A5102850136- Cardiac pacing and defibrillation studies
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Cardiovascular Disease and Adiposity
- Cardiac Arrhythmias and Treatments
- Lipoproteins and Cardiovascular Health
- Cardiac Fibrosis and Remodeling
- Atherosclerosis and Cardiovascular Diseases
- Cardiac electrophysiology and arrhythmias
- Cancer-related molecular mechanisms research
- Heart Rate Variability and Autonomic Control
- X-ray Diffraction in Crystallography
- Diabetes Treatment and Management
- Crystal Structures and Properties
- Adipokines, Inflammation, and Metabolic Diseases
- Angiogenesis and VEGF in Cancer
- Crystallization and Solubility Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Health and Risk Factors
- Congenital heart defects research
- Eicosanoids and Hypertension Pharmacology
- Atrial Fibrillation Management and Outcomes
- Nitric Oxide and Endothelin Effects
- Cardiac Structural Anomalies and Repair
- Peroxisome Proliferator-Activated Receptors
Sun Yat-sen University
2016-2025
Sun Yat-sen Memorial Hospital
2016-2025
Guangxi Medical University
2025
Key Laboratory of Guangdong Province
2014-2024
Foshan Second People's Hospital
2024
Weatherford College
2021
University of Chinese Academy of Sciences
2020-2021
Fujian Institute of Research on the Structure of Matter
2020-2021
Chinese Academy of Sciences
2020-2021
Southern Medical University
2014-2021
Abstract Background A growing body of evidence suggests that stem cell-derived exosomal microRNAs (miRNAs) could be a promising cardioprotective therapy in the context hypoxic conditions. The present study aims to explore how miRNA-144 (miR-144), miRNA contained bone marrow mesenchymal cell (MSC)-derived exosomes, exerts effect on cardiomyocyte apoptosis conditions and identify underlying mechanisms. Methods MSCs were cultured using whole adherent method. MSC-derived exosomes isolated total...
Sonodynamic therapy (SDT) and photothermal (PTT) are two effective strategies for the treatment of atherosclerotic plaques. However, low yield reactive oxygen species (ROS) conventional organic sonosensitizers biosafety hyperthermia limit therapeutic efficacy SDT PTT. Herein, we report copper sulfide/titanium oxide heterostructure nanosheets modified with hyaluronic acid (HA) PEG (HA-HNSs) low-intensity sonodynamic mild-photothermal synergistic early CuS/TiO2 (HNSs) show high electron–hole...
The disruption of the balance between fatty acid (FA) uptake and oxidation (FAO) leads to cardiac lipotoxicity, serving as driving force behind diabetic cardiomyopathy (DbCM). Sirtuin 5 (Sirt5), a lysine de-succinylase, could impact diverse metabolic pathways, including FA metabolism. Nevertheless, precise roles Sirt5 in lipotoxicity DbCM remain unknown. This study aims elucidate role underlying mechanism context DbCM. expression myocardial was found be modestly elevated heart failure...
Abstract Background Proliferation of the vasa vasorum has been implicated in pathogenesis atherosclerosis, and is closely associated with resident stem cells within vasculature. C-reactive protein (CRP) positively correlated cardiovascular disease risk, our previous study demonstrated that it induces inflammatory reactions perivascular adipose tissue by targeting adipocytes. Methods Here we investigated whether CRP affected proliferation proangiogenic paracrine activity adipose-derived...
Maintaining proper mitochondrial respiratory function is crucial for alleviating cardiac metabolic disorders during obesity, and mitophagy critically involved in this process. Long non-coding RNA H19 (H19) regulation, but its roles disorders, function, obesity are largely unknown. In study, palmitic acid (PA)-treated H9c2 cell Lep-/- mice were used to investigate vitro vivo, respectively. The effects of on investigated. Moreover, the regulatory mechanisms PA, H19, mitophagy, examined. models...
Pulmonary hypertension (PH) is associated with increased expression of VEGF-A (vascular endothelial growth factor A) and its receptor, VEGFR2 2), but whether how activation signal participates in the pathogenesis PH unclear.VEGF-A/VEGFR2 Y949-dependent vascular leak were investigated lung samples from patients mice exposed to hypoxia. To study their mechanistic roles hypoxic PH, we examined right ventricle systolic pressure, ventricular hypertrophy, pulmonary vasculopathy mutant carrying...
Abstract Objective The triglyceride–glucose (TyG) index has been shown to be a new alternative measure for insulin resistance. However, no study attempted investigate the association of TyG with incident atrial fibrillation (AF) in general population without known cardiovascular diseases. Methods Individuals diseases (heart failure, coronary heart disease, or stroke) from Atherosclerosis Risk Communities (ARIC) cohort were recruited. baseline was calculated as Ln [fasting triglycerides...
De-identification, identifying and removing all protected health information (PHI) present in clinical data including electronic medical records (EMRs), is a critical step making publicly available. The 2014 i2b2 (Center of Informatics for Integrating Biology Bedside) natural language processing (NLP) challenge sets up track de-identification (track 1). In this study, we propose hybrid system based on both machine learning rule approaches the track. our system, PHI instances are first...
Background: Left bundle branch area pacing (LBBAP) is a novel modality with stable parameters and narrow-paced QRS duration. We compared heart failure (HF) hospitalization events echocardiographic measures between LBBAP right ventricular (RVP) in patients atrioventricular block (AVB). Methods Results: This multicenter observational study prospectively recruited consecutive AVB requiring five centers if they received or RVP had left ejection fraction (LVEF) >50%. Data on...
Objective: To explore the role of glycolysis in cardiac fibroblast (CF) activation and fibrosis after myocardial infarction (MI). Method:In vivo: 2-Deoxy-D-glucose (2-DG), a inhibitor, was injected into abdominal cavity MI or sham mice every day. On 28th day, function measured by ultrasonic cardiography, hearts were harvested. Masson staining immunofluorescence (IF) used to evaluate area, western blot identify glycolytic level. In vitro, we isolated CF from sham, with 2-DG treatment mice,...
Atheroclerosis refers to a chronic inflammatory disease featured by the accumulation of fibrofatty lesions in intima arteries. Cardiovasular events associated with atherosclerosis remain major causes mortality worldwide. Recent studies have indicated that ferroptosis, novel programmed cell death, might participate process atherosclerosis. However, ferroptosis landscape is still not clear. In this study, 59 genes were ultimately identified intima. Gene ontology (GO) and Kyoto Encyclopedia...
Abstract Aim To investigate the association between cardiovascular health metrics defined by Life's Essential 8 (LE8) scores and vascular complications among individuals with type 2 diabetes (T2D). Materials Methods This prospective study included 11 033 participants T2D, all devoid of macrovascular diseases (including peripheral artery disease) microvascular (e.g. diabetic retinopathy, neuropathy nephropathy) at baseline from UK Biobank. The LE8 score comprised eight metrics: smoking, body...
Recently, endothelial-mesenchymal transition (EndMT) has been demonstrated to play an important role in the development of atherosclerosis, molecular mechanisms which remain unclear. In present study, scanning electron microscopy directly revealed a widened endothelial space and immunohistofluorescence that EndMT was increased human aorta atherosclerotic plaques. M1 macrophage-derived foam cell (M1-FC) supernatants, but not M2 (M2-FC) induced EndMT. A protein array enzyme-linked...
Despite recent progress in prediction and prevention, heart disease remains a leading cause of death. One preliminary step prevention is risk factor identification. Many studies have been proposed to identify factors associated with disease; however, none attempted all factors. In 2014, the National Center Informatics for Integrating Biology Beside (i2b2) issued clinical natural language processing (NLP) challenge that involved track (track 2) identifying texts over time. This aimed...
Abstract Birefringent materials play a key role in modulating the polarization of light and thus optical communication as well laser techniques science. Designing new, excellent birefringent remains challenge. In this work, we designed synthesized first antimony(III) fluoride oxalate material, KSb 2 C O 4 F 5 , by combination delocalized π‐conjugated [C ] 2− groups, stereochemical active Sb 3+ cations, most electronegative element, fluorine. The groups are not an optimal arrangement crystal...
Abstract Prolonged endoplasmic reticulum (ER) stress is the key driving force behind diabetic cardiomyopathy (DCM). Autophagy extensively implicated in adaptive mechanisms for cell survival. Interleukin‐33 (IL‐33) known to be a potent cardiac protector, but its roles DCM, ER stress, and autophagy are currently unknown. We aimed explore effects of IL‐33 on DCM characterize that play DCM. The were characterized both db/db mice palmitic acid (PA)‐treated cardiomyocytes. manipulators used...
Background: Atherosclerotic cardiovascular diseases accounted for a quarter of global deaths. Most these fatal like coronary atherosclerotic disease (CAD) and stroke occur in the advanced stage atherosclerosis, during which candidate therapeutic targets have not been fully established. This study aims to identify hub genes possible regulatory involved treatment plaques. Material/Methods: Microarray dataset GSE43292 GSE28829 , both containing plaques group early lesions group, were obtained...
Deep-ultraviolet (deep-UV) (wavelengths of <200 nm) nonlinear optical (NLO) materials are playing an increasingly important role because their significant technological applications in advanced scientific instruments. In recent years, the non-π-conjugated systems have received extensive attention as new emerging sources deep-UV NLO materials. Here, a material, K2Zn3(SO4)(HSO4)2F4, has been successfully obtained by hydrothermal method. It layered structure formed [Zn3(SO4)(HSO4)2F3]∞ layers...
A synergistic effect of diverse functional groups leads to an organic–inorganic hybrid birefringent material (CN<sub>4</sub>H<sub>7</sub>)SbC<sub>2</sub>O<sub>4</sub>F<sub>2</sub>(H<sub>2</sub>O)<sub>0.5</sub>, which exhibits a response (Δ<italic>n</italic> = 0.126@546 nm) that is almost equal the famous α-BaB<sub>2</sub>O<sub>4</sub>.