A5100387926- Finite Group Theory Research
- interferon and immune responses
- COVID-19 epidemiological studies
- graph theory and CDMA systems
- Viral Infections and Vectors
- Respiratory Support and Mechanisms
- Limits and Structures in Graph Theory
- Pneumonia and Respiratory Infections
- Nosocomial Infections in ICU
- Inflammasome and immune disorders
- Corneal Surgery and Treatments
- Catalysis and Oxidation Reactions
- Mental Health via Writing
- Sentiment Analysis and Opinion Mining
- Calcium signaling and nucleotide metabolism
- CRISPR and Genetic Engineering
- Nutrition and Health in Aging
- Developmental Biology and Gene Regulation
- Circadian rhythm and melatonin
- Healthcare Policy and Management
- Rings, Modules, and Algebras
- Gene Regulatory Network Analysis
- Virus-based gene therapy research
- Cardiac, Anesthesia and Surgical Outcomes
- Immune Response and Inflammation
Academy of Military Medical Sciences
2024-2025
Shanxi Medical University
2022-2025
First Hospital of Shanxi Medical University
2022-2025
Institute of Zoology
2022-2024
Chinese Academy of Sciences
2022-2024
École Polytechnique Fédérale de Lausanne
2024
Southeast University
2024
Lurie Children's Hospital
2024
Northwestern University
2024
University of Chinese Academy of Sciences
2022-2024
CRISPR-based gene therapies are making remarkable strides toward the clinic. But large size of most widely used Cas endonucleases including Cas9 and Cas12a restricts their efficient delivery by adeno-associated virus (AAV) for in vivo editing. Being exceptionally small, recently engineered type V-F CRISPR-Cas12f1 systems can overcome cargo packaging bottleneck present as strong candidates therapeutic applications. In this study, pairwise editing efficiencies different Cas12f1/sgRNA scaffold...
Digital technologies are empowering economic and social development, which attracts scholars' attention to the relationship between digitalization resilience, However, empirical analysis for different countries stages of development inconsistent, influencing mechanism need be further explored. Using panel data 284 prefecture-level cities in China from 2007 2020, this study examines impact urban digital on resilience. The findings as follows: (1) increased significantly enhances effect was...
Peripheral immune markers have been associated with the progression and prognosis of amyotrophic lateral sclerosis (ALS). However, whether dysregulation peripheral immunity is a risk factor for ALS or consequence motor neuron degeneration has not yet clarified. We aimed to identify longitudinal associations between prediagnostic incident ALS.A total 345,000 individuals from UK Biobank 2006 2010 were included at baseline. The counts (neutrophils, lymphocytes, monocytes, platelets, CRP) its...
Comorbidities may complicate medical situations and have an impact on the treatment decisions poor survival of cancer patients. How comorbidities cluster together ultimately affect patients' outcomes in gastrointestinal tract (GTC) is a poorly understood area. In multicenter prospective observational study from 2012 to 2021, we grouped patients with GTC by latent class analysis, obtaining two comorbidity classes. Cox regression models were initially used predict mortality. LASSO techniques...
Abstract Rabies, caused by rabies virus, is a severe public health problem in the Philippines, where animal epidemiology had been extensively investigated, but little known about national epidemiologic situations since 2010. Here, we report 12-year nationwide surveillance with systematic phylogenetic analysis, which 353 whole genomes of viruses collected from cases between 2018 and 2022 were obtained. The spatial–temporal evolutionary analyses showed that Philippines exclusively classified...
Ventilator-associated pneumonia (VAP) is a significant and common health concern. The epidemiological landscape of VAP poorly understood in neurosurgery patients. This study aimed to explore the epidemiology this population devise targeted surveillance, treatment, control efforts.
Abstract Background Research on human pluripotent stem cells (hPSCs) has shown tremendous progress in cell-based regenerative medicine. Corneal endothelial dysfunction is associated with the loss and degeneration of corneal (CECs), rendering cell replacement a promising therapeutic strategy. However, comprehensive preclinical assessments hPSC-derived CECs for this therapy remain challenge. Results Here we defined an adapted differentiation protocol to generate induced (iCECs) consistently...
Centromere protein L (CENPL) is associated with a variety of human diseases. However, its function in breast cancer remains uncertain. The Cancer Genome Atlas (TCGA) and genotype-tissue expression across data were used to investigate CENPL expression. Using TCGA clinical survival data, the relationship between patient prognosis was assessed. cluster profiler R software tool, enrichment analysis carried out. Additionally, by studying database, immune cell infiltration To evaluate CENPL's...
ChatGPT has piqued the interest of many fields, particularly in academic community. GPT-4, latest version, starts supporting multimodal input and output. This study examines social media posts to analyze how Chinese public perceives potential for educational general purposes. The also serves as first effort investigate changes opinion since release GPT-4. According analysis results, prior although some users believed that AI advancements would benefit education society, advanced AI, such...
Objective: Drug-resistant tuberculosis (DR-TB) in children seriously threatens TB control. Information on the epidemiology and characteristics of DR-TB China is limited. We studied data Shenyang Tenth People's Hospital to understand Shenyang. Design or Methods: retrospectively analyzed drug resistance testing pediatric patients between 2017 2021, included 2976 clinically-diagnosed patients. described trends incidence. The Kappa value was calculated assess agreement MGIT 960 DST Xpert MTB/RIF...
Midbrain dopaminergic (DA) progenitors derived from human pluripotent stem cells are considered to be a promising treatment for Parkinson's disease (PD). However, the differentiation process produces undesired cell types, which influence in vivo evaluation of DA cells. In this paper, we analyze fate choice during and provide valuable information on preparation. Human embryonic were differentiated into progenitors. We applied single-cell RNA sequencing (scRNA-seq) at different time points...
To evaluate the 24-week interim outcomes of bedaquiline-containing regimens in treatment adolescents with rifampicin-resistant tuberculosis (RR-TB) China.Adolescents RR-TB from two hospitals were included this retrospective study. All patients received longer regimen containing bedaquiline. Sputum culture, chest computed tomography, blood tests and electrocardiography performed regularly, after 24 weeks reported.Four male six female aged 11 to 17 years old included. Among them, four (40.0%),...
Venous thromboembolism is a common complication in patients with colorectal cancer who exhibit high homocysteine and low folate levels. However, whether venous thrombosis the result of direct effect folic acid or presence homocysteine-mediated mediating cannot be determined. This study aimed to explore association effects serum on cancer.This included were admitted First Hospital Shanxi Medical University from May 2020 2022. The patients' medical records reviewed collect information general...
Let $[n]:=\lbrace 1,2,\ldots,n \rbrace$, and $M$ be a set of positive integers. Denote the family all subsets $[n]$ with sizes in by $\binom{\left[n\right]}{M}$. The non-empty families $\mathcal{A}\subseteq\binom{\left[n\right]}{R}$ $\mathcal{B}\subseteq \binom{\left[n\right]}{S}$ are said to cross $t$-intersecting if $|A\cap B|\geq t$ for $A\in \mathcal{A}$ $B\in \mathcal{B}$. In this paper, we determine maximum sum families, characterize extremal families. Similar result finite vector...