A5043904965- Ovarian function and disorders
- Reproductive Biology and Fertility
- Cancer-related molecular mechanisms research
- Reproductive System and Pregnancy
- RNA modifications and cancer
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Plant Gene Expression Analysis
- Endometriosis Research and Treatment
- Extracellular vesicles in disease
- Plant Molecular Biology Research
- Cancer, Hypoxia, and Metabolism
- Phytochemistry and Bioactive Compounds
- Bioactive natural compounds
- Reproductive Health and Technologies
- RNA Research and Splicing
- Assisted Reproductive Technology and Twin Pregnancy
- Plant biochemistry and biosynthesis
- Phytochemicals and Antioxidant Activities
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Research and Treatments
- Retinoids in leukemia and cellular processes
- Redox biology and oxidative stress
- Epigenetics and DNA Methylation
- Kruppel-like factors research
Wenzhou Medical University
2023-2025
Southern University of Science and Technology
2024
Wuhan University
2024
Institute of Botany
2022-2024
Shenzhen Zhongshan Urological Hospital
2024
Shanghai First Maternity and Infant Hospital
2018-2024
Anhui University
2024
Nanjing Normal University
2024
Shanghai Jiao Tong University
2012-2023
National Clinical Research Center for Digestive Diseases
2023
Abstract Colorectal cancer (CRC) therapy efficiency can be influenced by the microbiota in gastrointestinal tract. Compared with traditional intervention, prebiotics delivery into gut is a more controllable method for modulatory therapy. Capecitabine (Cap), first-line chemotherapeutic agent CRC, lacks carrier that prolong its half-life. Here, we construct Cap-loaded nanoparticle using prebiotic xylan-stearic acid conjugate (SCXN). The oral administration of SCXN delays drug clearance blood...
Abstract Exosomes have recently emerged as key mediators of different physiological and pathological processes. However, there has been few report about proteomic analysis exosomes derived from human follicular fluid their association with the occurrence PCOS. Herein, we used TMT‐tagged quantitative approach to identify profiles in PCOS patients healthy controls. We identified 662 proteins ovarian fluid. Eighty‐six differently expressed ( P < .05) were found between women. The alterations...
Abstract The development of chemoresistance remains a major challenge that accounts for colorectal cancer (CRC) lethality. Dichloroacetate (DCA) was originally used as metabolic regulator in the treatment diseases; here, DCA assayed to identify mechanisms underlying CRC. We found markedly enhanced chemosensitivity CRC cells fluorouracil (5-FU), and reduced colony formation due high levels apoptosis. Using microarray assay, we noted miR-149-3p involved CRC, which modulated by wild-type p53...
Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder in reproductive women characterized by polycystic ovaries, hyperandrogenism chronic anovulation. Abnormal folliculogenesis considered as characteristic of PCOS. Our aim to identify the altered circRNA expression profile exosomes isolated from follicular fluid (FF) PCOS patients investigate molecular function exosomal circRNA, vital mediator microenvironment, aetiology pathobiology In this study, FF were compared...
Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder in women. The developmental competence of oocytes embryos PCOS patients reduced to certain extent (comparing non-PCOS patients, the high quality embryo rate was decreased by 16% from data our centre) during vitro fertilization (IVF) process. Cross-talk between oocyte cumulus cells critical for maturation competence. In this study, we have evaluated transcription specific genes harvested pre-ovulatory follicles...
Previous studies have indicated that high expression of lactate dehydrogenase A (LDHA) exists in many human cancers. Recently, several reports showed silencing or inhibition LDHA could suppress metastasis cancer including renal cell carcinoma (RCC). However, the mechanism remains unknown. The role RCC migration and invasion was investigated using immunohistochemistry, western blotting, Transwell scratch assays, vivo experiment. influence on Warburg effect also by activity production assay....
Abstract Exploring novel anticancer drugs to optimize the efficacy may provide a benefit for treatment of colorectal cancer (CRC). Disulfiram (DSF), as an antialcoholism drug, is metabolized into diethyldithiocarbamate-copper complex (CuET) in vivo, which has been reported exert effects on various tumors preclinical studies. However, little known about whether CuET plays anti-cancer role CRC. In this study, we found that had marked effect suppressing CRC progression both vitro and vivo by...
Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder in women. The abnormalities of intra-ovarian paracrine interactions may change the microenvironment for oocyte development during folliculogenesis process reduce developmental competence oocytes PCOS patients who are suffering from anovulatory infertility pregnancy loss. In this microenvironment, cross talk between an surrounding cumulus cells (CCs) critical achieving competence. aim our study was to investigate...
Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder in women characterised by polycystic ovaries, hyperandrogenism chronic anovulation. Although the clinical biochemical signs of PCOS are typically heterogeneous, abnormal folliculogenesis considered characteristic PCOS. Our aim to identify altered miRNA mRNA expression profiles cumulus cells patients investigate their molecular function aetiology pathophysiology In this study, cell samples isolated from five control...
Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder in women. An lncRNA, namely, Prader-Willi region nonprotein coding RNA 2 (PWRN2), was up-regulated the cumulus cells of patients with PCOS. However, molecular mechanism PWRN2 PCOS remains largely unknown.In this study, expression levels were tested through qRT-PCR analysis to confirm its potential roles oocyte nuclear maturation A PWRN2-mediated ceRNA network constructed based on three microarray datasets...
Reactive astrogliosis is a critical process in the development of ischemic stroke. However, precise mechanism by which reactive changes pathogenesis stroke remains elusive. Sterile alpha and TIR motif-containing 1 protein (SARM1) plays key role axonal degeneration involved different cell death programs that regulate neuronal survival. The present study investigated SARM1 regulating neurological function after whole-body knockout (SARM1-/-) mice. SARM1-/- mice showed significantly smaller...
Chemoresistance is responsible for most colorectal cancer (CRC) related deaths. In this study, we found that dichloroacetate (DCA), a pyruvate dehydrogenase kinase (PDK) inhibitor, can be used as sensitizer oxaliplatin (L-OHP) chemoresistant CRC cells. The aim of study was to explore the ability DCA overcome L-OHP resistance in cells and identify underlying molecular mechanisms. We sensitizes L-OHP-induced cytotoxic effects by inhibiting clone formation capacity promoting cell apoptosis. A...
Abstract Background Chemoresistance remains a critical event that accounts for colorectal cancer (CRC) lethality. The aim of this study is to explore the ability dichloroacetate (DCA) increase chemosensitivity in CRC and molecular mechanisms involved. Methods effects combination treatment DCA oxaliplatin (L-OHP) were analysed both vitro vivo. DCA-responsive proteins AMPK pathway enriched using proteomic profiling technology. effect on CAB39–AMPK signal was analysed. In addition, miRNA...
Five series of 37 new acylate and epoxide derivatives (3–39) Euphorbia factor L3, a lathyrol diterpene isolated from lathyris, were designed by modifying the hydroxyl moiety C-3, C-5, or C-15. Chemoreversal effects acylates on multidrug resistance (MDR) evaluated in breast cancer multidrug-resistant MCF-7/ADR cells that overexpress P-glycoprotein (P-gp). Eight exhibited greater chemoreversal ability than verapamil (VRP) against adriamycin (ADR) resistance. Compounds 19 25 4.8 4.0 times,...
Polycystic ovary syndrome (PCOS) has been recognized as a common reproductive and endocrine disorder. Long noncoding RNA (lncRNA) steroid receptor activator (SRA) affects multiple biological processes. However, it is not known whether lncRNA SRA associated with PCOS. In the study, we measured expression level of in PCOS patients, analyzed association between key parameters LncRNA was significantly higher women than that controls. There significant positive correlation BMI group. Furthermore,...
SMARCA5 (circSMARCA5) is involved in the occurrence of different cancers, but its role prostate cancer carcinogenesis and metastatic transformation remains elusive. Thus, we evaluated circSMARCA5 functional relevance associated molecular mechanism. First, expression function this were evaluated. To determine miR-181b-5p/miR-17-3p target clarify how regulates miR-181b-5p-TIMP3 miR-17-3p-TIMP3 axis, RNA immunoprecipitation, biotin-coupled microRNA capture, luciferase reporter, Western blot,...
New-onset diabetes mellitus has a rough correlation with pancreatic cancer (PaC), but the underlying mechanism remains unclear.This study aimed to explore exosomal microRNAs and their potential role in PaC-induced β-cell dysfunction.The β cells were treated isolated exosomes from PaC cell lines, SW1990 BxPC-3, before measuring glucose-stimulated insulin secretion (GSIS), validating that BxPC-3 might disrupt GSIS of both line MIN6 primary mouse islets.The difference expression profiles...