A5100409328- Autophagy in Disease and Therapy
- Rabies epidemiology and control
- Animal Virus Infections Studies
- Virology and Viral Diseases
- Sirtuins and Resveratrol in Medicine
- Viral gastroenteritis research and epidemiology
- Microbial infections and disease research
- SARS-CoV-2 and COVID-19 Research
- Cancer Immunotherapy and Biomarkers
- Adenosine and Purinergic Signaling
- Viral Infections and Outbreaks Research
- Poxvirus research and outbreaks
- Rheumatoid Arthritis Research and Therapies
- Pregnancy-related medical research
- Chronic Kidney Disease and Diabetes
- Traumatic Brain Injury Research
- Ferroptosis and cancer prognosis
- Viral Infections and Vectors
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- COVID-19 epidemiological studies
- Renal Diseases and Glomerulopathies
- Monoclonal and Polyclonal Antibodies Research
- Gestational Diabetes Research and Management
- Fungal Biology and Applications
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2025
Sichuan University
2019-2025
West China Second University Hospital of Sichuan University
2019-2025
Huazhong University of Science and Technology
2025
Henan Institute of Science and Technology
2025
Xinyang Normal University
2023-2024
Affiliated Hospital of Qingdao University
2019-2024
Southwest University
2022-2024
Qingdao University
2019-2024
Guang’anmen Hospital
2019-2024
Background: Podocyte injury has a direct causal relationship with proteinuria and glomerulosclerosis and, on chronic level, can lead to irreversible disease progression. plays critically decisive role in the development of proteinuric kidney disease. In recent years, research podocyte developed rapidly all over world. However, no report summarized field as whole date. Using bibliometric analysis, this study aimed evaluate current state worldwide last 30 years identify important achievements,...
SARS-CoV and SARS-CoV-2 have been thought to originate from bats. In this study, we screened pharyngeal anal swabs 13 064 bats collected between 2016 2021 at 703 locations across China for sarbecoviruses, covering almost all known southern hotspots, found 146 new bat sarbecoviruses. Phylogenetic analyses of available sarbecoviruses show that there are three different lineages-L1 as SARS-CoV-related CoVs (SARSr-CoVs), L2 SARS-CoV-2-related (SC2r-CoVs) novel L-R (recombinants L1 L2)-present in...
Abstract Sirtuins, which are NAD + -dependent class III histone deacetylases, involved in various biological processes, including DNA damage repair, immune inflammation, oxidative stress, mitochondrial homeostasis, autophagy, and apoptosis. Sirtuins essential regulators of cellular function organismal health. Increasing evidence suggests that the development age-related diseases, kidney is associated with aberrant expression sirtuins, regulation sirtuins activity can effectively improve...
Moyamoya disease (MMD) is a rare cerebral vasculopathy characterized by bilateral internal carotid artery stenosis and often leads to stroke in children or young adults. Although familial inheritance well recognized, the genetic basis of MMD remains poorly understood.A 2-stage genome-wide association study was conducted involving 1492 cases 5084 controls. In discovery stage, logistic regression used test associations, imputation based on genotyped single-nucleotide polymorphisms (SNPs)....
The global incidence of infertility is increasing year by year, and the association between mental illness has been widely concerned. aim this study was to investigate anxiety depression in infertile women China explore risk factors which might lead depression. From January 2020 December 2020, female patients who received assisted reproduction technology (ART) treatment at West Second Hospital were recruited a total 1712 eligible finally enrolled study. Generalized Anxiety Disorder-7 (GAD-7)...
Bats (Order Chiroptera) are an important reservoir of emerging zoonotic microbes, including viruses public health concern such as henipaviruses, lyssaviruses, and SARS-related coronaviruses. Despite the continued discovery new in bat populations, a significant proportion these viral agents remain uncharacterized, highlighting imperative for additional research aimed at elucidating their evolutionary relationship taxonomic classification. In order to delve deeper into hosted by bats, present...
Deep frying in oil is a popular cooking method around the world. However, safety of deep-fried edible oil, which ingested with fried food, concern, because exposed continuously to be re-used at high temperature, leading number well-known chemical reactions. Thus, this study investigates changes energy metabolism, colon histology and gut microbiota rats following consumption explores mechanisms involved above alterations.Deep-fried was prepared published method. Adult male Wistar were...
The role of cellular senescence induced by radiation in bone loss has attracted much attention. As one the common complications anticancer radiotherapy, irradiation-induced deterioration is and clinically significant, but pathological mechanism not been elucidated. This study was performed to explore senescence-associated secretory phenotype (SASP) induction marrow-derived mesenchymal stem cells (BMSCs) irradiation its osteogenic differentiation dysfunction. It observed that irradiated BMSCs...
Abstract Emerging infectious diseases significantly threaten global public health and socioeconomic security. The majority of emerging disease outbreaks are caused by zoonotic/vector-borne viruses. Bats rodents the two most important reservoir hosts many zoonotic viruses that can cross species barriers to infect humans, whereas mosquitos ticks well-established major vectors arboviral diseases. Moreover, some require a vector spread or intrinsically vector-borne zoonotically transmitted. In...
ABSTRACT Aim To identify the barriers and enablers in implementation of evidence‐based physical activity (PA) programmes for improvement health outcomes among pregnant women with gestational diabetes mellitus (GDM), to develop strategies implementing this evidence clinical practice. Methods A convergent mixed‐methods study was conducted, integrating a descriptive qualitative research design cross‐sectional survey. In‐depth interview used collect views cognitions about from medical staff,...
Abstract Rabies, caused by rabies virus, is a severe public health problem in the Philippines, where animal epidemiology had been extensively investigated, but little known about national epidemiologic situations since 2010. Here, we report 12-year nationwide surveillance with systematic phylogenetic analysis, which 353 whole genomes of viruses collected from cases between 2018 and 2022 were obtained. The spatial–temporal evolutionary analyses showed that Philippines exclusively classified...
Abstract Persimmon fruit is highly susceptible to chilling injury (CI) during cold storage. Notably, glycine betaine (GB), a compound that helps regulate cell osmotic balance, can alleviate postharvest CI in various fruits. In this study, the application of GB increased tolerance, delayed CI, and reduced index ‘Youhou’ sweet persimmon Moreover, treatment markedly decreased O 2 − · production rate malondialdehyde (MDA) H content while significantly increasing ascorbic amounts acid glutathione...
Abstract In the wake of pandemics like COVID-19, which have zoonotic origins, role wildlife as reservoirs for emerging infectious diseases has garnered heightened attention. Migratory birds, traversing continents, represent a potent but under-researched vector spread diseases, including novel coronaviruses. This study delves into genetic diversity and transmission dynamics coronaviruses in migratory presenting pivotal findings. From April 2019 to 2023, we screened 5,263 bird samples...
Purpose Rampant misinformation on social media leads to a crisis of public confidence, which can hinder the implementation management measures during crisis. Adapting Theoretical Multidimensional Model Risk Perception (TMMRP) and incorporating Five-Factor (FFM) personality, this study explores how receivers’ risk perception personality traits influence their engagement behaviors health crises. Design/methodology/approach Participants were sampled from Sina Weibo ( N = 1,398), one most...
Rabies is a severe zoonotic disease in China, but the circulation and distribution of rabies virus (RABV) within animal reservoirs not well understood. We report results 15 years surveillance first Chinese Surveillance Plan populations, which brain tissues collected during 2004-2018 were tested for RABV phylogenetic spatial-temporal evolutionary analyses performed using obtained sequences. The have provided most comprehensive dataset to date on infected species, geographic distribution,...
Bats, recognized as considerable reservoirs for coronaviruses (CoVs), serve natural hosts several highly pathogenic CoVs, including SARS-CoV and SARS-CoV-2. Investigating the bat CoV community provides insights into origin CoVs highlights with potential spillover risks. This study probes evolution, recombination, host range, geographical distribution, cross-species transmission characteristics of across China its associated in other regions. Through detailed research on 13,064 samples from...
The fruiting body of Ganoderma lucidum has been used as a traditional herbal medicine for many years. However, to the date, there is no detailed study describing effect G. spores on oxidative stress, blood glucose level and lipid compositions in animal models type 2 diabetic rats, particular gene expression profiles associated with metabolisms.
Melanoma differentiation associated gene 5 (MDA5) and retinoic acid-inducible gene-I (RIG-I) selectively sense cytoplasmic viral RNA to induce an antiviral immune response. Infectious bronchitis virus (IBV) is one of the most important infectious agents in chickens, chicken cells, it can be recognized by MDA5 activate interferon production. RIG-I considered absent chickens. However, absence chickens raises question whether this protein influences response against IBV infection. Here, we...