A5101799491- Chronic Kidney Disease and Diabetes
- Blood Pressure and Hypertension Studies
- Dialysis and Renal Disease Management
- Cardiovascular Health and Disease Prevention
- Renal and Vascular Pathologies
- Cardiovascular Health and Risk Factors
- Cardiovascular Function and Risk Factors
- Heart Rate Variability and Autonomic Control
- Renal Diseases and Glomerulopathies
- Nutritional Studies and Diet
- Birth, Development, and Health
- Health Systems, Economic Evaluations, Quality of Life
- Sodium Intake and Health
- Parathyroid Disorders and Treatments
- Dementia and Cognitive Impairment Research
- Acute Kidney Injury Research
- Chronic Disease Management Strategies
- Diabetes Treatment and Management
- Heart Failure Treatment and Management
- HIV-related health complications and treatments
- Cerebrovascular and Carotid Artery Diseases
- Hemoglobinopathies and Related Disorders
- Folate and B Vitamins Research
- Potassium and Related Disorders
- Pharmaceutical Practices and Patient Outcomes
San Francisco VA Medical Center
2015-2024
University of California, San Francisco
2015-2024
San Francisco VA Health Care System
2020-2022
Stanford University
2007-2021
Kyoto University
2021
Tufts Medical Center
2021
Clinical Research Consortium
2021
Lenox Hill Hospital
2021
University of Colorado Anschutz Medical Campus
2021
Novartis (Switzerland)
2020
A triple-marker approach for chronic kidney disease (CKD) evaluation has not been well studied.To evaluate whether combining creatinine, cystatin C, and urine albumin-to-creatinine ratio (ACR) would improve identification of risks associated with CKD compared creatinine alone.Prospective cohort study involving 26,643 US adults enrolled in the Reasons Geographic Racial Differences Stroke (REGARDS) from January 2003 to June 2010. Participants were categorized into 8 groups defined by estimated...
Background-The association of hypertension and mortality is attenuated in elderly adults.Walking speed, as a measure frailty, may identify which elders are most at risk for the adverse effects hypertension.We hypothesized that elevated blood pressure (BP) would be associated with greater faster, but not slower, walking older adults. Methods-Participants included 2,340 persons ≥65 years National Health NutritionExamination Survey, 1999-2000 2001-2002.Mortality data was linked to death...
Importance Novel therapies for type 2 diabetes can reduce the risk of cardiovascular disease and chronic kidney progression. The equitability these agents’ prescription across racial ethnic groups has not been well-evaluated. Objective To investigate differences in sodium-glucose cotransporter-2 inhibitors (SGLT2i) glucagon-like peptide-1 receptor agonists (GLP-1 RA) among adult patients with by groups. Design, Setting, Participants Cross-sectional analysis data from US Veterans Health...
Although cystatin C is a stronger predictor of clinical outcomes associated with CKD than creatinine, the role for unclear. We included 11,909 participants from Multi-Ethnic Study Atherosclerosis (MESA) and Cardiovascular Health (CHS) assessed risks death, cardiovascular events, heart failure, ESRD among persons categorized into mutually exclusive groups on basis biomarkers that supported diagnosis (eGFR <60 ml/min per 1.73 m(2)): creatinine only, both, or neither. used CKD-EPI equations to...
Although improved control of hypertension is known to attenuate progression chronic kidney disease (CKD), little about the adequacy treatment in adults with CKD United States. Using data from Fourth National Health and Nutrition Survey, we assessed adherence national guideline targets for patients (blood pressure <130/80 mm Hg), systolic (<130 Hg) diastolic (<80 blood pressure, evaluated determinants adequate control. Presence was defined as glomerular filtration rate <60 mL/min...
Background and objectives: Higher phosphorus levels are associated with cardiovascular disease (CVD) events mortality. Whether vascular stiffness may be responsible is unknown. Design, setting, participants, & measurements: This study examined the cross-sectional associations of serum ankle brachial index (ABI), pulse pressure, large small artery elasticity by radial waveform analysis among 1370 individuals (440 moderate chronic kidney disease) who did not have clinical CVD participated...
Whether the rate of kidney function decline before onset CKD differs among racial and ethnic groups remains unclear. Here, we evaluated incident white, black, Hispanic, Chinese participants in Multi-Ethnic Study Atherosclerosis (MESA) during 5 years follow-up. We estimated GFR using both cystatin C (eGFRcys) creatinine (eGFRcreat). The definition required eGFRcys <60 ml/min per 1.73 m(2) a ≥1 year. Among with eGFRcreat >60 at baseline, blacks had significantly higher than whites (0.31...
Variants in the APOL1 gene are associated with kidney disease blacks. We examined associations of incident albuminuria and function decline among 3030 young adults preserved GFR Coronary Artery Risk Development Young Adults (CARDIA) study. eGFR by cystatin C (eGFRcys) albumin-to-creatinine ratio were measured at scheduled examinations. Participants white (n=1700), high-risk black (two risk alleles, n=176), low-risk (zero/one allele, n=1154). Mean age was 35 years, mean eGFRcys 107 ml/min per...
Background: Treatment of hypertension is difficult in chronic kidney disease (CKD), and blood pressure goals remain controversial.The association between each component end-stage renal (ESRD) risk less well known. Methods:We studied associations systolic diastolic (SBP DBP, respectively) pulse (PP) with ESRD among 16 129 Kidney Early Evaluation Program (KEEP) participants an estimated glomerular filtration rate 60 mL/min/ 1.73 m 2 using Cox proportional hazards.We the prevalence...
Whether inclusion of the coronary artery calcium score improves cardiovascular risk prediction in individuals with CKD, a population unique calcium-phosphate homeostasis, is unknown. Among 6553 participants ages 45-84 years without prior disease Multi-Ethnic Study Atherosclerosis, was assessed for beyond Framingham predictors those (n=1284) and CKD contrasted carotid intima-media thickness ankle-brachial index (two other measures subclinical atherosclerosis). During median follow-up 8.4...
Previous studies in HIV-infected individuals have demonstrated serum albumin to be strongly associated with kidney function decline, independent of urine and inflammatory markers. Lower concentrations may an under-appreciated risk factor for decline elders. We performed a cohort analysis the Health Aging Body Composition Study, well-functioning, bi-racial, community-dwelling elders between age 70 79 years. examined associations concentration longitudinal by estimated glomerular filtration...
CKD is associated with mortality. Accurate prediction tools for mortality may guide clinical decision-making, particularly among elderly persons CKD.A equation was developed 5-year risk of participants in the Cardiovascular Health Study. Sixteen candidate predictor variables were explored, which included demographics, physical examination measures, comorbidity, medication use, and kidney function measures (eGFR calculated from serum creatinine Epidemiology Collaboration urine...
Background and objectives Although anthropometric measures of body fat are associated with development CKD, they may not be able to distinguish between various forms therefore less accurate than computed tomography (CT) measures. We compared the association CT obesity kidney outcomes in Health Aging Body Composition Study. Design, setting, participants, & measurements Participants were recruited from March 1997 through July 1998. included visceral abdominal (VAT), subcutaneous adipose...
Rates of ESRD are rising faster in Hispanic than non-Hispanic white individuals, but reasons for this unclear. Whether rates cardiovascular events and mortality differ among patients with chronic kidney disease (CKD) also is not well understood. Therefore, study examined the associations between ethnicity risks ESRD, events, death CKD. A total 39,550 stages 3 to 4 CKD from Kaiser Permanente Northern California were included. was obtained self-report supplemented by surname matching. GFR...
Background: Kidney disease and hypertension commonly coexist, yet the direction of their association is still debated. Objective: To evaluate whether early kidney dysfunction, measured by serum cystatin C levels urinary albumin excretion, predates in adults without clinically recognized or cardiovascular disease. Design: Observational cohort study using data from 2000 to 2005. Setting: The MESA (Multi-Ethnic Study Atherosclerosis), a community-based subclinical age 45 84 years. Participants:...