A5100359213- Fungal Biology and Applications
- Plant and animal studies
- Mycorrhizal Fungi and Plant Interactions
- Biological and pharmacological studies of plants
- Plant Parasitism and Resistance
- Plant Pathogens and Fungal Diseases
- Microbial Natural Products and Biosynthesis
- Berberine and alkaloids research
- Plant tissue culture and regeneration
- Food Quality and Safety Studies
- Pelvic floor disorders treatments
- Alkaloids: synthesis and pharmacology
- Plant and Fungal Species Descriptions
- Anorectal Disease Treatments and Outcomes
- Plant biochemistry and biosynthesis
- Gut microbiota and health
- Wheat and Barley Genetics and Pathology
- Pelvic and Acetabular Injuries
- Tea Polyphenols and Effects
- Agriculture, Soil, Plant Science
- Acute Myeloid Leukemia Research
- Chemical synthesis and alkaloids
- Microbial Metabolites in Food Biotechnology
- Phytochemistry and Bioactivity Studies
- Plant-Microbe Interactions and Immunity
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2025
Soochow University
2023-2025
China Agricultural University
2007-2025
Wenzhou Medical University
2023-2024
First Affiliated Hospital of Soochow University
2023-2024
Weifang Medical University
2024
Xi'an Jiaotong University
2024
Hunan Academy of Traditional Chinese Medicine
2024
Jinan City People's Hospital
2024
Shandong First Medical University
2024
Tuberaceae is one of the most diverse lineages symbiotic truffle-forming fungi. To understand molecular underpinning ectomycorrhizal truffle lifestyle, we compared genomes Piedmont white (Tuber magnatum), Périgord black melanosporum), Burgundy aestivum), pig (Choiromyces venosus) and desert (Terfezia boudieri) to saprotrophic Pezizomycetes. Reconstructed gene duplication/loss histories along a time-calibrated phylogeny Ascomycetes revealed that Tuberaceae-specific traits may be related...
Anterior vaginal prolapse (AVP) is the most common form of pelvic organ (POP) and has deleterious effects on women's health. Despite recent advances in AVP diagnosis treatment, a cell atlas wall not been constructed. Here, we employ single-cell RNA-seq to construct transcriptomic 81,026 individual cells from control samples identify 11 types. We reveal aberrant gene expression diverse types AVP. Extracellular matrix (ECM) dysregulation immune reactions involvement are identified both...
Aim: The usefulness of the white blood cell (WBC) count and neutrophil-to-lymphocyte ratio (NLR) in predicting severity stable coronary artery disease (CAD) has not been sufficiently evaluated, particularly based on strict assessments. aim present study was to investigate WBC NLR angiographically proven CAD.Methods: A total 2,976 CAD patients 571 non-CAD were consecutively enrolled, classified into three groups according tertile Gensini score (GS, low GS<18, n=989; intermediate GS 18-41,...
Dendrobium spp. are traditional Chinese medicinal plants, and the main effective ingredients (polysaccharides alkaloids) have pharmacologic effects on gastritis infection, cancer, anti-aging. Previously, we confirmed endophytic xylariaceous fungi as dominant in several species of tropical regions from China. In present study, diversity, taxonomy, distribution culturable associated with seven (Orchidaceae) were investigated. Among 961 endophytes newly isolated, 217 (morphotaxa) identified...
Jasmonates (JAs) regulate a wide range of plant defense and development processes. The bioactive JA is perceived by its receptor COI1 to trigger the degradation JASMONATE ZIM-DOMAIN (JAZ) proteins subsequently derepress JAZ-repressed transcription factors for activation expression JA-responsive genes. So far, (+)-7-iso-JA-l-Ile has been only identified endogenous molecule. Here, we designed coronafacic acid (CFA) conjugates with all amino acids (CFA-AA) mimic conjugates, revealed that...
Abstract Diterpene cyclases from bacteria and basidiomycete fungi are seldom studied. Here, we presented the identification verification of EriG, a member UbiA superfamily, as enzyme responsible for cyclization cyathane skeleton in mushroom Hericium erinaceum . Genome mining using EriG protein sequence probe led to discovery new family ubiquitous UbiA‐related diterpene fungi. We successfully characterized seven or with help an engineered Escherichia coli strain determined structures their...
Axonopathy is closely linked to the development of diabetic encephalopathy induced by type II diabetes (T2D). Berberine has been shown cross blood-brain barrier and holds promising effect for neuronal damage in diabetes. The present study investigated protective underlying mechanism berberine on axonopathy both vitro vivo models. High glucose/high fat diet streptozotocin injection-induced T2D rat model was used. administered p.o. 10 weeks. Morris water maze test, tracing,...
Mycorrhizal fungi colonize orchid seeds and induce germination. This so-called symbiotic germination is a critical developmental process in the lifecycle of all species. However, molecular changes that occur during seed remain largely unknown. To better understand mechanism germination, we performed comparative transcriptomic proteomic analysis Chinese traditional medicinal Dendrobium officinale to explore change protein expression at different stages asymbiotic identify key proteins...
The polysaccharides isolated from the fruit body of <italic>S. aspratus</italic> (SATPs) might be a potential health supplement or prebiotic in prevention obesity and associated metabolic disorders.
The Microbiome Protocols eBook (MPB) serves as a crucial bridge, filling gaps in microbiome protocols for both wet experiments and data analysis. first edition, launched 2020, featured 152 meticulously curated protocols, garnering widespread acclaim. We now extend sincere invitation to researchers participate the upcoming 2nd version of MPB, contributing their valuable advance research. is research area that focuses on studying omics microbe [1] with rapid development past few decades,...
Probiotics have garnered increasing attention as a potential therapeutic approach for type 2 diabetes mellitus (T2DM). Previous studies confirmed that Bifidobacterium animalis subsp. lactis MN-Gup (MN-Gup) could stimulate the secretion of glucagon-like peptide-1 (GLP-1) in NCI-H716 cells, but whether has hypoglycemic effect on T2DM vivo remains unclear. In this study, mouse model was constructed, with high-fat diet and streptozotocin mice, to investigate diabetes. Then, different doses (2 ×...
The lion's mane mushroom Hericium erinaceus is a famous traditional medicinal fungus credited with anti-dementia activity and producer of cyathane diterpenoid natural products (erinacines) useful against nervous system diseases. To date, few studies have explored the biosynthesis these compounds, although their chemical synthesis known. Here, we report first genome tanscriptome sequence H. erinaceus. size 39.35 Mb, containing 9895 gene models. reveals diverse enzymes large family cytochrome...
Anoectochilus roxburghii (Wall.) Lindl. (Orchidaceae) is an endangered medicinal plant in China, also called “King Medicine”. Due to lacking of sufficient nutrients dust-like seeds, orchid species depend on mycorrhizal fungi for seed germination the wild. As part a conservation plan species, research necessary. However, molecular mechanism and underlying orchid-fungus interactions during symbiotic are poorly understood. In this study, Illumina HiSeq 4000 transcriptome sequencing was...
We retrospectively compared the outcomes of 387 consecutive patients with acquired aplastic anemia (AA) who underwent hematopoietic stem cell transplantation (HSCT) a fludarabine-based conditioning regimen from matched sibling donors (MSD) (n = 108) or haploidentical (HID) 91) and immunosuppressive therapy (IST) 188) 2014 to 2020 at our hospital. Compared HID-HSCT, MSD-HSCT had lower incidence graft failure (1% vs. 7%, p 0.062), grade II–IV acute versus host disease (aGvHD) (16% 35%, 0.001),...
Teratozoospermia is usually associated with defective spermiogenesis and a disorder considerable genetic heterogeneity. Although previous studies have identified several teratozoospermia-associated genes, the etiology remains unknown for majority of affected men. Here, we homozygous missense mutation compound heterozygous CCIN in patients suffering from teratozoospermia. encodes cytoskeletal protein Calicin that involved formation maintenance highly regular organization calyx mammalian...
Synbiotics have revealed the possibility of improving constipation through gut microbiota. The synergistic efficacy Bifidobacterium animalis subsp. lactis BL-99 (BL-99) and fructooligosaccharide (FOS) on not been investigated. Loperamide-induced constipated mice model was established to explore effect BL-99, FOS, BL-99+FOS changes defecation-related parameters, microbiota metabolites. results showed that each alleviated constipation, with synbiotic showing significant in first black stool...