A5101613585- Acute Myeloid Leukemia Research
- Cervical Cancer and HPV Research
- Phytochemistry and Biological Activities
- Luminescence Properties of Advanced Materials
- Multiple and Secondary Primary Cancers
- Hematological disorders and diagnostics
- Epigenetics and DNA Methylation
- Colorectal Cancer Screening and Detection
- Acute Lymphoblastic Leukemia research
- Immune cells in cancer
- Medical Imaging and Pathology Studies
- Herpesvirus Infections and Treatments
- Cardiovascular Disease and Adiposity
- Vascular Malformations Diagnosis and Treatment
- Reproductive System and Pregnancy
- Heterotopic Ossification and Related Conditions
- Tea Polyphenols and Effects
- Flavonoids in Medical Research
- Chemokine receptors and signaling
- Tracheal and airway disorders
- Palliative Care and End-of-Life Issues
- Cardiac Imaging and Diagnostics
- Acne and Rosacea Treatments and Effects
- Family Caregiving in Mental Illness
- Celiac Disease Research and Management
First Affiliated Hospital of Kunming Medical University
2025
Kunming Medical University
2025
Institute of Hematology & Blood Diseases Hospital
2019-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
Tianjin Medical University
2022-2025
Shanghai Artificial Intelligence Laboratory
2023
Beijing Academy of Artificial Intelligence
2023
Union Hospital
2019-2022
Huazhong University of Science and Technology
2019-2022
China Medical University
2021
Abstract Background and Aims Metastasis is the primary cause of cancer mortality, colorectal (CRC) frequently metastasizes to liver. Our previous studies demonstrated critical role KIAA1199 in tumor invasion metastasis CRC. In present study, we described an immune regulatory effect that creates a permissive environment for metastasis. Approach Results Flow cytometry was used examine effects on infiltration cells. Neutrophils T cells were isolated, stimulated, and/or cultured vitro function...
Recently, endothelial-mesenchymal transition (EndMT) has been demonstrated to play an important role in the development of atherosclerosis, molecular mechanisms which remain unclear. In present study, scanning electron microscopy directly revealed a widened endothelial space and immunohistofluorescence that EndMT was increased human aorta atherosclerotic plaques. M1 macrophage-derived foam cell (M1-FC) supernatants, but not M2 (M2-FC) induced EndMT. A protein array enzyme-linked...
CRC (Colorectal cancer) is one of the most common causes death worldwide and in US (United States).In this study, we aim to perform a population-based analysis on cause among patients with US.A total 834,510 diagnosed between 1975 2016 were selected from SEER (Surveillance, Epidemiology, End Results) program.Causes characterized SMRs (standardized mortality ratios) non-cancer calculated.Among all included 531,507 deaths recorded, which 51.3% due CRC, 10.3% other cancers, 38.4%...
Previous studies have suggested that patients with cancer may be at an increased risk of death from unintentional injury, but to our knowledge, no large examined the rates injury among cancer.To characterize incidence in United States.This retrospective cohort study included diagnosed a first primary between January 1, 1973, and December 31, 2015, identified Surveillance, Epidemiology, End Results (SEER) program data. Comparisons general US population were based on mortality data collected...
Cellular prion protein (PrP C ), known for its pathological isoform in diseases such as Creutzfeldt-Jakob disease, is primarily expressed the nervous system but has also been detected blood and urine of individuals with renal dysfunction. However, role PrP development disease unexplored. Here, we showed that was up-regulated fibrotic lesions biopsies from patients chronic kidney (CKD), predominantly proximal tubular epithelial cells (PTECs). Furthermore, expression positively correlated...
Abstract Primary renal lymphoma (PRL) is a rare lymphoid malignancy with only few cases reported in the literature. We performed population-based study of PRL to determine its incidence, clinical characteristics and factors associated survival using Surveillance, Epidemiology, End Results (SEER) database. identified 723 patients PRL. The most common histological subtype was diffuse large B-cell (56.3%). incidence mortality rate 0.053/100,000 person-years 0.036/100,000 person-years,...
Perivascular adipose tissue (PVAT) accelerates plaque progression and increases cardiovascular risk. We tested the hypothesis that PVAT contributed to vulnerability investigated whether endoplasmic reticulum stress (ER stress) in played an important role vulnerable plaque. transplanted thoracic aortic or subcutaneous as a control, from donor mice carotid arteries of recipient apolipoprotein E deficient (apoE−/−) after removing artery collar placed for 6 weeks. Two weeks transplantation, ER...
Key points Cardiospheres (CSps) are a promising new form of cardiac stem cells with advantage over other for myocardial regeneration, but direct implantation CSps by conventional routes has been limited due to potential embolism. We have implanted into the pericardial cavity and systematically demonstrated its efficacy regarding infarction. Stem cell potency viability can be optimized in vitro prior pre‐conditioning fluid hydrogel packing. Transplantation improved function alleviated...
Abstract Aim Inflammation within the perivascular adipose tissue (PVAT) in obesity plays an important role cardiovascular disorders. C-reactive protein (CRP) level patients is significantly increased and associated with occurrence progression of disease. We tested hypothesis CRP derived from PVAT contributes to vascular remodeling after injury. Methods A high-fat diet (HFD) expression PVAT. transplanted thoracic aortic wild-type (WT) or transgenic CRP-expressing (CRPTG) mice injured femoral...
Abstract Background In 2014, a novel tick-borne virus of the Flaviviridae family was first reported in Mogiana region Brazil and named tick (MGTV). Thereafter, Jingmen (JMTV), Kindia (KITV), Guangxi (GXTV)—evolutionarily related to MGTV—were reported. Results present study, we used small RNA sequencing (sRNA-seq) detect viruses ticks discovered new MGTV strain Amblyomma testudinarium collected China’s Yunnan Province 2016. We obtained full-length genome sequence this Yunnan2016 (GenBank:...
Abstract Background Long non‐coding RNA (lncRNA) H19 is involved in the carcinogenesis, progression, and metastasis of colorectal cancer (CRC). Recently, a few studies explored relationship between lncRNA gene rs2839698 polymorphism CRC risk, but with conflicting findings. Materials methods A case‐control study 315 cases 441 controls was designed Chinese population. Genotyping performed using PCR‐RFLP. Results It found associated decreased risk (AA vs GG: OR, 0.73; 95% CI, 0.54‐0.98; P =...