A5023538886- Oral Health Pathology and Treatment
- Oral and Maxillofacial Pathology
- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Cancer and Skin Lesions
- Oral and gingival health research
- Cancer Diagnosis and Treatment
- Corrosion Behavior and Inhibition
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Hedgehog Signaling Pathway Studies
- RNA modifications and cancer
- Hydrogen embrittlement and corrosion behaviors in metals
- Genetic factors in colorectal cancer
- Health and Wellbeing Research
- Concrete Corrosion and Durability
- Periodontal Regeneration and Treatments
- Antifungal resistance and susceptibility
- Cholangiocarcinoma and Gallbladder Cancer Studies
- NF-κB Signaling Pathways
- Salivary Gland Disorders and Functions
- Oral microbiology and periodontitis research
- Autoimmune and Inflammatory Disorders
- Immunodeficiency and Autoimmune Disorders
Shanghai Ninth People's Hospital
2015-2024
Shanghai Jiao Tong University
2015-2024
West China Medical Center of Sichuan University
2021-2024
Sichuan University
2023
Chinese Academy of Sciences
2019-2021
National Clinical Research Center for Digestive Diseases
2019-2021
University of Science and Technology of China
2019-2021
Stomatology Hospital
2021
National Clinical Research
2019-2020
Zero to Three
2014
Background Oral leukoplakia (OL) is the best-known potentially malignant disorder. The objective of current study was to evaluate clinicopathological factors predictive outcome in a large cohort patients with OL, and report our experience early detection events. Methods A total 320 biopsy-proven OL were retrospectively reviewed from institution who had mean follow-up 5.1 years. Data on patient lesion at initial diagnosis underwent sequential biopsies reviewed. Multiple indicates > = 3 times...
Oral squamous cell carcinoma (OSCC), which is typically preceded by oral leukoplakia (OL), a common malignancy with poor prognosis. However, the signaling molecules governing this progression remain to be defined. Based on microarray analysis of genes expressed in OL and OSCC samples, we discovered that long non-coding RNA IFITM4P was highly OSCC, ectopic expression or knockdown resulted increased decreased proliferation vitro xenografted tumors, respectively. Mechanistically, cytoplasm...
Molecular markers for predicting oral cancer development in premalignant leukoplakia (OL) are urgently needed. The objective of this study was to examine the expression patterns stem cell ALDH1 and CD133 samples from patients with OL, determine their prognostic values subsequent cancer. Immunohistochemistry performed a cohort 141 biopsy-proven OL who received mean follow-up 5.5 years. Patient clinicopathologic data were analyzed. Expression observed 54 (38.3%) 32 (22.7%) respectively....
Background An epidemiological study on the oral mucosal lesions ( OML s) in general population from China was scarce. The objective of this to investigate prevalence and distribution s Shanghai, evaluate their association with demographic factors smoking/drinking habits based a large scaled wide spectrum. Methods In population‐based cross‐sectional study, 11054 community‐dwelling individuals (M/F: 5140/5914; age range, 1–96 years) were randomly selected examined according WHO criteria....
Liu W, Bao Z-X, Shi L-J, Tang G-Y & Zhou Z-T (2011) Histopathology ;59, 733–740 Malignant transformation of oral epithelial dysplasia: clinicopathological risk factors and outcome analysis in a retrospective cohort 138 cases Aims: To explore the usefulness new binary system grading dysplasia proposed by World Health Organization to identify significant for malignant long-term follow-up patients with dysplasia. Methods results: A total histologically confirmed between 1978 2008 were reviewed...
Oral leukoplakia (OLK) is a potentially malignant disorder of the oral cavity. However, underlying mechanism OLK still unclear. In this study, we explore possible miRNAs involved in OLK.Using miRNA microarrays, profiled expression and malignantly transformed (mtOLK) tissue samples. The upregulation miR-31*, miR-142-5p, miR-33a, miR-1259, miR-146b-5p, miR-886-3p, miR-886-5p, miR-519d, miR-301a along with downregulation miR-572, miR-611, miR-602, miR-675, miR-585, miR-623, miR-637, miR-1184...
Oral squamous cell carcinoma (OSCC) is a common malignancy with poor prognosis. MicroRNAs (miRNAs) play an important role in cancer, but their OSCC not clarified.We performed miRNA microarray, quantitative reverse transcription polymerase chain reaction (qRT-PCR), and fluorescence situ hybridization (FISH) to examine expression paired adjacent cancer-free mucosal (ACF) tissues.Thirteen miRNAs, including miRNA-155, were upregulated (>2-fold) against ACF. MiRNA-155 was confirmed have...
Scientometric analysis is a useful tool that utilizes bibliometric data to measure scientific output of disease or region in particular field. In this report, we comprehensively provide characteristics all the papers on betel quid (BQ)-related cancer and precancerous lesions. There are 1403 BQ-related lesions published until 2022 Scopus database. China (mainland Taiwan region), India, United States, Kingdom contribute 1214 (86.5%) 34,120 (91.9%) citations papers. The number (457), (14,573),...
J Oral Pathol Med (2013) 42 : 148–153 Background: erythroplakia (OE) is a notoriously aggressive oral pre‐malignant lesion with high tendency to cancer development, but its biological behavior largely unknown. The objective of this study was determine the expression stem cell markers ALDH1 and Bmi1 in OE their correlation malignant transformation OE. Methods: In retrospective case–control study, patterns were determined using immunohistochemistry samples from 34 patients OE, including...
BACKGROUND: Oral squamous cell carcinoma (OSCC) is the most common malignant neoplasm of mouth. Some studies have found that multiple microRNAs (miRs) participate in OSCC physiological and pathological processes. METHODS: We explored mechanism action miR-134 involving PI3K-Akt signaling pathway. Different bioinformatics methods were used to analyze potential genes their related miRs OSCC. Tumor stem cells separated from OSCCs through magnetic sorting. Regulatory pattern between LAMC2 was...
Oral lichen planus (OLP), a chronic inflammatory disease of unknown etiology, is considered potentially malignant oral disorder. The aim the present study was to analyze candidate microRNAs (miRNAs) and genes from patients with OLP healthy controls (HCs).Biopsy specimens mucosa were collected (n = 9) HCs 4). Differentially expressed miRNAs differentially screened by using next-generation sequencing DESeq edgeR software algorithms.A total 94 599 detected in OLP. Potential regulatory obtained...
J Oral Pathol Med (2012) 41 : 131–135 Background: verrucous hyperplasia (VH) and carcinoma (VC) are two clinicopathologically distinctive oral lesions. The objective of this study was to investigate the clinicopathological features lesions estimate their relationship from China. Methods: Retrospective review series patients with histologically confirmed VH ( n = 121) VC 56) between 1996 2009 in our hospital were conducted. Results: average age 58.5 years (ratio male:female 1.37) tongue being...
Abstract Background: Bibliometric analysis highlights the key topics and studies which have shaped understanding management of a disease interest. Here top-cited articles on oral leukoplakia (OL) were characterized, research patterns trends analyzed. Methods: A comprehensive search was performed identified in Scopus database up to 22 February 2019 for 100 most-cited OL. Results: The number citations selected varied from 116 1418, with mean 226.7 per article. Both Journal Oral Pathology...