A5025995643- Aquaculture Nutrition and Growth
- Crustacean biology and ecology
- Invertebrate Immune Response Mechanisms
- Glycosylation and Glycoproteins Research
- Animal Genetics and Reproduction
- Neurobiology and Insect Physiology Research
- Environmental Toxicology and Ecotoxicology
- Reproductive biology and impacts on aquatic species
- Monoclonal and Polyclonal Antibodies Research
- Genetic diversity and population structure
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Aquaculture disease management and microbiota
- Physiological and biochemical adaptations
- Constructed Wetlands for Wastewater Treatment
- Identification and Quantification in Food
- HIV Research and Treatment
- Natural product bioactivities and synthesis
- Ion channel regulation and function
- HIV/AIDS drug development and treatment
- Coastal wetland ecosystem dynamics
- Algal biology and biofuel production
- Environmental Quality and Pollution
- Healthcare and Venom Research
- Signaling Pathways in Disease
- HER2/EGFR in Cancer Research
Hebei University
2016-2025
Henan University
2024
Hebei University of Technology
2021
Institute of Biophysics
2021
University of Washington
2009
Fred Hutch Cancer Center
2009
Wuhan Institute of Virology
2007
Chinese Academy of Sciences
2007
Adjuvant diet therapy is an important means of comprehensive treatment cancer. It recognized by patients for its high safety, painlessness, and ease to operate. However, the development adjuvant dietary limited unclear targets anticancer mechanisms. In this work, caffeic acid was found as inhibitor TMEM16A with IC50 29.47 ± 3.19 μM fluorescence quenching whole-cell patch-clamp experiments. Caffeic regulated proliferation, migration, apoptosis lung cancer cells targeting TMEM16A, which...
New human immunodeficiency virus type 1 (HIV-1) diagnoses are increasing rapidly in Hebei. The aim of this study presents the most extensive HIV-1 molecular epidemiology investigation Hebei province China thus far. We have carried out systematic cross-sectional based on newly diagnosed positive individuals 2013, and characterized full length gag-partial pol gene sequences whole Nine genotypes sequence were identified among 610 naïve individuals. four main circulating recombinant form...
Hepatic cirrhosis is the final stage of liver dysfunction, characterized by diffuse fibrosis, which main response to injury. This study investigate effects ursolic acid (UA) on functions and fibrosis in bile duct ligation (BDL) mice determine underlying mechanisms.Cultured hepatocytes were treated with lipopolysaccharide (LPS) presence or absence UA. The reactive oxygen species (ROS) level, protein levels IκBα, iNOS Cox-2, NF-κB activation detected, respectively. C57/BL6 AMP-activated kinase...
Background : Effective anticancer therapy can be achieved by identifying novel tumor-specific drug targets and screening of new drugs. Recently, TMEM16A has been identified to overexpressed in lung adenocarcinoma, inhibitors showed obvious antitumor efficacy. Methods YFP fluorescence quenching whole-cell patch clamp experiments were used explore the inhibitory effect silibinin on TMEM16A. Molecular docking site-directed mutagenesis performed confirm binding sites MTT assay, wound healing...
Lung cancer has the highest rate of incidence and mortality among all cancers. Most chemotherapeutic drugs used to treat lung cause serious side effects are susceptible drug resistance. Therefore, exploring novel therapeutic targets for is important. In this study, we evaluated potential TMEM16A as a target cancer. Homoharringtonine (HHT) was identified natural product inhibitor TMEM16A. Patch-clamp experiments showed that HHT inhibited activity in concentration-dependent manner....
During spermatogenesis in most animals, the basic proteins associated with DNA are continuously changing and somatic-typed histones partly replaced by sperm-specific histones, which then successively transition protamines. With replacement of sperm nuclear proteins, nuclei progressively undergo chromatin condensation. The Chinese Mitten Crab (Eriocheir sinensis) is also known as hairy crab or river (phylum Arthropoda, subphylum Crustacea, order Decapoda, family Grapsidae). spermatozoa this...
Abstract The swimming crab, Portunus trituberculatus , is one of the main aquaculture species in Chinese coastal regions due to its palatability and high economic value. To obtain a better understanding genetic diversity P. Bohai Sea, present study used 40 SSR loci investigate population structure 420 individuals collected from seven populations Sea. Genetic parameters revealed low level cultured ( SI = 1.374, He 0.687, PIC 0.643) comparison with wild ≥ 1.399, 0.692, 0.651). differentiation...
To investigate the role of JAK1/STAT3/KHSRP axis in mediating regulatory effect LINC00626 on progression esophagogastric junction adenocarcinoma.
By comparative analysis of histomorphology and AChE activity, the changes physiological biochemical parameters were determined in zebrafish embryos larvae dealt with atrazine (ATR) at different concentrations (0.0001, 0.001, 0.01, 0.1, 1 mg/L). This study showed that development sarcomere arrangement white muscle myofibers affected by ATR significantly length shortened. Further results activity juvenile fish which was treated downregulated, can indicate innervation efficiency to impaired....
In the present study, transplantation of bone marrow-derived mesenchymal stem cells modified with brain-derived neurotrophic factor gene into lateral ventricle a rat model Alzheimer's disease, resulted in significant attenuation nerve cell damage hippocampal CA1 region. Furthermore, and tyrosine kinase B mRNA protein levels were significantly increased, learning memory improved. Results indicate that can improve cognitive function possibly by increasing hippocampus.