A5017794844- Diet and metabolism studies
- HIV-related health complications and treatments
- Gut microbiota and health
- Nutritional Studies and Diet
- Cardiovascular Function and Risk Factors
- Food Security and Health in Diverse Populations
- Liver Disease Diagnosis and Treatment
- Pharmaceutical and Antibiotic Environmental Impacts
- Hepatitis C virus research
- Antibiotic Use and Resistance
- Probiotics and Fermented Foods
- Peripheral Artery Disease Management
- Diet, Metabolism, and Disease
- Fecal contamination and water quality
- Cardiovascular Health and Risk Factors
- Antibiotic Resistance in Bacteria
- Genetic Associations and Epidemiology
- HIV/AIDS Research and Interventions
- Metabolomics and Mass Spectrometry Studies
- HIV Research and Treatment
- Diagnosis and Treatment of Venous Diseases
- Wastewater Treatment and Reuse
- Digestive system and related health
- Toxoplasma gondii Research Studies
- RNA modifications and cancer
Washington State University
2023-2024
Fred Hutch Cancer Center
2019-2023
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
2023
University of Washington
2014-2021
Washington Center
2019
Harborview Medical Center
2019
University of Minnesota
2013-2017
Seattle University
2017
We propose a simple causal model depicting relationships involved in dissemination of antibiotics and antibiotic resistance agroecosystems potential effects on human health, functioning natural ecosystems, agricultural productivity. Available evidence for each link is briefly summarized, key knowledge gaps are highlighted. A lack quantitative estimates exposure to environmental bacteria, general, antibiotic-resistant specifically, significant data gap hindering the assessment health. The...
Abstract Background Hispanics living in the USA may have unrecognized potential birthplace and lifestyle influences on gut microbiome. We report a cross-sectional analysis of 1674 participants from four centers Hispanic Community Health Study/Study Latinos (HCHS/SOL), aged 18 to 74 years old at recruitment. Results Amplicon sequencing 16S rRNA gene V4 fungal ITS1 fragments self-collected stool samples indicate that host microbiome is determined by sociodemographic migration-related...
Alterations in gut microbiota (GMB) and host metabolites have been noted individuals with HIV. However, it remains unclear whether alterations GMB related functional groups contribute to disrupted metabolite profiles these individuals.
Obesity and related comorbidities are major health concerns among many US immigrant populations. Emerging evidence suggests a potential involvement of the gut microbiome. Here, we evaluated microbiome features their associations with immigration, dietary intake, obesity in 2640 individuals from population-based study Hispanics/Latinos.The fecal shotgun metagenomics data indicate that greater exposure is associated reduced ɑ-diversity, functions fiber degradation, alterations individual taxa,...
Hypertension has been implicated as a smoking-related risk factor for cardiovascular disease but the dose-response relationship is incompletely described. Hispanics, who often have relatively light smoking exposures, understudied in this regard.We used data from 6-year follow-up study of US Hispanic adults aged 18-76 to address linking cigarette use with incident hypertension, which was defined by measured blood pressure above 140/90 mm Hg or initiation antihypertensive medications....
Direct-acting antiviral (DAA) therapy have been shown to be highly successful in clinical trials and observational studies, but less is known about treatment success patients with a high burden of comorbid conditions, including mental health substance use disorders. We evaluated DAA effectiveness across broad spectrum human immunodeficiency virus (HIV)–hepatitis C (HCV) coinfection routine care, those psychosocial conditions. The primary end point was sustained virologic response (SVR),...
Advances in antiretroviral therapies have greatly improved the survival of people living with human immunodeficiency virus (HIV) infection (PLWH); yet, PLWH a higher risk cardiovascular disease than those without HIV. While numerous genetic loci been linked to cardiometabolic general population, predictors excessive are largely unknown.We screened for common and HIV-specific variants associated variation lipid levels 6284 (3095 European Americans [EA] 3189 African [AA]), from Centers AIDS...
Non-alcoholic fatty liver disease (NAFLD) has been associated with increased risk of incident diabetes. But such evidence is lacking in the Hispanic/Latino population, which high prevalence obesity and NAFLD.We conducted a prospective cohort study 6,928 adults background who had no diabetes, did not report excessive alcohol use, hepatitis B C infection at baseline (2008-2011). We estimated ratios (RR) for identified from visit 2 examination by glucose measurements or antidiabetic medication...
People living with HIV are at risk of increased myocardial infarction (MI). Cumulative viral load (VL) has been proposed as a better measure inflammation than other measures VL, like baseline but its associations MI not known.The multisite Centers for AIDS Research Network Integrated Clinical Systems (CNICS) cohort includes clinical data and centrally adjudicated distinction between atheroembolic (type 1) related to supply-demand mismatch 2). We examined CNICS participants who were on...
Abstract Background Understanding human genetic influences on the gut microbiota helps elucidate mechanisms by which genetics may influence health outcomes. Typical microbiome genome-wide association studies (GWAS) marginally assess between individual variants and microbial taxa. We propose a novel approach, covariate-adjusted kernel RV (KRV) framework, to map associated with beta-diversity, focuses overall shifts in microbiota. The KRV framework evaluates microbes comparing similarity...
We sought to evaluate the acceptability and feasibility of a culturally tailored food box intervention for improving blood pressure (BP), security Body Mass Index (BMI) among Chickasaw Nation adults with uncontrolled hypertension. As part Healthy Eating Environments Research Study (CHEERS), we administered group randomized pilot study in four tribal communities (two intervention, two control). Participants received six heart-healthy boxes, traditional diet current context. Outcomes were...
Toxoplasmosis is among the most widespread and prevalent zoonosis in world. People can become infected through ingestion of oocysts shed by felids or tissue cysts contained meat from animals. Acute infection result a wide spectrum consequences, including flu-like illness retinitis, as well congenital pregnant women. Severe disease occur, especially if people are immunocompromised. Frequency human varies substantially region due to ecological, social, cultural factors. The recent nationwide...
Hepatitis C virus (HCV) infection is common among people living with human immunodeficiency (PLWH). Extrahepatic manifestations of HCV, including myocardial infarction (MI), are a topic active research. MI classified into types, predominantly atheroembolic type 1 (T1MI) and supply-demand mismatch 2 (T2MI). We examined the association between HCV patients in Centers for AIDS Research (CFAR) Network Integrated Clinical Systems, US multicenter clinical cohort PLWH. MIs were centrally...
Abstract Metabolic dysregulation and alterations have been linked to various diseases conditions. Innovations in high-throughput technology now allow rapid profiling of the metabolome metagenome — often gene content bacterial populations -– for characterizing metabolism. Due small sample sizes high dimensionality data, pathway analysis (wherein effect multiple genes or metabolites on an outcome is cumulatively assessed) metabolomic data commonly conducted also represents a standard...
Steatotic liver disease (SLD) is the most common chronic strongly associated with metabolic dysfunction, but its pathogenesis remains incompletely understood. Exploring plasma circulating metabolites may help in elucidating underlying mechanisms and identifying new biomarkers for SLD. We examined cross-sectionally association between SLD as well enzymes using data from 4 population-based cohort studies (Rotterdam study, Avon Longitudinal Study of Parents Children, The Insulin Resistance...