A5016613550- Fungal Biology and Applications
- Entomopathogenic Microorganisms in Pest Control
- Mycorrhizal Fungi and Plant Interactions
- Gastrointestinal Bleeding Diagnosis and Treatment
- Environmental Toxicology and Ecotoxicology
- Aquaculture Nutrition and Growth
- Insect symbiosis and bacterial influences
- Pharmaceutical and Antibiotic Environmental Impacts
- Bioinformatics and Genomic Networks
- Microbial Metabolic Engineering and Bioproduction
- Gastrointestinal disorders and treatments
- Selenium in Biological Systems
- Insect Resistance and Genetics
- Insect Utilization and Effects
- Environmental DNA in Biodiversity Studies
- Fungal and yeast genetics research
- Invertebrate Immune Response Mechanisms
- Circular RNAs in diseases
- Advanced Data Compression Techniques
- Neuroscience, Education and Cognitive Function
- Metallurgy and Material Forming
- Civil and Geotechnical Engineering Research
- Sentiment Analysis and Opinion Mining
- Grouting, Rheology, and Soil Mechanics
- Health Education and Validation
Liaoning Ocean and Fisheries Research Institute
2023-2024
Hunan Normal University
2022
Hunan Provincial People's Hospital
2022
Fudan University
2017-2020
Center for Excellence in Molecular Plant Sciences
2013-2020
Chinese Academy of Sciences
2011-2020
Shanghai Institutes for Biological Sciences
2012-2016
Second Military Medical University
2014
Changhai Hospital
2014
Anhui Medical University
2013
Metarhizium spp. are being used as environmentally friendly alternatives to chemical insecticides, model systems for studying insect-fungus interactions, and a resource of genes biotechnology. We present comparative analysis the genome sequences broad-spectrum insect pathogen anisopliae acridid-specific M. acridum. Whole-genome analyses indicate that structures these two species highly syntenic suggest genus evolved from plant endophytes or pathogens. Both acridum have strikingly larger...
The ascomycete fungus Beauveria bassiana is a pathogen of hundreds insect species and commercially produced as an environmentally friendly mycoinsecticide. We sequenced the genome B. phylogenomic analysis confirmed that entomopathogenicity polyphyletic, but also revealed convergent evolution to pathogenicity. found many species-specific virulence genes gene family expansions contractions correlate with host ranges pathogenic strategies. These include having more bacterial-like toxins...
Abstract Background Species in the ascomycete fungal genus Cordyceps have been proposed to be teleomorphs of Metarhizium species. The latter widely used as insect biocontrol agents. species are highly prized for use traditional Chinese medicines, but genes responsible biosynthesis bioactive components, pathogenicity and control sexuality fruiting not determined. Results Here, we report genome sequence type militaris . Phylogenomic analysis suggests that different / genera evolved into...
Significance Fossil records have provided compelling evidence for evolution, but lack of existing transitional species has hindered our understanding speciation at the molecular level. Genomic analyses seven Metarhizium revealed a directional continuum from specialists with narrow host ranges to and then generalists that paralleled insect evolution. This diversification was coupled complex interplay between an array genomic features worked together drive fungal accelerating rate roadmap...
Fungal pathogens of plants and animals have multifarious effects; they cause devastating damages to agricultures, lead life-threatening diseases in humans, or induce beneficial effects by reducing insect pest populations. Many virulence factors been determined different fungal pathogens; however, the molecular determinants contributing host selection adaptation are largely unknown. In this study, we sequenced genomes seven ascomycete performed genome-wide analyses 33 species filamentous...
Objective: To assess the feasibility and safety of magnetic-controlled capsule endoscopy (MCE) system for examination human stomach.Methods: This pilot study enrolled 34 healthy volunteers.All subjects swallowed MCE gas-producing powder gastric distention.An external robot was used to generate magnetic field manipulate inside stomach.The primary measurements included safety, preparation, maneuverability visualization mucosa.Results: Gastric preparation well accepted by there were no adverse...
Background Lepidoptera insects have a novel development process comprising several metamorphic stages during their life cycle compared with vertebrate animals. Unlike most that live on nectar the adult stage, Bombyx mori silkworm adults do not eat anything and die after egg-laying. In addition, midguts of produce antimicrobial proteins wandering stage when larval tissues undergo numerous changes. The exact mechanisms responsible for these phenomena remain unclear. Principal Findings We used...
Filamentous fungi including mushrooms frequently and spontaneously degenerate during subsequent culture maintenance on artificial media, which shows the loss or reduction abilities of asexual sporulation, sexuality, fruiting, production secondary metabolites, thus leading to economic losses mass production. To better understand underlying mechanisms fungal degeneration, model fungus Aspergillus nidulans was employed in this study for comprehensive analyses. First, linkage oxidative stress...
Ascomycete Cordyceps species have been using as valued traditional Chinese medicines. Particularly, the fruiting bodies of cicadae (syn. Isaria cicadae) long utilized for treatment chronic kidney disease. However, genetics and bioactive chemicals in this fungus largely unexplored. In study, we performed comprehensive omics analyses C. cicadae, found that, contrast to other fungi, produces asexual with production conidial spores instead meiotic ascospores. Genome sequencing comparative...
The effects of a selenium-supplemented diet on the antioxidant enzyme activity superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) in muscles shrimp, Neocaridina heteropoda, were investigated. Purified diets with six levels (0, 0.15, 0.30, 0.45, 0.60, 0.75 μg/g) supplemental Se fed to N. heteropoda for three months. CAT GPX was determined after one month SOD every month. enzymes dose dependant; all significantly higher shrimp Se-sup- plemented than those...
Abstract Background Rapid progress in high-throughput biotechnologies (e.g. microarrays) and exponential accumulation of gene functional knowledge make it promising for systematic understanding complex human diseases at modules level. Based on Gene Ontology, a large number automatic tools have been developed the analysis biological interpretation microarray data. Results Different from existing such as Onto-Express FatiGO, we develop tool named GO-2D identifying 2-dimensional based combined...
The effects of the manganese (Mn) supplemented diets on level superoxide anions (O-2) in hemolymph, and activity dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX) muscle Neocaridina heteropoda were investigated. Manganese sulfate (MnSO4) was added to a basal diet at 0, 20, 40, 60, 80, or 100 μg/g. Diets fed triplicate groups shrimp (0.30±0.11 g, 1.4±0.1 cm) recirculating freshwater rearing system for 30 days. Mn concentration water, monitored during feeding, 1.00±0.02 μg/l. O-2...
Amid the genomic data explosion, phylogenomic analysis has resolved tree of life different organisms, including fungi. Genome-wide clustering also been conducted based on gene content that can lighten issue unequal evolutionary rate genes. In this study, using fungal species as models, we performed and protein-content (PC)-based analysis. The obtained sequence reflects phylogenetic trajectory examined species. However, 15 PC-based trees constructed from Pfam matrices whole genomes, four...