A5100360273- Gut microbiota and health
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Diet and metabolism studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Probiotics and Fermented Foods
- Inflammatory Bowel Disease
- Schizophrenia research and treatment
- Gastrointestinal motility and disorders
- Neuroendocrine regulation and behavior
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects of Natural Compounds
- Mycobacterium research and diagnosis
- Neurotransmitter Receptor Influence on Behavior
- Circadian rhythm and melatonin
- Folate and B Vitamins Research
- Microbial Metabolites in Food Biotechnology
- Photoreceptor and optogenetics research
- Alzheimer's disease research and treatments
- Obsessive-Compulsive Spectrum Disorders
- Dietary Effects on Health
- Ginseng Biological Effects and Applications
- Digestive system and related health
- Regulation of Appetite and Obesity
- Mesenchymal stem cell research
Ministry of Agriculture and Rural Affairs
2022-2025
China Agricultural University
2022-2025
Peking University
2003-2025
Henan Agricultural University
2024-2025
Shanghai Changning Mental Health Center
2025
East China Normal University
2025
Sichuan University
2024
West China Hospital of Sichuan University
2024
Jiangnan University
2024
Jiangxi Mental Health Center
2022-2024
The microbiota–gut–brain axis plays a critical role in the pathogenesis of major depressive disorder (MDD) and related subclinical symptoms. However, studies on gut microbiota MDD are inconsistent, data MDD's effects sleep lacking. This study aimed to analyze composition quality patients with MDD. We performed 16S rRNA sequencing stool samples from 36 45 healthy controls (HC). Sleep was assessed using Pittsburgh Quality Index, severity Hamilton Depression Scale, insomnia Insomnia Severity...
Probiotics could improve cognitive functions in patients with neurological disorders such as Alzheimer’s disease, but the effects on function healthy older adults without impairment need further study. The purpose of this study was to investigate effect Bifidobacterium longum BB68S (BB68S) among impairment. A randomized, double-blind, placebo-controlled trial conducted 60 who were divided into probiotic or placebo groups and required consume either a sachet (BB68S, 5 × 1010 CFU/sachet) once...
Despite the encouraging efficacy of anti-PD-1/PD-L1 immunotherapy in microsatellite-instability-high/deficient mismatch repair (MSI-H/dMMR) advanced gastrointestinal cancer, many patients exhibit primary or acquired resistance. Using multi-omics approaches, we interrogate gut microbiome, blood metabolome, and cytokines/chemokines with MSI-H/dMMR cancer (N = 77) at baseline during treatment. We identify a number microbes (e.g., Porphyromonadaceae) metabolites arginine) highly associated...
Bifidobacterium animalis subsp. lactis A6 ameliorated hippocampal damage and memory impairments in an ADHD rat model by reshaping the gut microbiota composition, alleviating neuron loss inflammation, regulating neurotransmitter release.
Alcohol abuse is a major public health crisis. Relative evidences supported that the gut microbiota (GM) played an important role in central nervous system (CNS) function, and composition of them had changed after alcohol drinking. We sought to explore function GM dependence. In our study, mice with administration was detected through analyzed 16S rRNA gene sequencing fecal metabolites were by LC-MS. The microbial diversity significantly higher group, abundance phylum Firmicutes its class...
Abstract Objective This research examines the intestinal‐associated flora of patients with depression compared healthy volunteers to identify characteristics and differences associated depression. It provides a theoretical basis for prevention treatment through intestinal micro‐ecological regulation. Methods We recruited 30 participate in patient group (PG), were control (HG) from Beijing Hui‐long‐guan Hospital. Thereafter, 16S rRNA high‐throughput sequencing method, using Hamilton...
Accumulating evidences suggested an association between gut microbiome dysbiosis and impaired glycemic control. Ginsenoside Rb1 (Rb1) is a biologically active substance of ginseng, which serves anti-diabetic effects. However, its working mechanism especially interaction with microbes remains elusive in detail. In this study, we investigated the impact oral supplementation on high fat diet (HFD) induced obesity mice, explored regulating blood glucose. The results showed that higher liver...
Abstract Background Epigenetic changes are plausible molecular sources of clinical heterogeneity in schizophrenia. A subgroup schizophrenia patients with elevated inflammatory or immune-dysregulation has been reported by previous studies. However, little is known about epigenetic genes related to immune activation never-treated first-episode (FES) and its consistency that treated long-term ill (LTS) patients. Methods In this study, epigenome-wide profiling a DNA methylation array was applied...
Synbiotics have revealed the possibility of improving constipation through gut microbiota. The synergistic efficacy Bifidobacterium animalis subsp. lactis BL-99 (BL-99) and fructooligosaccharide (FOS) on not been investigated. Loperamide-induced constipated mice model was established to explore effect BL-99, FOS, BL-99+FOS changes defecation-related parameters, microbiota metabolites. results showed that each alleviated constipation, with synbiotic showing significant in first black stool...
Oyster mushrooms (Pleurotus ostreatus) are one of the most commonly grown edible using compost, which contains high concentrations ammonia. In this study, inoculation oyster mushroom culture substrate with ammonia-assimilating bacterium Enterobacter sp. B12, either before or after composting, reduced ammonia nitrogen content, increased total content and enhanced yield. Co-cultivation P. ostreatus mycelia on potato dextrose agar (PDA) plates containing 200 mM NH4+, B12 reactive oxygen species...
Growing evidence indicates that gut microbiota factors cannot be viewed as independent in the occurrence of obesity. Because microbiome is highly dimensional and complex, studies on interactions between host obesity are still rare. To explore relationship microbiome-host with obesity, we performed multi-omics associations metagenome, intestinal transcriptome, phenotypes divergently selected obese-lean broiler lines. Metagenomic shotgun sequencing generated a total 450 gigabases clean data...
Adenomatous polyps (APs) with inflammation are risk factors for colorectal cancer. However, the role of inflammation-related gut microbiota in promoting progression APs is unknown.
Introduction High intake of dietary fiber is associated with lower incidence cardiovascular diseases. Dietary fiber, functions as a prebiotic, has significant impact on intestinal bacteria composition and diversity. The flora metabolites generated by fermentation not only affect the health intestine but also play role in many extra-intestinal diseases, such obesity, diabetes atherosclerosis. However, mechanism which high diet contributes to development myocardial infarction still unclear....
Au@Pt nanozyme, a bimetallic core–shell structure Au and Pt nanoparticle, has attracted significant attention due to its excellent catalytic activity stability. Here, we propose that improves glucose tolerance reduces TG after four weeks administration. The transcriptomic analysis of mouse liver tissues treated with nanozyme showed changes in genes related lipid metabolism signaling pathways, including glycolysis/gluconeogenesis, pyruvate metabolism, PPAR signaling, insulin signaling....
Background The use of medicinal plant ingredients is one the goals developing potential drugs for treating depression. Compelling evidence suggests that anti-inflammatory medicines may block occurrence We studied effect a natural compound, emodin, on development psychosocial stress-induced depression and underlying mechanisms. Methods Chronic unpredicted mild stress (CUMS) 7 weeks was performed to replicate in rats. sucrose preference test, force swimming open field test were used evaluate...
Background Crohn’s disease (CD) is characterized by repetitive phases of remission and exacerbation, the quality life patients with CD strongly influenced activity, as in active phase experience significantly worse symptoms. To investigate underlying mechanism how course exacerbated based on bi-directionality brain-gut axis (BGA), we conducted a multi-modality neuroimaging study that combined resting-state functional magnetic resonance imaging (rs-fMRI) proton spectroscopy (MRS) to detect...