A5102898726- Pharmacological Receptor Mechanisms and Effects
- RNA Interference and Gene Delivery
- Immune cells in cancer
- Liver Disease Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Bipolar Disorder and Treatment
- Infectious Encephalopathies and Encephalitis
- Nanoplatforms for cancer theranostics
- Tryptophan and brain disorders
- Complementary and Alternative Medicine Studies
- Peroxisome Proliferator-Activated Receptors
- Streptococcal Infections and Treatments
- COVID-19 Clinical Research Studies
- Dental Research and COVID-19
- Inflammatory Biomarkers in Disease Prognosis
- Nosocomial Infections in ICU
- Civil and Geotechnical Engineering Research
- Burn Injury Management and Outcomes
- Cholinesterase and Neurodegenerative Diseases
- Cancer-related molecular mechanisms research
- Advanced biosensing and bioanalysis techniques
- Hepatocellular Carcinoma Treatment and Prognosis
- Phagocytosis and Immune Regulation
- Wound Healing and Treatments
- Alzheimer's disease research and treatments
Chongqing Medical University
2022-2025
Heilongjiang University of Chinese Medicine
2023-2025
National University of Malaysia
2024
Capital Medical University
2019-2022
Beijing Ditan Hospital
2020-2022
Jiangsu Hengrui Medicine (China)
2015-2021
Beijing YouAn Hospital
2019
University of Shanghai for Science and Technology
2010
In this globalization and information era, global uncertainties challenges are increasing. Moreover, there is a larger stage for countries to improve themselves. Media play crucial role in shaping country image, especially communicating better image. This study provides an overview of the research trends, key contributors, hotspots on image media from 2004 2023 through bibliometric analysis using VOSviewer, R-bibliometrix, Excel. Findings indicate that China United States lead research, with...
The nasopharyngeal microbiota is composed of a variety not only the true commensal bacterial species but also two-face pathobionts, which are one harmless and other highly invasive deadly pathogen. In previous study, we found that diversity was lost in severe influenza patients.
Chimeric antigen receptor T (CAR-T) cell therapy has faced a series of challenges and shown very little efficacy in solid tumors to date. Although genetically engineered macrophages have achieved definite therapeutic effect tumors, heterogeneous expression proteins the potential for toxicity limit further applications. Herein, we propose nongenetic simple macrophage engineering strategy through glycan metabolic labeling click reaction treatment tumors. The aptamer-engineered M1 (ApEn-M1)...
A novel series of imidazoisoindoles were identified as potent indoleamine-2,3-dioxygenase (IDO) inhibitors. Lead optimization toward improving potency and eliminating CYP inhibition resulted in the discovery lead compound 25, a highly IDO inhibitor with favorable pharmacokinetic properties. In MC38 xenograft model hPD-1 transgenic mice, 25 combination anti-PD-1 monoclonal antibody (SHR-1210) achieved synergistic antitumor effect superior to each single agent.
We reported that the complete genome sequence of SARS-Coronavirus-2 (SARS-CoV-2) was obtained from a cerebrospinal fluid (CSF) sample by ultrahigh-depth sequencing. Fourteen days after onset, seizures, maxillofacial convulsions, intractable hiccups and significant increase in intracranial pressure developed an adult coronavirus disease 2019 patient. The SARS-CoV-2 indicates can invade central nervous system. In future, along with system assessment, pathogen detection other indicators are...
The clinical significance of coexistence HBsAg/anti-HBs in chronic hepatitis B (CHB) patients remains controversial. This study was aimed to assess the association this serological pattern with hepatocellular carcinoma (HCC) CHB. In cross-section study, 206 CHB and HBsAg alone were included evaluate risk HCC development by logistic regression analysis. addition, a retrospective cohort 260 recruited estimate cumulative incidence Kaplan–Meier HBsAg/anti-HBs, high levels ("High") HBsAg/low...
The World Health Organization (WHO) declared the outbreak (COVID-19) is a pandemic on March 11, 2020. This study aims to explore how Sin Chew Daily and People's report China in this special period. Based five generic frames (Semetko &Valkenburg, 2000), identifies news used by each newspaper. findings present three topics of Sino-US political diplomacy, international politics Special region are most frequency two newspapers. For COVID-19 news, they emphasized anti-epidemic measures...
The World Health Organization (WHO) declared the outbreak (COVID-19) is a pandemic on March 11, 2020. This study aims to explore how Sin Chew Daily and People's report China in this special period. Based five generic frames (Semetko &Valkenburg, 2000), identifies news used by each newspaper. findings present three topics of Sino-US political diplomacy, international politics Special region are most frequency two newspapers. For COVID-19 news, they emphasized anti-epidemic measures...
In order to investigate the behaviors of support systems and associated ground deformations, centrifuge model test is adopted simulate excavation ultra-deep foundation pit in soft ground. this test, geometrical scale 1:120, soil layer thickness, depth retaining wall height are 60 cm, 31.6 cm 54.2 respectively. The consists two types soil, including silty clay sandy silt. aluminum alloy plate pipes used reinforced concrete diaphragm braces deformation, bending moment, brace axial force, earth...
In this study, a series of novel hydroxyamidine derivatives were identified as potent and selective IDO1 inhibitors by structure-based drug design. Among them, compounds 13-15 18 exhibited favorable enzymatic cellular activities. Compound showed improved bioavailability in mouse, rat, dog (F% = 44%, 58.8%, 102.1%, respectively). With reasonable vivo pharmacokinetic properties, compound was further evaluated transgenic MC38 xenograft mouse model. The combination with PD-1 monoclonal antibody...
Objective To investigate the effect of blue light in treating residual burn wounds. Methods Sixty-four massive burned patients with wounds (burn area 30%-80% total body surface and wound 0.5%-3%) treated between April 2013 October were allocated to control group (32 cases) treatment according random number table. In group, dressed povidone-iodine gauze. And, except for this, therapy. Between-group comparison was made on infection control, bacterial clearance rate, healing, healing...
Background/Aims: Hepatocellular carcinoma (HCC) is the fifth most common cancer in world and third leading cause of cancer-related death. Critical roles for long non-coding RNAs (lncRNAs) have recently been demonstrated a variety cancers, including hepatocellular carcinoma. However, effect mechanism lncRNAs in HCC tumorigenesis chemoresistance have not extensively characterized. Methods: In current study, we identified HCC-expressed lncRNA termed as HANR (HCC associated RNA). We by...
Abstract Background: SARS-Coronavirus-2 (SARS-CoV-2), the pathogen of coronavirus disease 2019 (COVID-19), not only infects respiratory tract, but also other organs. About a third inpatients COVID-19 have neurological symptoms and in vitro experiments revealed that SARS-CoV-2 could infect human neural progenitor cells brain organoids. However, traditional test often reports negative owing to low number virus cerebrospinal fluid. To date, timely diagnosis central nervous system infection...