A5022346670- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Blood Pressure and Hypertension Studies
- Parathyroid Disorders and Treatments
- Vitamin D Research Studies
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiovascular Health and Disease Prevention
- Renal and Vascular Pathologies
- Liver Disease Diagnosis and Treatment
- Acute Kidney Injury Research
- Cardiovascular Disease and Adiposity
- Folate and B Vitamins Research
- Renal Diseases and Glomerulopathies
- Bone health and osteoporosis research
- Cancer Genomics and Diagnostics
- Fibroblast Growth Factor Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Aortic Thrombus and Embolism
- Cardiac Valve Diseases and Treatments
- Nutrition and Health in Aging
- Heart Failure Treatment and Management
- Health Systems, Economic Evaluations, Quality of Life
- Ovarian cancer diagnosis and treatment
- Renal function and acid-base balance
University of Washington
2016-2025
Seattle University
2007-2024
Weatherford College
2024
Fred Hutch Cancer Center
2024
Community Link
2023
St. Vincent Hospital
2021
Children's Hospital of Wisconsin
2018-2020
Medical College of Wisconsin
2020
Kidney Research UK
2014-2019
The Lundquist Institute
2009-2017
Cystatin C is a serum measure of renal function that appears to be independent age, sex, and lean muscle mass. We compared creatinine cystatin levels as predictors mortality from cardiovascular causes all in the Cardiovascular Health Study, cohort study elderly persons living community.
Background: Cystatin C is an alternative measure of kidney function that may have prognostic importance among elderly persons who do not meet standard criteria for chronic disease (estimated glomerular filtration rate [GFR] ≥60 mL/min per 1.73 m2). Objective: To evaluate cystatin as a biomarker death, cardiovascular disease, and incident without disease. Design: Cohort study. Setting: The Cardiovascular Health Study, population-based cohort recruited from 4 communities in the United States....
Anemia is viewed as a negative prognostic factor in the elderly population; its independent impact on survival unclear.Baseline hemoglobin quintiles and anemia, defined by World Health Organization criteria, were assessed relation to mortality Cardiovascular Study, prospective cohort study with 11.2 years of follow-up 5888 community-dwelling men women 65 or older, enrolled 1989-1990 1992-1993 4 US communities.A total 1205 participants lowest quintile (<13.7 g/dL for men; <12.6 women), 498...
Impaired kidney function is associated with increased mortality risk in older adults. It remains unknown, however, whether longitudinal declines are independently cardiovascular and all-cause adults.The Cardiovascular Health Study evaluated a cohort of community-dwelling adults enrolled from 1989 to 1993 4 US communities follow-up through 2005. Among 4380 participants, the slope annual decline estimated glomerular filtration rate (eGFR) was using both serum creatinine (eGFR(creat)) cystatin...
Chronic kidney disease (CKD), defined at a specific time point, is an important risk factor for cardiovascular disease. Whether the rate of function decline contributes additional unknown. In Cardiovascular Health Study, we compared associations changes in during first 7 yr with incidence heart failure (HF), myocardial infarction (MI), stroke, and peripheral arterial (PAD) subsequent 8 yr. We rapid cystatin C–based estimated GFR as >3 ml/min per 1.73 m2/yr, on basis determination baseline,...
Tree-based machine learning models such as random forests, decision trees, and gradient boosted trees are the most popular non-linear predictive used in practice today, yet comparatively little attention has been paid to explaining their predictions. Here we significantly improve interpretability of tree-based through three main contributions: 1) The first polynomial time algorithm compute optimal explanations based on game theory. 2) A new type explanation that directly measures local...
Background: Previous studies that evaluated the association of kidney function with incident heart failure may be limited by insensitivity serum creatinine concentration for detecting abnormal function. Objective: To compare concentrations cystatin C (a novel marker function) and as predictors failure. Design: Observational study based on measurement from frozen sera obtained at 1992–1993 visit Cardiovascular Health Study. Follow-up occurred every 6 months. Setting: Adults 65 years age or...
Chronic kidney disease is associated with a higher risk for cardiovascular mortality, as well all-cause mortality. Whether chronic predictor of noncardiovascular mortality less clear. To further explore the latter, association function total and cause-specific was assessed in Cardiovascular Health Study, community-based cohort older individuals. Kidney using cystatin C estimated GFR 4637 participants 1992 to 1993. Participants were followed until June 30, 2001. Deaths adjudicated or by...
A low ankle-arm index (AAI) is a strong predictor of mortality and cardiovascular events. high AAI also appears to be associated with higher risk in select populations. However, across the spectrum have not been described more broadly defined population.We examined total events among 5748 participants Cardiovascular Health Study (CHS). The mean age sample population was 73+/-6 years, included 3289 women (57%) 883 blacks (15%). median duration follow-up 11.1 (0.1 12) years for 9.6 12.1) There...
Background— Calcific aortic valve disease is common in the elderly, correlated with cardiovascular risk factors, and associated increased event risk; however, whether metabolic syndrome an prevalence of calcium (AVC) not known. Methods Results— The AVC, as assessed by computed tomography, was compared 6780 Multi-Ethnic Study Atherosclerosis (MESA) participants (n=1550; National Cholesterol Education Program’s Adult Treatment Panel III [ATP III] criteria), diabetes mellitus (n=1016), or...
To determine whether, in well-functioning older adults, a lower score on the Digit Symbol Substitution Test (DSST) and slower gait are associated with greater risk of mortality developing incident disability independent other factors, including brain structural abnormalities (white matter hyperintensities, infarcts, ventricular enlargement) whether combination varying levels DSST speed than low or slow alone.
Magnesium, potassium, and sodium, cations commonly measured in serum, are involved many physiological processes including energy metabolism, nerve muscle function, signal transduction, fluid blood pressure regulation. To evaluate the contribution of common genetic variation to normal physiologic serum concentrations these cations, we conducted genome-wide association studies magnesium, sodium using ∼2.5 million genotyped imputed single nucleotide polymorphisms (SNPs) 15,366 participants...
Among older adults with chronic kidney disease (CKD), the comparative event rates of end-stage renal (ESRD) and cause-specific death are unknown.To compare ESRD, cardiovascular non-cardiovascular examine risk factors for ESRD all-cause mortality in Cardiovascular Health Study (CHS) participants.The CHS is a longitudinal cohort study community-dwelling aged 65 years older.1,268 participants an estimated glomerular filtration rate (eGFR) < 60 ml/min per 1.73 m(2) were followed until time first...
Although cystatin C is a stronger predictor of clinical outcomes associated with CKD than creatinine, the role for unclear. We included 11,909 participants from Multi-Ethnic Study Atherosclerosis (MESA) and Cardiovascular Health (CHS) assessed risks death, cardiovascular events, heart failure, ESRD among persons categorized into mutually exclusive groups on basis biomarkers that supported diagnosis (eGFR <60 ml/min per 1.73 m(2)): creatinine only, both, or neither. used CKD-EPI equations to...