A5100957904- Reproductive tract infections research
- Reproductive Physiology in Livestock
- Reproductive System and Pregnancy
- Urinary Tract Infections Management
- Pelvic floor disorders treatments
- Tea Polyphenols and Effects
- Cervical Cancer and HPV Research
- Genital Health and Disease
- Gut microbiota and health
- Ginkgo biloba and Cashew Applications
- Asthma and respiratory diseases
- Diet, Metabolism, and Disease
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Reproductive Health and Contraception
- Immune cells in cancer
- Advanced Decision-Making Techniques
- Parvovirus B19 Infection Studies
- RNA Research and Splicing
- Tryptophan and brain disorders
- Antimicrobial Peptides and Activities
- Liver Disease Diagnosis and Treatment
- IL-33, ST2, and ILC Pathways
- Biochemical Analysis and Sensing Techniques
- Vitamin D Research Studies
- Autoimmune Bullous Skin Diseases
Xiangya Hospital Central South University
2015-2025
Central South University
2015-2025
Soochow University
2025
First Affiliated Hospital of Soochow University
2025
Beijing Radiation Center
2025
Xijing Hospital
2024
Air Force Medical University
2014-2024
Yangzhou University
2015-2024
ShenZhen People’s Hospital
2023
First Affiliated Hospital of Xi'an Jiaotong University
2023
Intravaginal infection with Chlamydia muridarum in mice can ascend to the upper genital tract, resulting hydrosalpinx, a pathological hallmark for tubal infertility women infected C. trachomatis. Here, we utilized vivo imaging of following an intravaginal inoculation and confirmed rapid ascent chlamydial organisms from lower tracts. Unexpectedly, muridarum-derived signal was still detectable abdominal area 100 days after inoculation. Ex mouse organs revealed that long-lasting presence...
Ginkgo biloba L, as a Mesozoic relict tree species specialized in China, has attracted much attention for its unique chemical composition and pharmacological properties, most of the research focused on leaves (GBL). Our preliminary found that flowers (GBF) were superior to GBL terms anti-radiation activity, but underlying cause this discrepancy activity remains elusive. Therefore, present study aimed systematically compare nutritional compositions GBF investigate intrinsic mechanism their...
Backgrounds: Ginkgo biloba L. has attracted much attention for its unique chemical composition and pharmacological properties, most of the research focused on leaves (GBL). Our preliminary found that flowers (GBF) were superior to GBL in terms anti-radiation activity, but underlying cause this discrepancy activity remains elusive. Objectives: The aim study was systematically compare nutritional leaves, further elucidate material basis medicinal value flowers, conduct comparative studies...
Animal infection models play significant roles in the study of bacterial pathogenic mechanisms and host-pathogen interactions, as well evaluating drug vaccine efficacies. Chlamydia trachomatis is responsible for infections various mucosal tissues, including eyes urogenital, respiratory, gastrointestinal tracts. Chronic can result severe consequences such trachoma-induced blindness, ectopic pregnancy, infertility. While intravaginal inoculation C. muridarum mimics natural route sexual...
Pulmonary fibrosis (PF) is a common complication in those interstitial lung diseases patients, which will result poor prognosis and short survival.Traditional therapeutic methods such as glucocorticoid cytotoxic drugs are insufficient for treating PF may cause severe side effects.Recent studies showed that traditional Chinese herbal abstraction Tanshinone IIA (TIIA) was displayed significant anti-PF effects animal models.However, the exact mechanisms underlying protective of TIIA were not...
Chlamydia muridarum is known to colonize in the gastrointestinal tract for long periods of time, which has been hypothesized serve as a reservoir spreading genital tract. To test this hypothesis, luciferase-expressing C. was used establish long-lasting infection mouse following either intragastric or intrarectal inoculations. In vivo imaging revealed significant bioluminescent signals mainly abdominal area throughout experiments. Ex localized tract, confirmed by monitoring organisms...
Chlamydia trachomatis is responsible for infections in various mucosal tissues, including the eyes, urogenital, respiratory, and gastrointestinal tracts. Chronic can result severe consequences such as blindness, ectopic pregnancy, infertility. The underlying mechanisms leading to these diseases involve sustained inflammatory responses, yet thorough comprehension of remains elusive. Chlamydial biologists employ multiple methods, integrating biochemistry, cell biology, genetic tools identify...
CPAF (chlamydial protease-like activity factor), a Chlamydia serine protease, is activated via proximity-induced intermolecular dimerization that triggers processing and removal of an inhibitory peptide occupying the substrate-binding groove. An active homodimer two identical intramolecular heterodimers, each consisting 29-kDa N-terminal 35-kDa C-terminal fragments. However, critical residues for dimerization, catalytic activity, were defined in cell-free systems. Complementation...
Sexually transmitted Chlamydia, which can cause fibrotic pathology in women's genital tracts, is also frequently detected the gastrointestinal tract. However, medical significance of Chlamydia remains unclear. A murine readily spreads from mouse tract to while inducing oviduct blockage or hydrosalpinx. We previously proposed a two-hit model might induce second hit promote pathology, and we are now providing experimental evidence for testing hypothesis. First, chlamydial mutants that...
ABSTRACT Although Chlamydia -induced hydrosalpinx in women and mice has been used as a surrogate marker for tubal infertility, the medical relevance of nontubal pathologies, such uterine horn dilation, developed following chlamydial infection remains unclear. We now report that dilation correlates with glandular duct detected microscopically muridarum infection. The dilated ducts pushed lumen to closure or even broke through myometrium develop extrusion outside horn. severity scores observed...
ABSTRACT Intravaginal infection with plasmid-competent but not plasmid-free Chlamydia muridarum induces hydrosalpinx in mouse upper genital tract, indicating a critical role of the plasmid chlamydial pathogenicity. To evaluate contribution to ascension and activation tubal inflammation, we delivered C. directly into endometrium by intrauterine inoculation. We found that three six strains tested, including CBA/J, C3H/HeJ, C57BL/6J, developed significant hydrosalpinges when 1 × 10 7...
White tea (Camillia sinensis L.) is the least processed tea, and due to simpler processing steps involved, its flavor nutritive compound composition disturbed. However, only a limited number of research has explored key metabolomic changes during white (especially drying). The freshly harvested leaves C. var. Tieguanyin were initially withered at room temperature for 72 h, first-dried on fire 70°C 3 h. Then, they spread 7 days fully dried 80°C 4 followed by cooled temperature. metabolome...
Chlamydia is known to both ascend the upper genital tract and spread gastrointestinal following intravaginal inoculation. Gastrointestinal was recently reported promote chlamydial pathogenicity in since mice intravaginally inoculated with an attenuated strain, which alone failed develop pathology tract, were restored hydrosalpinx by intragastric coinoculation wild-type Chlamydia. promoted via indirect mechanism gut did not directly lumen. In current study, we further investigated role of...
Chlamydia trachomatis is a leading infectious cause of infertility in women due to its induction lasting pathology such as hydrosalpinx. muridarum induces mouse hydrosalpinx because C. can both invade tubal epithelia directly (as first hit) and induce lymphocytes promote indirectly second hit). In the current study, critical role CD8+ T cells chlamydial was validated wild type C57BL/6J mice OT1 transgenic mice. failed develop partially failure their recognize antigens. from naive rescued...
The objective was to explore the value of triglyceride glucose index and related indicators in predicting hepatic steatosis type 2 diabetes patients (T2DM) with different body mass indexes (BMI). Clinical data from 221 hospitalised withT2DM, diagnosed via transient elastography, were collected analysed. Patients a BMI 24 kg/m² or higher designated as high-BMI group, while those below comprised low-BMI group. Relevant indicators, including (TyG), TyG-BMI (TyG-BMI), TyG-waist circumference...
Chlamydia trachomatis is one of the most common sexually infections that cause infertility, and its genital infection induces tubal adhesion hydrosalpinx. Intravaginal muridarum in mice can induce hydrosalpinx upper tract it has been used for studying C. pathogenicity. DBA2/J strain were known to be resistant chlamydial induction In this study, we took advantage feature evaluate role antibiotic induced dysbiosis Antibiotics (vancomycin gentamicin) orally administrated gut mice. The with or...
To investigate the expression and clinical significance of RhoH gene in bone marrow cells leukemia patients.31 cases 15 non-tumor as controls were collected. The was detected by real-time quantitative PCR (RQ-PCR). median level used cut-off value. newly diagnosed patients divided into high group low group. relationship different levels with features prognosis analyzed.The mRNA 31 significantly lower than that control group, ALL AML (P＜0.05). Compared proportion marraw blasts LDH increased...