A5101716000- Antibiotic Resistance in Bacteria
- Infectious Disease Case Reports and Treatments
- Streptococcal Infections and Treatments
- Vibrio bacteria research studies
- Long-Term Effects of COVID-19
- Hepatitis B Virus Studies
- Infectious Encephalopathies and Encephalitis
- Infections and bacterial resistance
- Glioma Diagnosis and Treatment
- RNA Research and Splicing
- Phytoplasmas and Hemiptera pathogens
- Eicosanoids and Hypertension Pharmacology
- Actinomycetales infections and treatment
- MicroRNA in disease regulation
- Fungal Infections and Studies
- Acute Kidney Injury Research
- Liver Disease Diagnosis and Treatment
- Parasitic Infections and Diagnostics
- Genetic factors in colorectal cancer
- Esophageal Cancer Research and Treatment
- Genomics, phytochemicals, and oxidative stress
- Molecular Biology Techniques and Applications
- Nerve injury and regeneration
- Cellular Mechanics and Interactions
- Brucella: diagnosis, epidemiology, treatment
Tianjin Medical University
2024
Tianjin Children's Hospital
2024
Tianjin University
2024
Capital Medical University
2013-2022
Beijing Ditan Hospital
2013-2022
Peking University
2021
Capital University
2020
Second Military Medical University
2020
Beijing Hospital
2011-2013
National Center for Clinical Laboratories
2011-2012
Abstract A hospital‐based case‐control study of oesophageal cancer was carried out in the Heilongjiang Province, a low‐risk area for China. From May 1985 to 1989, 196 histologically confirmed cases and 392 controls with other (non‐neoplastic) diseases were personally interviewed wards 5 major hospitals. Information obtained about usual consumption early 1980s 32 contributors diet province, socio‐demographic status, smoking alcohol consumption. Odds ratios (OR) from logistic regression...
Aim: The purpose of this study was to determine the genetic polymorphisms CYP2D6 gene and elucidate allele distribution pattern in Chinese Han population. Materials & methods: We used PCR bidirectional sequencing methods analyze all nine exons 2129 unrelated, healthy subjects from two geographical locations China: northern southern regions. Results: In total, 165 mutated sites were detected participants, which 67 reported for first time. Among these novel mutation sites, 22 nonsynonymous 12...
The nasopharyngeal microbiota is composed of a variety not only the true commensal bacterial species but also two-face pathobionts, which are one harmless and other highly invasive deadly pathogen. In previous study, we found that diversity was lost in severe influenza patients.
Rhodococcus equi is a zoonotic opportunistic pathogen that mainly infects immunodeficient individuals, such as those with HIV infection. In R. equi-infected serious lung lesions can develop and death may result without appropriate antiviral treatment. This bacterium rare in clinic there little information regarding its diagnosis To improve our understanding, this case report describes the treatment of patient complicated infection from Ditan Hospital, Beijing, China.
Eur J Clin Invest 2012; 42 (7): 751–759 Abstract Background Colorectal cancer is one of the most rapidly increasing cancers in world, and accumulation alterations oncogenes, tumour suppressor genes mismatch repair (MMR) contributes to colorectal tumorigenesis. Thus, we investigated 14 microsatellite loci adjacent MMR genes, p53, adenomatous polyposis coli (APC) K‐ras 52 Chinese patients with cancer. Materials Methods We performed fluorescent polymerase chain reaction capillary...
We reported that the complete genome sequence of SARS-Coronavirus-2 (SARS-CoV-2) was obtained from a cerebrospinal fluid (CSF) sample by ultrahigh-depth sequencing. Fourteen days after onset, seizures, maxillofacial convulsions, intractable hiccups and significant increase in intracranial pressure developed an adult coronavirus disease 2019 patient. The SARS-CoV-2 indicates can invade central nervous system. In future, along with system assessment, pathogen detection other indicators are...
Abstract Background With the increase of detection rate and long treatment period, nocardiosis has become a noticeable problem in China. However, there are limited large-scale studies on epidemiology antimicrobial susceptibility profiles clinical Nocardia spp. The present study aimed to explore species distribution drug pattern 82 isolates from three tertiary hospitals China by multilocus sequence analysis (MLSA) broth microdilution (BMD) method. Results Pulmonary (90.2%) was most common...
Rhodococcus equi is a zoonotic pathogen that can cause fatal disease in patients who are immunocompromised. At present, the epidemiology and pathogenic mechanisms of R. infection not clear. This study characterized genomes 53 strains from different sources. Pan-genome analysis showed all contained 11481 pan genes, including 3690 core genes 602 ~ 1079 accessory genes. Functional annotation genome focused on related to basic lifestyle, such as storage expression metabolic genetic information....
Acinetobacter baumannii has become a major healthcare threat that causes nosocomial infections, especially in critically ill patients. The spread of carbapenem-resistant A. (CRAB) strains long been clinical concern. It is important to study the epidemiology and virulence characteristics different CRAB isolates order tailor infection prevention antibiotic prescribing. In this study, total 71 were collected hospital, infections analyzed. genomic phylogenetic relationships elucidated based on...
To evaluate the urinary levels of 8-oxo-7,8-dihydro-2'deoxyguanosine (8-oxo-dGsn) and 8-oxo-7,8-dihydroguanosine (8-oxo-Gsn) in liver injury patients with hepatitis B virus (HBV) infection to explore relationship between 8-oxo-dGsn or 8-oxo-Gsn degree damage. We enrolled 138 HBV 169 age- sex-matched healthy controls this study. A sensitive accurate isotope-diluted liquid chromatograph mass spectrometer/mass spectrometer (LC-MS/MS) method was used measure 8-oxo-dGsn. Simultaneously,...
Enterococcus faecalis is commonly found as a commensal gut bacteria, but some linages have caused increasing extra-gastrointestinal infections. In particular, strains with high-level virulence or antimicrobial resistance are prevalent in healthcare settings nosocomial pathogens. This study was performed to elucidate the epidemiological characteristics and susceptibility profiles of E. causing infections Chinese general hospital over 4-year period.We collected 77 isolates from patients at 14...
Abstract Background This study aimed to investigate the correlation of long intergenic non‐coding RNA 511 (LINC00511) with clinicopathological characteristics and overall survival (OS) in osteosarcoma patients explore its function vitro vivo. Methods Tumor tissues adjacent from 45 were acquired, LINC00511 expression was detected. In vitro, detected cell lines osteoblast line. overexpression‐treated (OE‐LINC00511) nonsense (OE‐control) MG‐63 Saos‐2 cells cultured, followed by assessment...
Cryptococcus neoformans is an environmental fungal pathogen that causes opportunistic infections and severe disseminated meningoencephalitis, mainly in immunocompromised patients such as those with acquired immunodeficiency syndrome (AIDS). In this study, the clinical characteristics, treatment protocols, outcomes of 70 AIDS infection at Beijing Ditan Hospital were retrospectively analyzed. We performed antimicrobial sensitivity tests multilocus sequence typing (MLST) on C. isolates from...
Aim: To investigate the anticancer effects of Jinlong capsule (JLC) against human glioblastoma cells and possible underlying mechanism. Methods: Cell Counting Kit-8 colony formation assay were adopted for analysis cell viability. invasion migration evaluated by transwell wound healing assays. Then, expression level mammalian target rapamycin (mTOR), phosphorylated mTOR (p-mTOR), S6 (p-S6) determined western blotting. Results: The results showed that JLC significantly inhibited proliferation,...
HCV patients are usually under substantial oxidative stress because of viral infection. A total 177 with infection and 198 age- sex-matched healthy controls were enrolled in this study. We evaluated the urinary levels 8-oxo-7, 8-dihydro-2'deoxyguanosine (8-oxodGuo) 8-dihydroguanosine (8-oxoGuo) explored factors affecting 8-oxodGuo or 8-oxoGuo levels. Biomarkers liver function, cancer, inflammation determined. Nonparametric correlations used to evaluate correlation between various laboratory...
Objective To study the effects of Schwann cell-derived neurotrophic factor(SDNF) on myoblast stem cells(called satellite cells,SCs) in vitro. Methods After setting up SCs culture system vitro, which treated with various SDNF concentrations medium were dynamically evaluated by cell morphology,MTT growth curve and fusion rate. Results The ability preceding their participation muscle repair include proliferation differentiation, 200 ng/ml stimulated more than other medium,but 50 ng/ml,100...
Objective To evaluate the effect of five commonly used methods serologic test for diagnosis brucellosis and provide an effective practical serological detection scheme, to investigate significance serum agglutination (SAT) titer in assessing severity brucellosis. Methods The samples 137 patients with were collected as experimental group, while 78 non-brucella treated control group. The levels anti-Brucella two groups detected by rose bengal plate (RBPT), latex (LAT), (SAT), indirect...
Abstract Background: SARS-Coronavirus-2 (SARS-CoV-2), the pathogen of coronavirus disease 2019 (COVID-19), not only infects respiratory tract, but also other organs. About a third inpatients COVID-19 have neurological symptoms and in vitro experiments revealed that SARS-CoV-2 could infect human neural progenitor cells brain organoids. However, traditional test often reports negative owing to low number virus cerebrospinal fluid. To date, timely diagnosis central nervous system infection...