A5100610612- Intraocular Surgery and Lenses
- Ophthalmology and Visual Impairment Studies
- Dementia and Cognitive Impairment Research
- Corneal surgery and disorders
- Connexins and lens biology
- Oral Health Pathology and Treatment
- Alzheimer's disease research and treatments
- MicroRNA in disease regulation
- Photodynamic Therapy Research Studies
- Autophagy in Disease and Therapy
- Telomeres, Telomerase, and Senescence
- Porphyrin and Phthalocyanine Chemistry
- Epigenetics and DNA Methylation
- Nanoplatforms for cancer theranostics
- Phytochemical Studies and Bioactivities
- Marine Sponges and Natural Products
- Genomics and Chromatin Dynamics
- Cancer-related gene regulation
- Bioactive Natural Diterpenoids Research
- Endoplasmic Reticulum Stress and Disease
- RNA Interference and Gene Delivery
- Phytochemistry and Bioactive Compounds
- Natural product bioactivities and synthesis
- Cell death mechanisms and regulation
- Cancer-related Molecular Pathways
Florey Institute of Neuroscience and Mental Health
2023-2025
The University of Melbourne
2023-2025
First Affiliated Hospital of Zhengzhou University
2017-2025
Qiqihar Medical University
2014-2025
Anhui Medical University
2025
He Eye Hospital
2019-2025
Peking University
2008-2024
Lishui City People's Hospital
2024
Xiangya Hospital Central South University
2013-2023
Central South University
2012-2023
Metformin, a first-line drug for type 2 diabetes, could induce apoptosis in cancer cells. However, the concentration of glucose affects effect metformin, especially low culture medium can enhance cytotoxicity metformin on Since mitochondria and endoplasmic reticulum is vital maintaining cell homeostasis, we speculate that metformin-induced may be associated with reticulum. ASK1, as signaling regulating kinase 1, mitochondrial damage. This study was designed to investigate functional...
Cerebral amyloid angiopathy (CAA) is a cerebrovascular condition, the severity of which can only be determined post mortem. Here, we developed machine learning models, Florey CAA Score (FCAAS), to predict (none/mild/moderate/severe). Building on an auto-score-ordinal algorithm, FCAAS models were and validated using data collected by three cohort studies aging dementia. The digitized as web-based tool. A pilot trial was conducted this FCAAS-4 achieved mean area under receiver operating...
Jumonji domain‐containing protein 6 (JMJD6), a histone arginine demethylase, plays multifaceted and significant role in embryonic development cancer progression. However, the function of JMJD6 its precise mechanism regulating hepatocellular carcinoma (HCC) remain unknown. Here, we show that aberrant overexpression is associated with poor prognosis aggressive characteristics HCC. In hepatoma cell lines, demonstrated knockdown inhibited migration proliferation. displays opposite effects....
Abstract Background The associations between mood disorders (anxiety and depression) mild cognitive impairment (MCI) or Alzheimer’s dementia (AD) remain unclear. Methods Data from the Australian Imaging, Biomarker & Lifestyle (AIBL) study were subjected to logistic regression determine both cross-sectional longitudinal anxiety/depression MCI/AD. Effect modification by selected covariates was analysed using likelihood ratio test. Results Cross-sectional analysis performed explore...
Bcl-2, which belongs to the Bcl-2 family, is frequently overexpressed in various types of cancer cells and contributes drug resistance. However, function cisplatin resistance human ovarian not fully understood. In this study, we found that pharmacological inhibitor ABT737 or genetic knockdown increased cytotoxicity cisplatin-resistant cells. Additionally, treatment with siRNA cisplatin-induced free Ca2+ levels cytosol mitochondria, endoplasmic reticulum (ER)-associated mitochondria-mediated...
Summary The nucleolus is a key organelle that responsible for the synthesis of rRNA and assembly ribosomal subunits, which also center metabolic control because critical role ribosomes in protein synthesis. Perturbations biogenesis are closely related to cell senescence tumor progression; however, underlying molecular mechanisms not well understood. Here, we report cellular senescence‐inhibited gene ( CSIG ) knockdown up‐regulated NOLC 1 by stabilizing 5′ UTR mRNA , elevated induced...
Resistance to temozolomide (TMZ) remains is an important cause of treatment failure in patients with glioblastoma multiforme (GBM). ADAR1, as a member the ADAR family, plays role cancer progression and chemotherapy resistance. However, mechanism by which ADAR1 regulates GBM TMZ resistance still unclear. We first constructed stable transfected strains was knocked down overexpressed investigate effect on first-line glioma drug TMZ. Subsequently, we validated that induces autophagy activation...
Cerebral amyloid angiopathy (CAA) increases the risk of amyloid-related imaging abnormalities in Alzheimer's disease (AD) patients receiving anti-amyloid-beta therapies, emphasizing need to identify its factors. Data were collected from three cohort studies, and a machine learning model was developed predict CAA occurrence using selected The AD neuropathologic changes (ADNC)-CAA association significantly positive cross-sectional analysis. When stratified by factors, this generally stronger...
Adaptation of cyclic brush polymer for drug delivery applications remains largely unexplored. Herein, copolymer poly(2-hydroxyethyl methacrylate-g-poly(N-isopropylacrylamide-st-N-hydroxyethylacrylamide)) (cb-P(HEMA-g-P(NIPAAm-st-HEAAm))), comprising a core PHEMA and thermosensitive brushes statistical P(NIPAAm-st-HEAAm), is designed synthesized successfully via graft-from approach using atom transfer free radical polymerization from multimacroinitiator. The composition the optimized to endow...
Aminolevulinic acid (ALA), ALA methylester (ALA-Me) and hexylester (ALA-Hex) were topically applied for 5 20 hr, respectively, on normal skin of mice. The distribution protoporphyrin IX (PpIX) induced in 7 different tissues by these drugs was determined either spectrofluorometric measurements with an optical fibre probe or chemical extraction PpIX from the tissues. results 2 types compared. Both methods showed that esters similar amounts at spot where they produced much less remote spots...
Abstract. Purpose: To determine whether bilateral implantation of an aspheric apodized diffractive multifocal intraocular lens (IOL) with +3.00 diopters (D) results in optical adverse effects compared monofocal IOL. Methods: In a prospective, randomized study 204 eyes (102 patients) AcrySof ReSTOR SN6AD1 IOL or IQ SN60WF IOL, binocular uncorrected (UDVA) and corrected distance visual acuities (CDVA), (UIVA) distance‐corrected intermediate (DCIVA), (UNVA) near (DCNVA), defocus curve,...
The development of temozolomide (TMZ) resistance in glioma leads to poor patient prognosis. Sorafenib, a novel diaryl urea compound and multikinase inhibitor, has the ability effectively cross blood-brain barrier. However, effect sorafenib on cells molecular mechanism underlying enhance antitumor effects TMZ remain elusive. Here, we found that could cytotoxic
Using a suppressive subtractive hybridization system, we identified CSIG (cellular senescence-inhibited gene protein; RSL1D1) that was abundant in young human diploid fibroblast cells but declined upon replicative senescence. Overexpression or knockdown of did not influence p21(Cip1) and p16(INK4a) expressions. Instead, negatively regulated PTEN p27(Kip1) expressions, turn promoting cell proliferation. In PTEN-silenced HEK 293 PTEN-deficient glioblastoma U87MG cells, the effect on expression...
MicroRNA-24 (miR-24) serves an important role in cell proliferation, migration and inflammation various types of disease. In the present study, biological function molecular mechanism miR‑24 was investigated association with progression age‑associated cataracts. To best our knowledge study is first to report that expression significantly increased human anterior lens capsules affected by cataracts as well epithelial cells (LECs) exposed oxidative stress. Overexpression induced p53 verified a...
A 79-year-old white man had cataract surgery in the right eye with implantation of an Acqua® intraocular lens (IOL) (Mediphacos). Trypan blue 0.1% was used during to stain anterior capsule and enhance contrast capsulorhexis. Seven days after surgery, patient presented “dark double” vision (monocular diplopia). The IOL decentered superiorly appeared dark blue. explanted 2 months sent for gross microscopic analyses a dry state hydration. same were performed on unused lenses design that been...