A5100664114- IL-33, ST2, and ILC Pathways
- Wound Healing and Treatments
- Hepatitis B Virus Studies
- Antimicrobial Peptides and Activities
- Immune Cell Function and Interaction
- Chromium effects and bioremediation
- Oral and Maxillofacial Pathology
- Andrographolide Research and Applications
- Aquaculture disease management and microbiota
- Invertebrate Immune Response Mechanisms
- Hepatitis C virus research
- Traditional Chinese Medicine Analysis
- Pressure Ulcer Prevention and Management
- Dental Radiography and Imaging
- Vector-borne infectious diseases
- Liver Disease Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Dermatology and Skin Diseases
- Immune Response and Inflammation
- Winter Sports Injuries and Performance
- RNA modifications and cancer
- Aquaculture Nutrition and Growth
- Oral Health Pathology and Treatment
- Cancer Research and Treatments
- Ginseng Biological Effects and Applications
Fudan University Shanghai Cancer Center
2022-2025
Shanghai Medical College of Fudan University
2025
Shanghai Xuhui Central Hospital
2020-2024
Zhanjiang Experimental Station
2024
Hebei University
2009-2023
Xiamen University
2022
East China Normal University
2013-2022
Dalian Ocean University
2020
Ministry of Agriculture and Rural Affairs
2020
Shanxi Agricultural University
2003-2019
Dysregulated inflammatory responses are known to impair wound healing in diabetes, but the underlying mechanisms poorly understood. Here we show that antimicrobial protein REG3A controls TLR3-mediated inflammation after skin injury. This control is mediated by REG3A-induced SHP-1 protein, and acts selectively on TLR3-activated JNK2. In diabetic mouse skin, hyperglycaemia inhibits expression of IL-17-induced IL-33 via glucose glycation. The decrease cutaneous reduces epidermal keratinocytes....
Metabolic reprogramming is often observed in carcinogenesis, but little known about the aberrant metabolic genes involved tumorigenicity and maintenance of stemness cancer cells. Sixty-seven oncogenic metabolism-related liver by vivo CRISPR/Cas9 screening are identified. Among them, acetyl-CoA carboxylase 1 (ACC1), aldolase fructose-bisphosphate A (ALDOA), fatty acid binding protein 5 (FABP5), hexokinase 2 (HK2) strongly associated with stem cell properties. HK2 further facilitates...
Abstract Aberrant RNA splicing in keratinocytes drives inflammatory skin disorders. In the present study, we found that helicase DDX5 was downregulated from lesions patients with atopic dermatitis and psoriasis, mice keratinocyte-specific deletion of Ddx5 ( ∆KC ) were more susceptible to cutaneous inflammation. Inhibition expression induced by cytokine interleukin (IL)-17D through activation CD93–p38 MAPK–AKT–SMAD2/3 signaling pathway led pre-messenger events favored production...
Staphylococcus epidermidis (S.epidermidis) plays important protective roles by directly producing or stimulating hosts to produce antimicrobial peptides (AMPs) against pathogenic infections. Although several AMPs from S.epidermidis have been identified, molecules that stimulate remain largly unknown. Here we demonstrate a new lipopeptide (named LP01) purified culture media has unique structure with heneicosanoic acid (21 carbons) binding lysine11 of peptide chain. In vitro LP01 increased the...
Interleukin-33 (IL-33) is associated with multiple diseases, including asthma, rheumatoid arthritis, tissue injuries and infections. Although IL-33 has been indicated to be involved in Staphylococcus aureus (S. aureus) wound infection, little known about how regulated as a mechanism increase host defense against skin bacterial To explore the underlying intricate we first evaluated expression of from S. aureus-infected human patients. Compared normal controls, was abundantly increased We next...
Abstract Aldolase A (ALDOA), a crucial glycolytic enzyme, is often aberrantly expressed in various types of cancer. Although ALDOA has been reported to play additional roles beyond its conventional enzymatic role, nonmetabolic function and underlying mechanism cancer progression remain elusive. Here, it shown that promotes liver growth metastasis by accelerating mRNA translation independent catalytic activity. Mechanistically, interacted with insulin‐ like factor 2 mRNA‐binding protein 1...
Increasing evidence indicates that andrographolide (ADG) exhibits anti-cancer activity against various cancer cell lines. However, its high hydrophobicity and poor bioavailability restrict clinical application as a chemopreventative agent. Previously, we have shown ADG-loaded solid lipid nanoparticles (SLNs) significantly enhanced the anti-hyperlipidemic of ADG.We aimed to investigate whether ADG-SLN efficacy ADG in human immortalized oral epithelial (HIOEC), precancerous leukoplakia...
Abstract Emerging evidence has demonstrated that long noncoding RNAs (lncRNAs) are promising targets or agents for the treatment of human cancers. Most liver-specific lncRNAs exhibit loss expression and act as tumor suppressors in liver cancer. Modulating these is a potential approach lncRNA-based gene therapy hepatocellular carcinoma (HCC). Here, we report lncRNA FAM99B significantly decreased HCC tissues suppresses cell proliferation metastasis both vitro vivo. promotes nuclear export...
The uniqueness of soft materials such as hydrogels allows for great potential new robots and actuators. Conventional underwater are generally crafted rigid structures with water-mismatched acoustic impedance, severely limiting their operating capabilities. Therefore, flexible acoustically transparent show prospects applications in marine exploration, biomedical engineering, etc. Inspired by the high water content jellyfish, we report a hydraulically actuated bioinspired hydrogel jellyfish....
Although we have previously demonstrated that phospholipid complex loaded nanoparticles (PLC-NPs) encapsulating salvianolic acid B (SAB) can enhance anticancer activity in head and neck cancer precancerous cells vitro, the chemopreventive efficacy of SAB-PLC-NPs (nano-SAB) vivo remains unclear. Here, aimed to investigate nano-SAB against experimental oral carcinogenesis.Oral tongue carcinogenesis was induced C57BL/6 mice through administration 4-nitroquinoline-N-oxide (4NQO, 100 µg/mL)...
To determine whether -238G/A and -857C/T polymorphisms of tumor necrosis factor-alpha (TNF-alpha), gene promoter hepatitis B (HB) viral genotypes were associated with outcomes HBV infection.A total 244 self-limited infected subjects, 208 asymptomatic carriers, 443 chronic HB patients recruited to conduct a case-control study. TNF-alpha-238G/A examined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), nested PCR.The positive rate DNA in carrier group was 46.6%...
Natural killer (NK)-lysin, a broad-spectrum antimicrobial peptide, has antitumor and antibactericidal activities against both gram-positive gram-negative bacteria. In this study the recombinant porcine NK-lysin was expressed purified in Pichia pastoris system, then 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide used to assess its anticancer activity vitro. The results showed that possesses potent human hepatocellular carcinoma cell line SMMC-7721 time- dose-dependent manner,...
Experimental design and additivesThe experiment applied the of two factors (chromium×L-carnitine), 3×4 levels with repeats.Yeast Chromium (the actually content Cr 1 g/kg, Beijing Alltech biology technique company) was supplied at level 0, 400, 600 µg/kg.L-carnitine (Carniking Hongkong Company), which is composed L-carnitine (50%), silicon dioxide (34%) water (16%), no Dand meso-carnitine, provided by China Agriculture Academy, added 30, 50, 100 mg/kg.