A5100453661- Gut microbiota and health
- Fungal Biology and Applications
- Microbial Natural Products and Biosynthesis
- Diet and metabolism studies
- Ginseng Biological Effects and Applications
- Polysaccharides and Plant Cell Walls
- Phytochemistry and Bioactivity Studies
- Nutritional Studies and Diet
- Plant biochemistry and biosynthesis
- Apelin-related biomedical research
- HIV-related health complications and treatments
- Algal biology and biofuel production
- Tryptophan and brain disorders
- Genomics and Phylogenetic Studies
- Dietary Effects on Health
- Hepatitis C virus research
- Traditional Chinese Medicine Analysis
- Clostridium difficile and Clostridium perfringens research
- Natural product bioactivities and synthesis
- Biological Activity of Diterpenoids and Biflavonoids
- Medicinal plant effects and applications
- Vector-borne infectious diseases
- Medicinal Plants and Bioactive Compounds
- Reproductive biology and impacts on aquatic species
- Cholinesterase and Neurodegenerative Diseases
Chinese Academy of Sciences
2012-2025
Center for Excellence in Molecular Plant Sciences
2013-2025
Qinghai University
2022-2025
Shanxi Medical University
2025
Shaanxi Provincial People's Hospital
2025
Kunming Municipal Hospital of Traditional Chinese Medicine
2020-2024
Anhui Medical University
2024
Chengdu University
2022-2024
Institute of Microbiology
2015-2024
Albert Einstein College of Medicine
2019-2024
Tryptophan can be catabolised to various metabolites through host kynurenine and microbial indole pathways. We aimed examine relationships of tryptophan with incident type 2 diabetes (T2D), genetics, diet gut microbiota.
BACKGROUND: Consistent evidence suggests diabetes-protective effects of dietary fiber intake. However, the underlying mechanisms, particularly role gut microbiota and host circulating metabolites, are not fully understood. We aimed to investigate metabolites associated with intake their relationships type 2 diabetes (T2D). METHODS: This study included up 11 394 participants from HCHS/SOL (Hispanic Community Health Study/Study Latinos). Diet was assessed two 24-hour recalls at baseline....
Acid-sensing ion channels (ASICs) are proton-gated cation that involved in diverse neuronal processes including pain sensing. The peptide toxin Mambalgin1 (Mamba1) from black mamba snake venom can reversibly inhibit the conductance of ASICs, causing an analgesic effect. However, detailed mechanism by which Mamba1 inhibits ASIC1s, especially how binding to extracellular domain affects conformational changes transmembrane ASICs remains elusive. Here, we present single-particle cryo-EM...
Alterations in gut microbiota and blood metabolomic profiles have been implicated HIV infection cardiovascular disease. However, it remains unclear whether alterations may contribute to disrupted host relation atherosclerosis, especially the context of infection. We analyzed cross-sectional associations between features carotid artery plaque 361 women with or at high risk (67% HIV+), further integrated plaque-associated microbial plasma lipidomic/metabolomic profiles. Furthermore, 737 men,...
Abstract Background Alterations in gut microbiota have been implicated HIV infection and cardiovascular disease. However, how microbial alterations relate to host inflammation metabolite profiles, their relationships with atherosclerosis, not well-studied, especially the context of infection. Here, we examined associations species functional components measured by shotgun metagenomics carotid artery plaque assessed B-mode ultrasound 320 women or at high risk (65% +) from Women’s Interagency...
The Microbiome Protocols eBook (MPB) serves as a crucial bridge, filling gaps in microbiome protocols for both wet experiments and data analysis. first edition, launched 2020, featured 152 meticulously curated protocols, garnering widespread acclaim. We now extend sincere invitation to researchers participate the upcoming 2nd version of MPB, contributing their valuable advance research. is research area that focuses on studying omics microbe [1] with rapid development past few decades,...
Streptomyces coelicolor, with its 8 667 507-bp linear chromosome, is the genetically most studied species and an excellent model for studying antibiotic production cell differentiation. Here, we report construction of S. coelicolor derivatives containing sequential deletions all 10 polyketide synthase (PKS) nonribosomal peptide synthetase (NRPS) biosynthetic gene clusters a 900-kb subtelomeric sequence (total c. 1.22 Mb, 14% genome). No obvious differences in growth rates sporulation strains...
In addition to binding intracellular fatty acids, fatty-acid-binding proteins (FABPs) have recently been reported also transport the endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol (2-AG), arachidonic acid derivatives that function as neurotransmitters mediate a diverse set of physiological psychological processes. To understand how bind FABPs, crystal structures FABP5 in complex with AEA, 2-AG inhibitor BMS-309403 were determined. These ligands are shown interact primarily...
Lipid A is an essential basal component of lipopolysaccharide most Gram-negative bacteria. Inhibitors targeting LpxC, a conserved enzyme in lipid biosynthesis, are antibiotic candidates against pathogens. Here we report the characterization role Coxiella burnetii growth axenic media, monkey kidney cells (BGMK and Vero) macrophage-like THP-1 by using potent LpxC inhibitor -LPC-011. We first determined susceptibility C. to LPC-011 surrogate E. coli model. In coli, minimum inhibitory...
Alterations in gut microbiota (GMB) and host metabolites have been noted individuals with HIV. However, it remains unclear whether alterations GMB related functional groups contribute to disrupted metabolite profiles these individuals.
Obesity and related comorbidities are major health concerns among many US immigrant populations. Emerging evidence suggests a potential involvement of the gut microbiome. Here, we evaluated microbiome features their associations with immigration, dietary intake, obesity in 2640 individuals from population-based study Hispanics/Latinos.The fecal shotgun metagenomics data indicate that greater exposure is associated reduced ɑ-diversity, functions fiber degradation, alterations individual taxa,...
Introduction Cordyceps sinensis is a fungus, serves dual purposes as both medicinal herb and food source. Due to its high water content, fresh difficult preserve, necessitating the drying necessary process . Methods Using 4D-DIA proteomics, researchers analyzed proteome profiles of (CK) under three different conditions: vacuum freeze-drying (FD), oven-drying (OD), air-drying (AD). In addition, it was found that protein free sulfhydryl content decreased significantly disulfide bond increased...
The 80% aqueous acetone extract from the whole plant of Saussurea medusa MAXIM. was found to inhibit rat lens aldose reductase (IC50=1.4 μg/ml). From this extract, flavonoids, lignans, and quinic acid derivatives were isolated together with two new ionone glycosides, saussureosides A B. Their absolute stereostructures elucidated on basis chemical physicochemical evidence including application modified Mosher's method. In addition, some isolates show an inhibitory effect reductase.