A5100369871- Advanced Fiber Laser Technologies
- Photonic Crystal and Fiber Optics
- Laser-Matter Interactions and Applications
- Advanced Fiber Optic Sensors
- Heavy Metal Exposure and Toxicity
- Per- and polyfluoroalkyl substances research
- Solid State Laser Technologies
- Atmospheric chemistry and aerosols
- Air Quality and Health Impacts
- Radio Frequency Integrated Circuit Design
- Heavy metals in environment
- Chemical and Physical Studies
- Atmospheric Ozone and Climate
- Thyroid Disorders and Treatments
- Genomics and Chromatin Dynamics
- Carbohydrate Chemistry and Synthesis
- Liver Disease Diagnosis and Treatment
- Radioactivity and Radon Measurements
- Epigenetics and DNA Methylation
- Nuclear physics research studies
- Toxic Organic Pollutants Impact
- Protein Degradation and Inhibitors
- Antiplatelet Therapy and Cardiovascular Diseases
- Immune Cell Function and Interaction
- Nuclear Physics and Applications
Peking University
2015-2025
Peking University International Hospital
2025
Nanjing University
2020-2025
State Key Laboratory of Pollution Control and Resource Reuse
2020-2025
Nanjing Medical University
2018-2025
Oscilla Power (United States)
2024
Seattle University
2024
Jiangsu Province Hospital
2018-2024
Sun Yat-sen University
2024
State Key Laboratory of Oncology in South China
2024
Tumor-reactive CD8+ tumor-infiltrating lymphocytes (TILs) represent a subtype of T cells that can recognize and destroy tumor specifically. Understanding the regulatory mechanism tumor-reactive has important therapeutic implications. Yet DNA methylation status this cell not been elucidated.In study, we segregate bystander TILs, as well naïve effector memory subtypes controls from colorectal cancer patients, to compare their transcriptome methylome characteristics. Transcriptome profiling...
Dynamic combinatorial library (DCL) has emerged as an efficient tool for ligand discovery and become important modality in biomedical research. However, the applications of DCLs have been significantly hampered by low diversity limited analytical methods capable processing large libraries. Here, we report a strategy that addressed this limitation can select cooperatively binding small-molecule pairs from large-scale dynamic Our approach is based on DNA-mediated hybridization, DNA-encoding,...
An Yb-doped, all-polarization-maintaining fiber laser oscillator with a nonlinear amplifying loop mirror is presented in this letter. A new compact non-reciprocal phase shifter biased was engaged inside the laser, which results low threshold and stable mode locking. With 2.8-nm filter cavity, locked output power 4.1 mW repetition rate of 31.35 MHz at pump 80 mW. The spectral bandwidth pulse 3.1 nm. pulsewidth direct dechirped are 2.13 ps 538 fs, respectively. plays significant role spectrum width.
Recently, perfluoroalkyl substances (PFASs) have received great attention from both academia and the industry due to their persistence health risks. Here, we developed a simple ternary self-assembled micelle composite, consisting of photosensitive substance (indole acetic acid, IAA), cationic surfactant (cetyltrimethylammonium bromide), contaminant (PFAS). Owing rapid hydrated electron transfer IAA PFAS in micelle, degradation defluorination were greatly enhanced even under ambient...
The eukaryotic genome is folded into higher-order conformation accompanied with constrained dynamics for coordinated functions. However, the molecular machinery underlying these hierarchically organized three-dimensional (3D) chromatin architecture and remains poorly understood. Here by combining imaging sequencing, we studied role of lamin B1 in dynamics. We found that depletion leads to detachment lamina-associated domains (LADs) from nuclear periphery global redistribution decompaction....
We report a mode-locked fiber laser working at 1 GHz fundamental repetition rate. The delivers 600 mW average power pump of 1800 mW. pulse spectrum bandwidth was 23 nm to support 64 fs near-transform-limited pulses. An octave-spanning supercontinuum from 590 1350 generated in tapered photonic crystal solely with the fiber-laser output, without amplifiers. A 30 dB fceo beat signal detected via f-to-2f interferometer.
Rationale: Polycomb repressive complex 2 is a major epigenetic repressor that deposits methylation on histone H3 lysine 27 (H3K27me) and controls differentiation function of many cells, including cardiac myocytes. EZH1 EZH2 are alternative catalytic subunits with partial functional redundancy. The relative roles in heart development regeneration unknown. Objective: We compared the versus neonatal regeneration. Methods Results: Heart was normal Ezh1 −/− ( Ezh 1 knockout) Ezh2 f/f ::cTNT −Cre...
UHF RFID reader transceiver for Chinese local standard (840-845 MHz and 920-925 MHz), in concord with the protocols of EPC Class-1 Gen-2 ISO/IEC 18000-6C, is presented. A highly linear RF front-end low flicker noise, an on-chip self-jammer cancellation (SC) circuit fast time-varying cut-off frequency a DC-offset (DCOC) are proposed to deal large receiver. In presence 22 dBm PA output power, receiver achieves sensitivity -79 including 15 dB loss directional coupler. CMOS class-AB integrated...
A new wideband predictive ldquodouble-pirdquo equivalent-circuit model for on-chip spiral inductors is presented, in which the parameters are analytically calculated with layout and process parameters. In model, five major parasitic effects, including skin effect, proximity distributed substrate capacitive loss, inductive implemented together. Considering effect simultaneously, a equation of high-frequency resistance proposed, accordingly, two coupled transformer loops developed,...
Over 100 million children worldwide suffer from mental distress, with incidence rates steadily increasing. However, the combined impacts of air pollution and non-optimal temperature on schoolchildren's health, as well disparities across urban rural schools between genders, remain insufficiently explored. Utilizing 95,658 distress records school in eastern China, we developed nine composite exposure scenarios to evaluate health short-term (0-14 days) particulate matter (PM) (i.e., PM1, PM2.5,...
We report a core-pumped all-normal dispersion mode-locked Nd-doped fiber laser at 910 and 935 nm. The pulse is compressed to 198 fs, the energy 1.3 nJ. slope efficiency more than 14%. This tested as optical source for two-photon fluorescence imaging of pollen.
Get PDF Email Share with Facebook Tweet This Post on reddit LinkedIn Add to CiteULike Mendeley BibSonomy Citation Copy Text Chen Li, Guizhong Wang, Tongxiao Jiang, Aimin and Zhigang Zhang, "750 MHz fundamental repetition rate femtosecond Yb:fiber ring laser," Opt. Lett. 38, 314-316 (2013) Export BibTex Endnote (RIS) HTML Plain alert Save article
Air pollution exposure has been linked to a variety of adverse health outcomes among minors; yet little is known about the associated inequity across regions and schools. Here, we assessed unequal burden particulate matter minors 10,358 schools in China through 12,439,232 individual records. Our findings highlight persistent risks with superlinear concentration–response patterns following inverted U-shaped risk trends, that each 10 μg/m3 increase PM2.5 resulted 4.1% (3.9–4.2%) additional...
Objective: To test the hypothesis that peripheral nerve block (PNB) use might be associated with improved perioperative outcomes following major surgery. Summary Background Data: PNB has been used to improve postoperative analgesia. Methods: This was a retrospective cohort study propensity score matching. We included patients aged ≥65 years who underwent (≥2 h) non-cardiac thoracic and abdominal surgery under general anesthesia. Data were analyzed according whether received or not during Our...
Modern agriculture demands precise genomic prediction to accelerate elite crop breeding, yet current methods predominantly analyze single nucleotide polymorphisms (SNPs) while neglecting the regulatory context of surrounding sequences. To overcome these limitations, two novel feature embedding modes(SNP-context and whole-genome) capture both local global genetic information. These were implemented through a unified computational framework combining DNABERT-2 cross-species foundation model...