by using RACE method based on EST fragment from brain spinal cord library Gekko japonicus. further investigated multi-tissue expression pattern RT-PCR identified one transcript about 1.8 kb system...
目的研究人参皂苷Rh2（Rh2）对人白血病细胞KG1α增殖的抑制作用，并从自噬凋亡角度来探讨其机制。 方法采用CCK-8法检测Rh2对KG1α细胞增殖的抑制作用；流式细胞术（FCM）检测细胞凋亡；Hoechest染色观察细胞核染色质的形态；吖啶橙染色观察Rh2对细胞自噬的影响；Western blotting和RT-PCR检测Rh2对白血病细胞自噬重要蛋白和基因表达的影响；运用自噬抑制剂（3-MA）研究自噬对细胞增殖和凋亡的影响。 结果CCK-8显示Rh2在低浓度时能有效抑制KG1α细胞增殖，且其抑制作用具有浓度和时间依赖性；FCM检测和Hoechest染色结果显示Rh2能增加细胞的凋亡，使染色质呈凋亡形态改变；吖啶橙染色发现Rh2组细胞绿色荧光增强，细胞出现大量的酸性自噬小泡；Western blotting和RT-PCR结果发现Rh2上调Beclin-1、LC3A、LC3B、激活型Caspase-3表达和增加Bax/Bcl-2值，并激活MAPK、ATK、ERK信号通路；细胞自噬剂（3-MA）会削弱Rh2对KG1α细胞的增殖抑制和促凋亡作用。 ...