A5017972700- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- RNA Research and Splicing
- Extracellular vesicles in disease
- Cancer, Hypoxia, and Metabolism
- Animal Virus Infections Studies
- Autophagy in Disease and Therapy
- interferon and immune responses
- Lattice Boltzmann Simulation Studies
- Neonatal Respiratory Health Research
- Vitamin D Research Studies
- Genetics and Neurodevelopmental Disorders
- Virus-based gene therapy research
- Cancer-related Molecular Pathways
- Neuroscience of respiration and sleep
- Epigenetics and DNA Methylation
- Model Reduction and Neural Networks
- Cancer Mechanisms and Therapy
- Hippo pathway signaling and YAP/TAZ
- Inflammasome and immune disorders
- Gestational Diabetes Research and Management
- Heme Oxygenase-1 and Carbon Monoxide
- Advanced Biosensing Techniques and Applications
Johns Hopkins University
2011-2025
Huashan Hospital
2025
Fudan University
2025
Wuhan Ship Development & Design Institute
2024
Jiangsu University
2024
Shanghai Tenth People's Hospital
2017-2023
Tongji University
2017-2023
Xuzhou Medical College
2020-2022
Tibet Autonomous Region People's Hospital
2021-2022
Fudan University Shanghai Cancer Center
2017-2022
Abstract The development of chemoresistance remains a major challenge that accounts for colorectal cancer (CRC) lethality. Dichloroacetate (DCA) was originally used as metabolic regulator in the treatment diseases; here, DCA assayed to identify mechanisms underlying CRC. We found markedly enhanced chemosensitivity CRC cells fluorouracil (5-FU), and reduced colony formation due high levels apoptosis. Using microarray assay, we noted miR-149-3p involved CRC, which modulated by wild-type p53...
ABSTRACT The bacterium Pseudomonas aeruginosa is able to invade lung epithelial cells and survive intracellularly. During this process, it secretes outer membrane vesicles (OMVs), however, currently unclear how OMVs from P. (PA-OMVs) affect their impact on oxidative stress, autophagy, other physiological activities of cells. In study, we found that PA-OMVs activated stress autophagy in We demonstrated the NLRP3 (NLR family, pyrin domain containing 3) inhibitor MCC950 can enhance induced by...
It is commonly agreed that there an association of chronic inflammation with tumorigenesis. COX-2, a key regulator inflammation-producing prostaglandins, promotes cell proliferation and growth; thus, overexpression COX-2 often found in tumor tissues. Therefore, better understanding the regulatory mechanism(s) could lead to novel targeted cancer therapies. In this study, we investigated mechanism microRNA-101 (miR-101)-regulated expression therapeutic potential exogenous miR-101 for...
Triple-negative breast cancer (TNBC) has the worst prognosis of all subtypes (BC), with limited options for conventional therapy and no targeted therapies. MicroRNAs (miRNAs) are small noncoding RNAs that negatively regulate gene expression. In this study, we aimed to determine whether two members miR-200 family, miR-200b-3p miR-429-5p, involved in BC cell proliferation motility elucidate their target genes pathways. We performed a meta-analysis reveals down-regulated expression miR-429-5p...
Breast cancer (BrCa) is the malignant tumor that most seriously threatens female health; however, molecular mechanism underlying its progression remains unclear. Here, we found conditional deletion of hypermethylated in 1 (HIC1) mouse mammary gland might contribute to premalignant transformation early stage formation. Moreover, chemokine (C-X-C motif) ligand 14 (CXCL14) secreted by HIC1-deleted BrCa cells bound cognate receptor GPR85 on fibroblasts microenvironment and was responsible for...
Abstract Exploring novel anticancer drugs to optimize the efficacy may provide a benefit for treatment of colorectal cancer (CRC). Disulfiram (DSF), as an antialcoholism drug, is metabolized into diethyldithiocarbamate-copper complex (CuET) in vivo, which has been reported exert effects on various tumors preclinical studies. However, little known about whether CuET plays anti-cancer role CRC. In this study, we found that had marked effect suppressing CRC progression both vitro and vivo by...
Triple-negative breast cancer (TNBC) is known as a highly aggressive subtype of BC due to high rate recurrence and metastasis, poor prognosis lacking effective targeted therapies. Circular RNAs (circRNAs) have been reported participate in the progression TNBC. In this study, we demonstrated that circPRKCI, derived from PRKCI gene, was elevated tissues cell lines, especially The functional investigation showed circPRKCI could significantly promote proliferation migration TNBC vivo vitro....
Abstract Prostate cancer (PCa) is a malignant tumor that seriously threatens men’s health worldwide. Recently, stromal cells in the microenvironment (TME) have been reported to contribute progression of PCa. However, role and mechanism how PCa interact with reshape TME remain largely unknown. Here, using spontaneous prostate adenocarcinoma (PRAD) model driven by loss Pten Hic1 , we found M2 macrophages markedly infiltrated stroma double conditional knockout ( dCKO ) mice compared those...
Abstract Re-expression of an embryonic morphogen, Nodal, has been seen in several types malignant tumours. By far, studies about Nodal’s role colorectal cancer (CRC) remain limited. Ferroptosis is essential for CRC progression, which caused by cellular redox imbalance and characterized lipid peroxidation. Herein, we observed that Nodal enhanced cell’s proliferative rate, motility, invasiveness, epithelial–mesenchymal transition (EMT) vivo vitro. Notably, overexpression induced...
Abstract To evaluate the effects of maternal vitamin D deficiency on body fat and adipogenesis in offspring rats, explore potential mechanism, we constructed a deficient rat model performed metabolic activity evaluation, monitoring, biochemical analysis, assay, methylation microarray RNA-seq for their rats. We found weight (VDD) was gradually higher than that control (CLT) offspring, difference significant since 10 weeks old. When compared with CTL 24 h heat production, peak blood glucose,...
The aim of the present study was to define function microRNA‑424‑5p (miR‑424) in breast cancer cells. investigated level and potential miR‑424 by reverse transcription‑quantitative polymerase chain reaction assays. expression decreased majority human specimens cell lines used study. MTT assay, plate colony formation assay flow cytometry analyses were characterize two types lines. Upregulation inhibited cellular proliferation regulated cycle arresting cells G2/M phase. dual‑luciferase...
Aberrant expression of microRNAs (miRNAs) plays important roles in carcinogenesis and tumor progression. However, the biological role miR-301b triple-negative breast cancer (TNBC) remains unclear. Here we aimed to evaluate mechanisms TNBC cells. was assessed specimens cell lines by quantitative Real-Time PCR (qRT-PCR). cells were transfected with mimics, inhibitors or Cylindromatosis (CYLD) small interfering RNA (siRNA) using Lipofectamine 2000. The functional determined proliferation,...
Chemoresistance is responsible for most colorectal cancer (CRC) related deaths. In this study, we found that dichloroacetate (DCA), a pyruvate dehydrogenase kinase (PDK) inhibitor, can be used as sensitizer oxaliplatin (L-OHP) chemoresistant CRC cells. The aim of study was to explore the ability DCA overcome L-OHP resistance in cells and identify underlying molecular mechanisms. We sensitizes L-OHP-induced cytotoxic effects by inhibiting clone formation capacity promoting cell apoptosis. A...
Abstract Lon protease 1 (LONP1) is an ATP-dependent located in the mitochondrial matrix and plays a crucial role regulating proteostasis, metabolism, cellular stress responses et al. Aberrant LONP1 expression has been found progression of various tumors; however, molecular mechanisms prostate cancer (PCa) remain poorly understood. Here we show that overexpression closely related to adverse clinic pathological features poor prognosis PCa patients. Mechanistically, findings reveal implicated...
Prostate-specific antigen (PSA) test is limited in prostate cancer diagnosis due to its inaccuracy. A new approach which integrates the PSA with miRNA profiling was investigated improve diagnosis. Six cancer-related miRNAs (miR-16, -21, -34c, -101, -125b, -141) were tested five cultured cell lines and 20 human specimens. We found that expression profiles significantly different between nontumorigenic tumorigenic Positive predictive value analysis of increased from 40% 87.5% by integrating...
Melanoma differentiation associated gene 5 (MDA5) and retinoic acid-inducible gene-I (RIG-I) selectively sense cytoplasmic viral RNA to induce an antiviral immune response. Infectious bronchitis virus (IBV) is one of the most important infectious agents in chickens, chicken cells, it can be recognized by MDA5 activate interferon production. RIG-I considered absent chickens. However, absence chickens raises question whether this protein influences response against IBV infection. Here, we...
Abstract The development of prostate cancer (PCa) from androgen-deprivation therapy (ADT) sensitive to castration resistant (CRPC) seriously impacts life quality and survival PCa patients. Emerging evidence shows that long noncoding RNAs (lncRNAs) play vital roles in initiation progression. However, the inherited mechanisms how lncRNAs participate progression treatment resistance remain unclear. Here, we found a RNA LINC00675 was upregulated androgen-insensitive cell lines CRPC patients,...
Dysregulated expression of WW domain-binding protein 2 (WBP2) is associated with poor prognosis in ER+ breast cancer patients. However, its role triple negative (TNBC) has not been previously assessed. Therefore, we aimed to elucidate the functional mechanism WBP2 TNBC cells.qRT-PCR, western blotting, and immunohistochemical staining were used evaluate patient tumors cell lines. HCC1937 MDA-MB-231 cells transiently transfected small interfering RNA (siRNA), miR-613 mimics, or inhibitors...