A5100876910- Oral Health Pathology and Treatment
- Oral and Maxillofacial Pathology
- Autophagy in Disease and Therapy
- Obstructive Sleep Apnea Research
- Salivary Gland Tumors Diagnosis and Treatment
- Tracheal and airway disorders
- Hedgehog Signaling Pathway Studies
- Cancer-related molecular mechanisms research
- Neuroscience of respiration and sleep
- Immune cells in cancer
- Endoplasmic Reticulum Stress and Disease
- Dental Trauma and Treatments
- Head and Neck Cancer Studies
- Pediatric health and respiratory diseases
- Cancer and Skin Lesions
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Gastric Cancer Management and Outcomes
- dental development and anomalies
- Autoimmune and Inflammatory Disorders
- Dental Health and Care Utilization
- Alkaloids: synthesis and pharmacology
- Studies on Chitinases and Chitosanases
- Neurological diseases and metabolism
State Grid Corporation of China (China)
2024-2025
Capital Medical University
2023-2025
Peking University
2016-2024
Fudan University
2019-2024
Shanghai Stomatological Hospital
2013-2024
King University
2022-2023
Key Laboratory of Guangdong Province
2023
Beijing Friendship Hospital
2023
Peking University Third Hospital
2023
Chinese PLA General Hospital
2023
Background Oral leukoplakia (OL) is the best-known potentially malignant disorder. The objective of current study was to evaluate clinicopathological factors predictive outcome in a large cohort patients with OL, and report our experience early detection events. Methods A total 320 biopsy-proven OL were retrospectively reviewed from institution who had mean follow-up 5.1 years. Data on patient lesion at initial diagnosis underwent sequential biopsies reviewed. Multiple indicates > = 3 times...
Background An epidemiological study on the oral mucosal lesions ( OML s) in general population from China was scarce. The objective of this to investigate prevalence and distribution s Shanghai, evaluate their association with demographic factors smoking/drinking habits based a large scaled wide spectrum. Methods In population‐based cross‐sectional study, 11054 community‐dwelling individuals (M/F: 5140/5914; age range, 1–96 years) were randomly selected examined according WHO criteria....
The objective is to investigate the influence of PM2.5 exposure on peripheral blood lymphocyte subsets in pregnant mice and antagonism quercetin adverse effects induced by exposure. Pregnant were randomly divided into control group, model group 3 intervention groups. Dams all groups except exposed suspension intratracheal instillation gestational day (GD) 3, 6, 9, 12 15. Meanwhile, each dam was given 0.15% carboxymethylcellulose sodium (CMCS) (control & group) different doses (quercetin...
To the Editor: Autophagy is an evolutionarily conserved lysosome-mediated degradation process in eukaryotic cells that crucial for maintaining cell homeostasis under normal conditions. involves formation of a crescent-shaped phagophore (or isolation membrane [IM]), which expands and closes to form double-membraned autophagosome. The autophagosome delivered late endosome/lysosomes sequestrated materials. Autophagic dysfunction can cause tumors neurodegenerative, cardiovascular, autoimmune...
Abstract BACKGROUND: Although oral leukoplakia (OL) is the best‐known potentially malignant disorder, risk of OL transformation difficult to assess. ATP‐binding cassette, G2 subfamily (ABCG2) and BMI‐1 are stem cell markers that have been found be associated with head neck tumorigenesis. The objective current study was evaluate usefulness ABCG2 in predicting transformation. METHODS: In a retrospective cohort 135 patients from institution who had mean follow‐up 5.5 years, 32 developed cancer...
Interleukin- (IL-) 22 is the signature cytokine of T-helper (Th) cells, and IL-23 required for IL-22 production. The objective this study was to examine immunoexpression in archival paraffin-embedded biopsy specimens from oral LP (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>42</mml:mn></mml:math>) cutaneous id="M2"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>38</mml:mn></mml:math>) against normal control tissues. results showed...
J Oral Pathol Med (2013) 42 : 148–153 Background: erythroplakia (OE) is a notoriously aggressive oral pre‐malignant lesion with high tendency to cancer development, but its biological behavior largely unknown. The objective of this study was determine the expression stem cell markers ALDH1 and Bmi1 in OE their correlation malignant transformation OE. Methods: In retrospective case–control study, patterns were determined using immunohistochemistry samples from 34 patients OE, including...
Background: Polypharmacology is emerging as the next paradigm in drug discovery. However, considerable challenges still exist for polypharmacology modeling. In this study, we developed a rational design to identify highly potential targets (HPTs) polypharmacological drugs, such berberine. Methods and Results: All proven co-crystal structures locate berberine active cavities of redundancy aromatic, aliphatic, acidic residues. The side chains from residues provide hydrophobic electronic...
The E3 ubiquitin ligase RING finger protein 115 (RNF115), also known as breast cancer-associated gene 2 (BCA2), has been linked with the growth of some cancers and immune regulation, which is negatively correlated prognosis. Here, it demonstrated that RNF115 deletion can protect mice from acute liver injury (ALI) induced by treatment lipopolysaccharide (LPS)/D-galactosamine (D-GalN), evidenced decreased levels alanine aminotransaminase, aspartate transaminase, inflammatory cytokines (e.g.,...
Fructus ligustri Lucidi (FLL) is the fruit of Ligustrum lucidum Ait and a traditional Chinese medicine, primarily known for its role in osteoporosis prevention treatment. The present study aimed to elucidate effect underlying mechanism action ethanol extract FLL on osteoclast differentiation bone resorption, identify active compounds within it. RAW264.7 murine monocyte/macrophage cells were stimulated with receptor activator nuclear factor κB ligand (RANKL) induce vitro. demosntrated that...
(1) Background: We aim to construct a machine learning (ML) algorithm predict the risk of distant metastasis (DM) T1 and T2gallbladder cancer (GBC); (2) Demographic clinical pathological data T2 GBC patients were extracted from National Institutes Health (NIH)’s Surveillance, Epidemiology, End Results (SEER) database between 2004 2015 develop seven ML models. Models evaluated based on accuracy, precision, recall rate, F1- score, area under receiver operating characteristic curve (AUC); (3)...
Abstract ULK1 is crucial for initiating autophagosome formation and its activity tightly regulated by post-translational modifications protein-protein interactions. In the present study, we demonstrate that TMEM189 (Transmembrane protein 189), also known as plasmanylethanolamine desaturase 1 (PEDS1), negatively regulates proteostasis of autophagy activity. TMEM189-overexpressed cells, autophagesome impaired, while knockdown increases cell autophagy. Further investigation reveals interacts...
Purpose: Sevoflurane is the preferred anesthetic agent for induction and maintenance of ambulatory surgery due to its property fast onset recovery. However, it has been recognized as one major contributors emergence delirium. The aim this study was evaluate preventive effect intranasal dexmedetomidine on occurrence delirium in pediatric patients under general anesthesia with sevoflurane. Patients Methods: Ninety undergoing dental rehabilitation sevoflurane were enrolled study. divided into...
Abstract Autophagy is a highly conserved lysosome-dependent degradation system in eukaryotic cells. This process removes long-lived intracellular proteins, damaged organelles, and recycles biological material to maintain cellular homeostasis. Dysfunction of autophagy triggers wide spectrum human diseases, including cancer neurodegenerative diseases. In the present study, we show that RNF115, an E3 ubiquitin ligase, regulates autophagosome–lysosome fusion autophagic under both...
Abstract Host defense systems can invade viral infection through immune responses and cellular metabolism. Recently, many studies have shown that metabolism be reprogrammed N 6 ‐methyladenosine (m A) modifications during infection. Among of them, methyltransferase like‐14 enzyme (METTL14) plays an important role in m A RNA modification, yet its antiviral function still remains unclear. In this work, it is uncovered metal–protein nanoparticles designated GSTP1‐MT3(Fe 2+ ) (MPNP) polarize...
(1) Background: This study seeks to employ a machine learning (ML) algorithm forecast the risk of distant metastasis (DM) in patients with T1 and T2 gallbladder cancer (GBC); (2) Methods: Data diagnosed GBC was obtained from SEER, encompassing period 2004 2015, were utilized apply seven ML algorithms. These algorithms appraised by area under receiver operating characteristic curve (AUC) other metrics; (3) Results: involved 4371 total. Out these patients, 764 (17.4%) cases progressed develop...