A5100432151- MicroRNA in disease regulation
- Catalytic Processes in Materials Science
- Corneal surgery and disorders
- Computer Graphics and Visualization Techniques
- Catalysis and Oxidation Reactions
- Optical Systems and Laser Technology
- Glaucoma and retinal disorders
- Extracellular vesicles in disease
- Cytokine Signaling Pathways and Interactions
- 3D Shape Modeling and Analysis
- Cerebrovascular and Carotid Artery Diseases
- Ophthalmology and Visual Impairment Studies
- Autonomous Vehicle Technology and Safety
- Magnetic and transport properties of perovskites and related materials
- Neuroinflammation and Neurodegeneration Mechanisms
- Reconstructive Surgery and Microvascular Techniques
- interferon and immune responses
- Intraocular Surgery and Lenses
- Traffic control and management
- Medical Research and Treatments
- Chemokine receptors and signaling
- Multiple Myeloma Research and Treatments
- Vehicle emissions and performance
- Stochastic Gradient Optimization Techniques
- RNA Interference and Gene Delivery
Suzhou University of Science and Technology
2022-2025
Soochow University
2022-2025
First Affiliated Hospital of Soochow University
2022-2025
Nanjing Medical University
2021-2025
Tianjin Medical University
2021-2025
Second Hospital of Tianjin Medical University
2023-2025
Huawei Technologies (Sweden)
2024
First Affiliated Hospital of Henan University
2023-2024
University of Birmingham
2022-2024
Barrow Neurological Institute
2024
The proteolysis targeting chimera (PROTAC) strategy results in the down-regulation of unwanted protein(s) for disease treatment. In PROTAC process, a heterobifunctional degrader forms ternary complex with target protein interest (POI) and an E3 ligase, which ubiquitination proteasomal degradation POI. While formation is key attribute degraders, modification molecule to optimize can be labor-intensive tedious process. this study, we take advantage DNA-encoded library (DEL) technology...
In recent years, the development of BMSCs-derived exosomes (EXO) for treatment osteosarcoma (OS) is a safe and promising modality OS treatment, which can effectively deliver drugs to tumor cells in vivo. However, differences carried, binding EXOs other organs limit their therapeutic efficacy. Therefore, improving OS-targeting ability BMSCs developing new crucial clinical application targeted therapy OS.In this study, we constructed potential nano platform by modifying using bone-targeting...
With the rapid advancement of aerospace technology, maneuverability spacecraft has increasingly improved, creating a pressing demand for star sensors with high attitude update rate and precision. Star identification, as most complex time-consuming algorithm sensors, faces stringent requirements enhanced identification speed an rate. Furthermore, space environment is becoming more complex, need heightened detection sensitivity growing to facilitate real-time accurate alerts various...
Uncontrolled acute and persistent bleeding, as well with infection, is a great challenge because of the high mortality during treating patients injuries, complex surgery or bone marrow failure. Here, we develop an external form natural components which based on phosphorylated methacrylated gelatin (GelMA, G) cryogel (GP) loaded tannic acid (TA)-mixed copper ion (Cu2+) mesoporous bioactive glasses (MBG), named after GP@MBG-Cu-TA cryogel, to address goals reduce bleeding enhance antibacterial...
Open AccessCCS ChemistryRESEARCH ARTICLES6 Oct 2022Highly Emissive Luminogens in Both Solution and Aggregate States Pengbo Han, Guiquan Zhang, Jia Wang, Yejun Yao, Yanping Qiu, He Xu, Anjun Qin Ben Zhong Tang Han State Key Laboratory of Luminescent Materials Devices, Guangdong Provincial Luminescence from Molecular Aggregates, South China University Technology, Guangzhou 510640 Center for Aggregation-Induced Emission, AIE Institute, , Zhang Wang Yao Qiu Xu *Corresponding authors: E-mail...
Regulatory T cells (Tregs) display great promise in rheumatoid arthritis (RA) therapy. However, their low number and differentiation rate limit further application the clinics. In present study, we first optimized a combination of IL-2, TGF-β cyclin dependent kinase inhibitor AS2863619 (IL-2/TGF-β/AS), which could induce Tregs with high efficiency vitro. After induced (iTregs) were confirmed to suppress lymphocyte proliferation pro-inflammatory help (Th1 Th17) activation, chitosan-stabilized...
A hierarchical superhydrophobic Al-Li layered double hydroxide (LDH) films with different Li+/Al3+ molar ratios of 1:1, 1:2, 2:1, pH value 11.5 and reaction temperature 125 °C, have been fabricated on the surface Mg-5Li-1Al (LA51) alloys by hydrothermal method following characteristics controllable cation structure exchangeable anion between layers. The properties were investigated X-ray diffractometer (XRD), scanning electron microscope (SEM) energy dispersive spectrometer (EDS). XRD SEM...
Under the dual thrust of decarbonisation and digitalisation, data-driven enabling technologies become most promising solutions to reducing time, cost, effort required in development modern internal combustion engines (ICEs) which it is hard handle high-data-cost, high-dimensional, complex nonlinear modelling problems. This paper proposes a view used ICE soft sensors with focus on reduction experimental model complexity accelerate decarbonisation. The current progress ICEs briefly outlined...
This study aims to explore the regulatory role of cuproptosis in carotid intimal hyperplasia (IH), providing new insights into its pathophysiological mechanisms and potential diagnostic therapeutic strategies. Methods: We downloaded single-cell sequencing bulk transcriptome data from GEO database screen for copper-growth-associated genes (CAGs) using machine-learning algorithms, including Random Forest Support Vector Machine. After identifying relevant genes, we verified CAGs expression IH...
To evaluate the clinical efficacy and safety of posterior scleral contraction (PSC) in treatment myopic traction maculopathy (MTM) by three-dimensional magnetic resonance imaging (3D MRI), swept-source optical coherence tomography (SS-OCT) angiography (SS-OCTA). In this prospective study, 30 eyes 25 patients with MTM were treated PSC. The ocular parameters measured before surgery at 1 month, 6 months, year after 3D MRI SS-OCT/OCTA. differences preoperative postoperative parameters, including...
Given the increasing complexity of global supply chain, it is an important issue to enhance agilities enterprises that manufacture new energy materials reduce ripple effects chains. Quality function deployment (QFD) has been applied in many areas solve multi-criteria decision making (MCDM) problems successfully. However, there still lack sufficient research on use MCDM develop two house-of-quality systems chain manufacturing determine effect factors (REFs), agility indicators (SCAIs), and...
Purpose: To investigate induction of cell death in Osteosarcoma (OS) using the anti-tuberculosis drug, rifampicin, loaded into exosomes. Patients and Methods: BMSC-exosomes were isolated by ultracentrifugation ultrasonically with rifampicin. Nanoparticle exosome-rifampicin (EXO-RIF) was added to OS cell-lines, 143B MG63, vitro, observe growth inhibitory effect. In vivo experiments conducted injecting fluorescently labeled EXO-RIF through tail vein xenograft nude mice tracking distribution....
Abstract Aiming at the problem of low-dose computed tomography (LDCT) image quality degradation, this paper proposes a highly efficient encoder decoder CNN network(HEDCNN) based on multi-scale edge enhancement and dense connectivity. Firstly, The network uses feature learnable block to extract information original fuses it into all model through connectivity, which enhances ability recover information. Secondly, hybrid dilated convolution achieve receptive field coverage improve model's...
Animals and plants have numerous active protections for adapting to the complex severe living environments, providing endless inspiration extending service life of materials machines. Conch, a marine animal near coast chronically suffering from erosion sand in water, has adapted condition through its anti-erosion conch shell. Romanesco broccoli, plant whose inflorescence is self-similar character, natural fractal bud’s form. Coupling convex domes on shell structure novel valve core water...
Dedicated hybrid engine technology using auxiliary electronic components has been proven as an energy-saving solution to public concerns about energy consumption and carbon emissions. This paper proposes a generic approach of K-fold filter-collaborated feature selection (KFFC-FS) robustly identify the key parameters three performance indicators, i.e., volumetric efficiency, thermal fuel consumption. By this approach, five filters are collaborated provide robust rank importance avoid...
In clinical practice, the utilization of antibiotics is still main approach for treatment wound contamination, which lacks ability to accelerate healing and arises global concern antimicrobial resistance. Plenty alternative methods have been explored in recent years due fast development material science. Here, CuO/SiO2 nanowires (CuSi NWs) with good near-infrared (NIR) photothermal conversion are synthesized by a one-step hydrothermal method. The as-prepared CuSi NWs possess excellent...
Osteoporosis (OP) is a systemic skeletal disease characterized by reduced bone mass and degenerative microarchitecture. Apigenin (API), flavonoid derived mainly from celery, has been reported to be beneficial for the treatment of OP; however, underlying mechanisms remain unclear. Moreover, effects API on bone-forming cells, including mesenchymal stem cells osteoblasts, In present study, we first determined that could promote formation, improve metabolism in ovariectomized (OVX) mice,...