A5101507266- Intestinal and Peritoneal Adhesions
- Esophageal and GI Pathology
- Cell Adhesion Molecules Research
- Proteoglycans and glycosaminoglycans research
- Neurological Disease Mechanisms and Treatments
- Ginkgo biloba and Cashew Applications
- Glycosylation and Glycoproteins Research
- Retinal Imaging and Analysis
- Clinical Nutrition and Gastroenterology
- Drug-Induced Hepatotoxicity and Protection
- Retinal Diseases and Treatments
- Liver physiology and pathology
- Acute Ischemic Stroke Management
- Phytochemistry and biological activity of medicinal plants
- Food composition and properties
- Colorectal Cancer Surgical Treatments
- Water Treatment and Disinfection
- Cancer, Lipids, and Metabolism
- Metastasis and carcinoma case studies
- Pharmacogenetics and Drug Metabolism
- Long-Term Effects of COVID-19
- Healthcare and Venom Research
- Ferroptosis and cancer prognosis
- Infectious Encephalopathies and Encephalitis
- Proteins in Food Systems
Beijing Radiation Center
2025
Hospital of Hebei Province
2018-2025
China Animal Health and Epidemiology Center
2025
Beijing Tsinghua Chang Gung Hospital
2023-2024
Tsinghua University
2023-2024
Beijing University of Technology
2023-2024
National Institutes of Pharmaceutical Research and Development (China)
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2023
First Affiliated Hospital of Kunming Medical University
2023
Kunming Medical University
2023
Impaired wound healing in diabetics usually leads to life-threatening complications. To develop a system for fastening skin efficiently and safely diabetics, thermos-sensitive hydrogel containing the nanodrug, loaded form of gelatin microspheres (GMs), was designed deliver curcumin (Cur) as therapeutic drug. Cur is naturally existing polyphenolic compound with broad range biological functions useful potential therapies. Because molecule has weakness both bioavailability vivo stability,...
Members of the aquaporin (AQP) family have been suggested to transport aluminum (Al) in plants; however, Al form transported by AQPs and roles tolerance remain elusive. Here we report that NIP1;2, a plasma membrane-localized member Arabidopsis nodulin 26-like intrinsic protein (NIP) subfamily AQP family, facilitates Al-malate from root cell wall into symplasm, with subsequent xylem loading root-to-shoot translocation, which are critical steps an internal mechanism We found NIP1;2 transcripts...
Intracellular lipid accumulation is commonly seen in fibrotic livers, but its exact role liver fibrosis remains elusive. Here, we established a multimodal nonlinear optical microscopy to quantitatively map distribution of biomolecules livers. Our data revealed that unsaturated triglycerides were predominantly accumulated central vein area during not portal area. Moreover, the homeostasis was remarkably dysregulated late-stage compared early-stage fibrosis, including increased with decreased...
Purpose . To characterize the economic and quality of life burden diabetic macular edema (DME) in Canadian patients. Patients Methods 145 patients with DME were followed for 6 months monthly telephone interviews medical chart reviews at 0, 3, 6. Visual acuity worst-seeing eye was assessed 0 DME-related healthcare costs determined over months, vision-related (National Eye Institute Functioning Questionnaire) generic (EQ-5D) Results Mean age 63.7 years: 52% male 72% had bilateral DME. At...
African swine fever is a highly transmissible and lethal infectious disease caused by the virus (ASFV), which has considerably impacted global industry. Lipid metabolism plays vital role in sustaining lipid energy homeostasis within cells influences viral life cycle. In this study, we found that ASFV infection disrupts host. Transcriptomic analysis of infected with revealed levels significantly changed as duration progressed. The intracellular cholesterol host exhibited pattern similar to...
Ginkgo biloba L, as a Mesozoic relict tree species specialized in China, has attracted much attention for its unique chemical composition and pharmacological properties, most of the research focused on leaves (GBL). Our preliminary found that flowers (GBF) were superior to GBL terms anti-radiation activity, but underlying cause this discrepancy activity remains elusive. Therefore, present study aimed systematically compare nutritional compositions GBF investigate intrinsic mechanism their...
Backgrounds: Ginkgo biloba L. has attracted much attention for its unique chemical composition and pharmacological properties, most of the research focused on leaves (GBL). Our preliminary found that flowers (GBF) were superior to GBL in terms anti-radiation activity, but underlying cause this discrepancy activity remains elusive. Objectives: The aim study was systematically compare nutritional leaves, further elucidate material basis medicinal value flowers, conduct comparative studies...
Matrix metalloproteinases (MMPs), mostly abundant in the tumor extracellular matrix (ECM), cells, and vasculatures, are closely correlated with progression metastasis. In this case, making use of MMPs was supposed to achieve site-specific drug delivery a satisfactory treatment effect. Herein, we rationally developed novel microenvironment cell dual-targeting nanoparticle by integrating chemotherapeutic-loaded drug-loaded carrier versatile polypeptide-LinTT1-PVGLIG-TAT (LPT) which is composed...
A hierarchical superhydrophobic Al-Li layered double hydroxide (LDH) films with different Li+/Al3+ molar ratios of 1:1, 1:2, 2:1, pH value 11.5 and reaction temperature 125 °C, have been fabricated on the surface Mg-5Li-1Al (LA51) alloys by hydrothermal method following characteristics controllable cation structure exchangeable anion between layers. The properties were investigated X-ray diffractometer (XRD), scanning electron microscope (SEM) energy dispersive spectrometer (EDS). XRD SEM...
As heavy metals in soil could enrich biomass and pose health risk to human, it is vital monitor their contaminations ensure qualified agricultural production. In this study, we collected >4000 samples from fields Shanghai during 2010∼2020, unveiled metal contamination status metropolitan. We found that although has a long industrialization history, the levels are within safe ranges according national standard. Specifically, median of Cd, Hg, As, Pb, Cr Cu 0.11, 0.13, 7.47, 23.80, 41.00 28.30...
This study describes the extraction, preliminary characterization and evaluation of in vitro antitumor antioxidant activities polysaccharides extracted from Mentha piperita (MPP). The optimal parameters for extraction MPP were obtained by Box-Behnken experimental design response surface methodology (RSM) at ratio water to raw material 20, time 1.5 h temperature 80 °C. Chemical composition analysis showed that was mainly composed glucuronic acid, galacturonic glucose, galactose arabinose,...
The nasopharyngeal microbiota is composed of a variety not only the true commensal bacterial species but also two-face pathobionts, which are one harmless and other highly invasive deadly pathogen. In previous study, we found that diversity was lost in severe influenza patients.
The complexity of chemical components herbal medicines often causes great barriers to toxicity research. In our previous study, we have found the critical divergent hepatotoxic potential a pair stilbene isomers in famous traditional Chinese herb, Polygonum multiflorum (Heshouwu Chinese). However, high-throughput vitro evaluation for such stereoisomerism-dependent hepatotoxicity is challenge. this used hepatic organoids-based system conjunction with using high content imaging differentiate...
CD44 is a cell adhesion molecule implicated in leukocyte and migration, co-stimulation of T cells, tumor metastasis. CD45 leukocyte-specific protein tyrosine phosphatase that dephosphorylates the Src family kinases, Lck Fyn, cells. Positive regulation by required for its effective participation receptor signaling events. Here, immobilized antibody induced distinctive spreading CD45−, but not CD45+, this correlated with induction tyrosine-phosphorylated proteins. Two focal Pyk2 and, to lesser...