A5104323385- Gut microbiota and health
- Molecular Sensors and Ion Detection
- Cancer-related molecular mechanisms research
- Radiomics and Machine Learning in Medical Imaging
- Effects of Radiation Exposure
- Sperm and Testicular Function
- Respiratory viral infections research
- Prostate Cancer Treatment and Research
- Traditional Chinese Medicine Analysis
- Prostate Cancer Diagnosis and Treatment
- Menstrual Health and Disorders
- Advanced Sensor and Control Systems
- Genetic factors in colorectal cancer
- Reproductive Biology and Fertility
- Connective tissue disorders research
- Advanced X-ray and CT Imaging
- Gastric Cancer Management and Outcomes
- Metal-Organic Frameworks: Synthesis and Applications
- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Hormonal and reproductive studies
- Immune cells in cancer
- Advanced Algorithms and Applications
- Pharmacogenetics and Drug Metabolism
- Biochemical effects in animals
Tongji Hospital
2020-2025
Xi'an Jiaotong University
2025
Hubei Cancer Hospital
2025
Huazhong University of Science and Technology
2020-2025
Henan University of Technology
2024
Chongqing University
2014-2023
Ningxia Medical University General Hospital
2022
Ningxia Medical University
2022
Chongqing Cancer Hospital
2021-2022
Peking University Third Hospital
2021
Despite the encouraging efficacy of anti-PD-1/PD-L1 immunotherapy in microsatellite-instability-high/deficient mismatch repair (MSI-H/dMMR) advanced gastrointestinal cancer, many patients exhibit primary or acquired resistance. Using multi-omics approaches, we interrogate gut microbiome, blood metabolome, and cytokines/chemokines with MSI-H/dMMR cancer (N = 77) at baseline during treatment. We identify a number microbes (e.g., Porphyromonadaceae) metabolites arginine) highly associated...
Abstract Radio-immunotherapy has antitumor activity but also causes toxicity, which limits its clinical application. JS-201 is a dual antibody targeting PD-1 and TGF-β signaling. We investigated the antitumour effect of combined with radiotherapy on radiation-induced lung injury (RILI). Different tumor models were established to detect effects combination RT, RILI observe JS-201. Transcriptome sequencing showed that optimized TME by inhibiting extracellular matrix formation angiogenesis....
An innovative sandwich-structural Fe-based metal-organic framework magnetic material (Fe3O4@SW-MIL-101-NH2) was fabricated using a facile solvothermal method. The characteristic properties of the were investigated by field emission scanning electron microscopy, transmission microscopy (TEM), energy-dispersive X-ray spectroscopy, Fourier transform infrared powder diffraction, vibrating sample magnetometry, and Brunauer-Emmett-Teller measurements. Fe3O4@SW-MIL-101-NH2 is associated with...
Radiation pneumonitis is a common complication of thoracic irradiation for lung cancer patients. The healthy gut microbiota plays an important role in the local mucosal defense process as well pulmonary immunomodulation host. However, effect intestinal on radiation not understood. Here we studied how affected host response to pneumonitis. C57BL/6 mice were administered antibiotics induce disequilibrium microbiota, and subsequently irradiated. We found that served protective mediator against...
Lower respiratory tract infection (LRTI) is one of the major reasons for childhood mortality that threaten health public. We aimed to investigate epidemiological pathogens and their analysis among children with LRTI. Sputum specimens were collected polymerase chain reaction detection microbiological tests identify viral bacterial infection. The serological separated from venous blood using Mycoplasma pneumoniae Chlamydia detection. virus was confirmed in 86.2% children. Human rhinovirus...
The aim of this study was to explore the mechanism underlying antidepression activity paeoniflorin, main active ingredient paeony extract and Shuyu capsules, determine its effect on calmodulin/calmodulin-dependent protein kinase II (CaM/CaMKII) signalling pathway possible target, voltage-gated calcium channel (Cav). Rats at nonacceptance stage were selected for premenstrual syndrome (PMS) depression modelling. Behavioural assays used model testing. given extract, bupleurum. Western blot...
Abstract Through digital rectal examinations (DRE) and routine prostate‐specific antigen (PSA) screening, early prostate cancer (PC) treatment has become possible. However, PC is a complex heterogeneous disease. In vivo, cells can invade adjacent tissues metastasize to other resulting in hard cures. Therefore, the key improving patients’ survival time preventing cells’ metastasis. We used mass spectrometry profile primary patients with versus without metastatic PC. named these two groups of...
Abstract Introduction Quality evaluation of Huang‐qin is significant to ensure its clinical efficacy. Objective This study aims establish an accurate, rapid and comprehensive quality method overcome the time‐consuming laborious shortcomings traditional herbal medicine assessment methods. Methods The contents baicalin, baicalein scutellarin in from five different origins were analyzed by FT‐IR NIR spectra combined with multivariate data technology. was evaluated TOPSIS consistency analysis...
To investigate function of somatostatin receptor 5 antisense RNA 1 (SSTR5-AS1) in esophageal carcinoma (ESCA).
Objective To investigate the dynamic changes of intestinal flora in septic model mice. Methods Forty-two male SPF C57BL/6 mice were selected, sepsis was reproduced by cecal ligation and puncture (CLP), experimental divided into CLP 6-12 hours group (n = 9) 1, 2, 3 days (all n 10) Sham 3) according to time points after modeling. Intestinal 16S rRNA sequencing carried out within feces from colonic lumen mice, effective sequences clustered obtain an operational classification unit (OTU) for...
Anti-Helicobacter pylori (HP) therapy succeeded in regressing gastric B-cell lymphomas (gBL) with a close relation to infestation of HP, although the exact mechanism anti-HP gBL has not yet been clarified. In order see part mechanism, this study analyzed stromal cells 34 cases comprised 11 mucosa-associated lymphoid tissue (MALT) type and 24 diffuse large lymphoma (DLBL) by means immunohistochemistry CD3, CD5, CD79a, CD68, CD21, S100 protein, thymidine phosphorylase (TP) inducible nitric...
During the granulation process of Iron ore sinter mixture, there are many factors affect granulating effect, such as chemical composition, size distribution, surface feature particle, and so on. Some researchers use traditional fitting calculation methods like least square method regression analysis to predict effects, which exists big error. In order it better, we build improved BP (Back propagation) neural network model carry out data processing, then obtain better effect than methods. DOI...