A5108419143- Medicinal Plant Pharmacodynamics Research
- Natural product bioactivities and synthesis
- Cancer-related molecular mechanisms research
- Pluripotent Stem Cells Research
- Glutathione Transferases and Polymorphisms
- Nitric Oxide and Endothelin Effects
- Adipose Tissue and Metabolism
- Cancer Cells and Metastasis
- Peroxisome Proliferator-Activated Receptors
- Ginseng Biological Effects and Applications
- Pharmacogenetics and Drug Metabolism
- Liver physiology and pathology
- Drug-Induced Hepatotoxicity and Protection
- Nephrotoxicity and Medicinal Plants
- Bioactive natural compounds
- Medicinal Plants and Neuroprotection
- Estrogen and related hormone effects
- Quinazolinone synthesis and applications
- Reproductive Biology and Fertility
- Genomics, phytochemicals, and oxidative stress
- Pharmacological Effects of Natural Compounds
- Phytoestrogen effects and research
- MicroRNA in disease regulation
- Signaling Pathways in Disease
- Phytochemical and Pharmacological Studies
Peking University
2005-2025
Zhejiang University
2009-2022
China Electronics Technology Group Corporation
2022
Shanghai University
2022
Institute of Pharmacology
2008-2021
Innovation Team (China)
2016
Guangdong Ocean University
2009
National Natural Science Foundation of China
2008
Toranomon Hospital
2008
Chinese National Human Genome Center
2005
Dietary vitamin E (VE) is known to regulate gene expression by altering mRNA concentrations. Recently, microRNA (miRNA) have been discovered as a means of posttranscriptional regulation. Since the effect VE on miRNA regulation unknown, we fed rats for 6 months diets deficient or sufficient in and determined hepatic concentrations involved processes previously associated with (lipid metabolism, miRNA‐122a; cancer inflammation, miRNA‐125b). VE‐deficiency resulted reduced miRNA‐122a miRNA‐125b....
We previously reported that treatment of icariin could significantly induce cardiomyocyte differentiation murine embryonic stem (ES) cells in vitro. In the present study, exact activity initiated by was further confirmed and underlying molecular mechanism investigated. found efficiently stimulated only if administrated between days 5 8 course, which indicated with elevated percentage embryoid bodies (EB) beating areas up- regulated expression alpha-actinin troponin T. Exposure triggered...
Abstract The significant promoting effects of some prenylflavonoids on cardiac differentiation mouse embryonic stem (ES) cells via reactive oxygen species (ROS) signaling pathway were investigated. most effective was facilitated by icariin (ICA), followed icaritin (ICT), while desmethylicaritin (DICT) displayed the weakest but still inducible effect. Contrarily, DICT demonstrated strongest anti‐oxidative activity ICA only little in vitro, which well matched with hydroxyl (OH) numbers and...
Previous studies suggest that treatment with icariin (ICA) combined Panax notoginseng saponins (PNS) improved behavior and cholinergic system disorders followed by amyloid beta-peptide(25-35) lateral ventricle injection in rats. The present study investigated whether administration of ICA + PNS had preventive therapeutic effects on bilateral common carotid arteries (CCA) occlusion-induced cerebral ischemia-reperfusion (IR) injury Male Sprague-Dawley rats were divided randomly as follows:...
To the Editor: Autophagy is an evolutionarily conserved lysosome-mediated degradation process in eukaryotic cells that crucial for maintaining cell homeostasis under normal conditions. involves formation of a crescent-shaped phagophore (or isolation membrane [IM]), which expands and closes to form double-membraned autophagosome. The autophagosome delivered late endosome/lysosomes sequestrated materials. Autophagic dysfunction can cause tumors neurodegenerative, cardiovascular, autoimmune...
The present investigation was undertaken to determine the protective effects of flavonoids from seabuckthorn (FSBT), a traditional Chinese medicine, on endothelial cell line EA.hy926 injury induced by oxidized low-density lipoprotein (ox-LDL). Possible mechanisms were then explored. quercetin and isorhamnetin, 2 major components FSBT, examined as well. Indices such viability, lactate dehydrogenase, nitric oxide (NO), superoxide dismutase, measured. Reverse transcription polymerase chain...
Bee pollen of Brassica campestris L. is widely used in China as a natural food supplement and an herbal medicine strengthening the body's resistance against diseases including cancer. The present study was carried out to investigate effect steroid fraction chloroform extract from bee on human cancer cell viability. Our studies show that among nine lines different origin (PC-3, LNCaP, MCF-7, Hela, BEL-7402, BCG-823, KB, A549 HO8910), this displayed strongest cytotoxicity prostate PC-3 cells....
Summary Background Tight junction protein degradation is a principal characteristic of the blood–brain barrier ( BBB ) damage that occurs during brain ischemia. Aims We investigated mechanisms occludin underlie permanent middle cerebral artery occlusion (p MCAO in rats. Methods and Results Western blot C o‐immunoprecipitation data indicated ubiquitination after p , which was consistent with ZO ‐1 penumbra regions as observed at 24 h . further candidate protease(s) responsible for The...