A5103201271- Hepatitis B Virus Studies
- COVID-19 Clinical Research Studies
- Hepatitis C virus research
- SARS-CoV-2 and COVID-19 Research
- Liver Disease Diagnosis and Treatment
- Nutritional Studies and Diet
- Systemic Sclerosis and Related Diseases
- Long-Term Effects of COVID-19
- Olfactory and Sensory Function Studies
- Dermatologic Treatments and Research
- Diet and metabolism studies
- Dermatology and Skin Diseases
- Gut microbiota and health
- Advanced Chemical Sensor Technologies
- Single-cell and spatial transcriptomics
- Gastrointestinal motility and disorders
- Oceanographic and Atmospheric Processes
- Ocular Surface and Contact Lens
- Geophysics and Gravity Measurements
- Adaptive optics and wavefront sensing
- Obesity, Physical Activity, Diet
- Iron Metabolism and Disorders
- Liver Disease and Transplantation
- Infant Health and Development
- Employment and Welfare Studies
Xiangya Hospital Central South University
2025
Central South University
2017-2025
China Agricultural University
2023-2025
Southeast University
2022-2025
Chengdu Medical College
2025
Research Institute of Wood Industry
2025
Laoshan Laboratory
2025
Second Hospital of Anhui Medical University
2025
Anhui Medical University
2025
Sun Yat-sen University
2020-2025
Importance Cardiovascular-kidney-metabolic (CKM) syndrome—a novel, multistage, multisystem disorder as defined by the American Heart Association—is highly prevalent in US. However, prevalence of CKM stages social determinants health (SDOH) remains unclear. Objective To investigate whether varies SDOH US adults. Design, Setting, and Participants This cross-sectional study used data from National Health Nutrition Examination Survey (1999-2018) included a nationally representative sample adults...
Importance Evidence on the associations of taste function changes from early adulthood to mid late with all-cause mortality is limited. Objective To investigate between subjective perception loss and mortality. Design, Setting, Participants This population-based cohort study used data US National Health Nutrition Examination Survey (2011-2014) linked information Death Index (NDI) included adults aged 40 years older. Data analyses were conducted May 6, 2024, July 22, 2024. Exposures...
Oral propranolol hydrochloride has been the first-line treatment for infantile hemangioma (IH), whereas systemic exposure to potential of causing serious adverse reactions. Dermal delivery is preferable due high local drug concentration and fewer effects. However, (BCS class I) highly hydrophilic difficulty in penetrating stratum corneum (SC) barrier. Dissolving microneedles (MNs) are an efficient tool overcoming barrier SC enhancing dermal delivery. In this study, hydrochloride-loaded...
The gut microbiota plays a crucial role in regulating host metabolism and producing uremic toxins patients with end-stage renal disease (ESRD). Our objective is to advance toward holistic understanding of the ecosystem its functional capacity such patients, which still lacking.Herein, we explore microbiome 378 hemodialytic ESRD 290 healthy volunteers from two independent cohorts via deep metagenomic sequencing metagenome-assembled-genome-based characterization their feces. findings reveal...
Probiotics have garnered increasing attention as a potential therapeutic approach for type 2 diabetes mellitus (T2DM). Previous studies confirmed that Bifidobacterium animalis subsp. lactis MN-Gup (MN-Gup) could stimulate the secretion of glucagon-like peptide-1 (GLP-1) in NCI-H716 cells, but whether has hypoglycemic effect on T2DM vivo remains unclear. In this study, mouse model was constructed, with high-fat diet and streptozotocin mice, to investigate diabetes. Then, different doses (2 ×...
High serum urate levels are the major risk factor for gout. URAT1, primary transporter absorption in kidneys, is well known as an anti-hyperuricemia drug target. However, clinical application of URAT1-targeted drugs limited because their low specificity and severe side effects. The lack structural information impedes elucidation transport mechanism development new drugs. Here, we present cryoelectron microscopy (cryo-EM) structures human URAT1(R477S), its complex with urate, closely related...
Thickened skin is a major clinical feature in patients with systemic sclerosis (SSc). We investigated changes of thickness SSc using both high frequency ultrasound (HFU) and the modified Rodnan score (mRSS) to evaluate feasibility application HFU involvement relationship between profiles. recruited 31 consecutive age-matched sex-matched healthy controls this prospective, cross-sectional study. Skin was measured by an 18-MHz ultrasonic probe at five different sites. Total (TST) categorical...
Chronic infection with hepatitis B virus (HBV) is associated liver cirrhosis and hepatocellular carcinoma. Upon of hepatocytes, HBV covalently closed circular DNA (cccDNA) exists as histone-bound mini-chromosome, subjected to transcriptional regulation similar chromosomal DNA. Here we identify high mobility group AT-hook 1 (HMGA1) protein a positive regulator transcription that binds conserved ATTGG site within enhancer II/core promoter (EII/Cp) recruits factors FOXO3α PGC1α. HMGA1-mediated...
Rats with visceral hypersensitivity often exhibit impaired decision-making abilities. Functional heartburn (FH) is a functional esophageal disease that belongs to the category of gut-brain interaction disorders, associated hypersensitivity. However, ability patients FH remains unclear. We recruited 30 diagnosed based on Rome IV criteria and healthy controls (HCs). All were evaluated using Hamilton Anxiety Scale 17-item Depression Scale-17. Patients also completed gastroesophageal reflux...
Abstract Sea surface temperature (SST) is a key variable in understanding air-sea interactions, changes SST can have profound effects on the global climate and may lead to extreme events such as marine heatwave floods. Accurate prediction of therefore essential for detecting mitigating negative consequences they cause. Numerical model-based predictions are limited by seafloor topography data, parameterization schemes, comprehensive preparation input data computing resources. Recently,...
Objective: To explore the molecular mechanism of miR-4508 regulating inflammatory response human bronchial epithelial cells induced by representative chrysotile asbestos. Methods: The asbestos was ground into ultrafine dust using a horizontal planetary instrument, and epithelium (16HBE) were taken as object infection. Cell survival rate detected cell counting kit-8 method, cytotoxicity lactate dehydrogenase (LDH) kit. released factor IL-6 electrochemical luminescence. IL-8 enzyme-linked...
The traditional Lamaze breathing technique has limitations. We analyzed the effect of our new warm and calm (WC) pattern on incidence fetal intrauterine distress, emergency cesarean delivery, forceps-assisted episiotomy, third- fourth-degree perineal tears, postpartum hemorrhage. Pregnant women who underwent a labor trial at Second Hospital West China University Sichuan between January 2020 November 2023 practiced WC (n = 28,369) were recruited as study group those routine 2016 December 2019...
Abstract The SARS‐CoV‐2 spike (S) protein, a trimeric structure comprising three receptor binding domains (RBDs) and N‐terminal (NTDs), undergoes substantial conformational changes to fusion‐prone open state for angiotensin‐converting enzyme 2 (ACE2) host cell infection. Stabilizing its closed is key antiviral strategy but remains challenging. Here, we introduce S416, novel amphipathic molecule acting as “molecular bolt”. Cryo‐EM study reveals that S416 binds concurrently six sites across...
Abdominal aortic aneurysm (AAA) is a vascular disease strongly associated with immune dysregulation and metabolic disturbances. Although lactate metabolism its process, lactylation, have been implicated in various diseases, their specific role AAA pathogenesis remains poorly understood. In this study, we used multi-faceted approach, integrating single-cell bulk RNA data analyses, the objective of elucidating interrelationship between lactylation response patients. The result revealed...