Wenkai Chen

ORCID: 0000-0001-5733-9185
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About
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Research Areas
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Traditional Chinese Medicine Studies
  • Legume Nitrogen Fixing Symbiosis
  • Signaling Pathways in Disease
  • Extracellular vesicles in disease
  • MicroRNA in disease regulation
  • Nematode management and characterization studies
  • Spinal Cord Injury Research
  • Alcohol Consumption and Health Effects
  • Soil Carbon and Nitrogen Dynamics
  • S100 Proteins and Annexins
  • Plant Stress Responses and Tolerance
  • Seedling growth and survival studies
  • Nanomaterials and Printing Technologies
  • Plant Water Relations and Carbon Dynamics
  • Non-Invasive Vital Sign Monitoring
  • Wound Healing and Treatments
  • Ultrasound and Hyperthermia Applications
  • Liver Disease Diagnosis and Treatment
  • Biofield Effects and Biophysics
  • Peroxisome Proliferator-Activated Receptors
  • Diet, Metabolism, and Disease
  • Ultrasound Imaging and Elastography
  • Quinazolinone synthesis and applications
  • Kidney Stones and Urolithiasis Treatments

Southern University of Science and Technology
2024-2025

Xiamen University
2022-2025

Southwest Jiaotong University
2022

Chengdu Institute of Biology
2017-2021

Chinese Academy of Sciences
2017-2021

University of Chinese Academy of Sciences
2021

Second Affiliated Hospital of Fujian Medical University
2019-2020

Fujian Medical University
2019-2020

Wenzhou Medical University
2019

First Affiliated Hospital of Wenzhou Medical University
2019

Phoebe zhennan (Gold Phoebe) is a threatened tree species in China and valuable important source of wood bioactive compounds used medicine. Apart from anthropogenic disturbances, several biotic constraints currently restrict its growth development. However, little attention has been given to building adaptive strategies for conservation by examining morphological physio-biochemical responses drought stress, the role fertilizers on these responses. A randomized experimental design was...

10.3389/fpls.2017.01561 article EN cc-by Frontiers in Plant Science 2017-09-13

Alnus cremastogyne, a broad-leaved tree endemic to south-western China, has both commercial and restoration importance. However, little is known of its morphological, physiological biochemical responses drought phosphorous (P) application. A randomized experimental design was used investigate how affected A. cremastogyne seedlings, the role that P applications play in these responses. Drought had significant negative effects on growth metabolism, as revealed by reduced biomass (leaf, shoot...

10.1038/s41598-018-24038-2 article EN cc-by Scientific Reports 2018-03-29

In recent years, the development of BMSCs-derived exosomes (EXO) for treatment osteosarcoma (OS) is a safe and promising modality OS treatment, which can effectively deliver drugs to tumor cells in vivo. However, differences carried, binding EXOs other organs limit their therapeutic efficacy. Therefore, improving OS-targeting ability BMSCs developing new crucial clinical application targeted therapy OS.In this study, we constructed potential nano platform by modifying using bone-targeting...

10.1186/s12951-023-02129-1 article EN cc-by Journal of Nanobiotechnology 2023-09-30

The generation and evaluation of a dielectric barrier discharge produced inside closed package made commercially available packaging film filled with gas mixtures Ar/CO2 at atmospheric pressure is reported. parameters were analysed by electrical measurements optical emission spectroscopy in two modes operation: trapped atmosphere flowing atmosphere. Gas temperature was estimated using the OH(A–X) spectrum rotational reached saturation level after few minutes plasma running. almost three...

10.1088/0963-0252/20/2/025008 article EN Plasma Sources Science and Technology 2011-02-28

Precise measurement of the blood flow velocity in major arteries is important for assessment circulation dysfunction but challenging when using a one-dimensional (1D) ultrasound transducer array. Current available velocimetry methods are susceptible to probe-to-vessel angle and require vessels be well-aligned within imaging plane 1D In this study, novel angle-independent (VT-vUS) based on speckle decorrelation analysis field signal proposed measure conventional We first introduced principle...

10.1109/tmi.2025.3529033 article EN IEEE Transactions on Medical Imaging 2025-01-01

Abstract Ultrasound velocimetry has been widely used for blood flow imaging. However, the measurements are constrained to resolve in‐plane 2D components when using a 1D transducer array. In this work, an ultrasound speckle decorrelation analysis‐based (3C‐vUS) is proposed 3D velocity measurement The 3C‐vUS theory first derived and validated with numerical simulations phantom experiments. in vivo testing results show that can accurately measure 3D‐velocity‐components of human carotid artery...

10.1002/advs.202401173 article EN cc-by Advanced Science 2024-06-20

Purpose: To investigate induction of cell death in Osteosarcoma (OS) using the anti-tuberculosis drug, rifampicin, loaded into exosomes. Patients and Methods: BMSC-exosomes were isolated by ultracentrifugation ultrasonically with rifampicin. Nanoparticle exosome-rifampicin (EXO-RIF) was added to OS cell-lines, 143B MG63, vitro, observe growth inhibitory effect. In vivo experiments conducted injecting fluorescently labeled EXO-RIF through tail vein xenograft nude mice tracking distribution....

10.2147/ijn.s379917 article EN cc-by-nc International Journal of Nanomedicine 2022-11-01

Abstract Soil water content and phosphorus availability are important factors that expected to shape soil microbiota. Although the impacts of deficit (drought) on microbiota have been reasonably studied, microbial responses P addition combined with rarely reported, especially in relation identity aboveground tree species. This study was conducted evaluate main interactive effects drought protozoa, communities as determined by phospholipids fatty acids ( PLFA s) enzyme activities a vegetated...

10.1002/ecs2.2276 article EN cc-by Ecosphere 2018-06-01

Summary The neuroinflammation following traumatic spinal cord injury (SCI) is a critical process that impacts both the and recovery of parenchyma. Infiltrating regulatory T (Treg) cells are potent anti‐inflammatory restrain post‐SCI neuroinflammation. To understand molecular mechanisms underlying activity infiltrating Treg cells, we used mouse compression model to analyze role Sirtuins (SIRTs) in modulation cell functions. We found expressions SIRT4 SIRT6 were up‐regulated cells. Using...

10.1111/imm.13123 article EN Immunology 2019-09-27

Abstract Background Spinal cord injury (SCI) triggers the primary mechanical and secondary inflammation-mediated injury. Neuroinflammation-mediated insult causes extensive neurological damage after SCI. Microglia play a pivotal role in initiation progression of post-SCI neuroinflammation. Methods To elucidate significance LRCH1 to microglial functions, we applied lentivirus-induced knockdown microglia culture tested microglia-mediated inflammatory reaction both vitro rat SCI model. Results...

10.1186/s12974-020-01884-4 article EN cc-by Journal of Neuroinflammation 2020-07-06

Abstract Agricultural management techniques such as mulching with crop straw can impact soil properties and may in turn change the structure function of food web. We investigated different types coverage levels on nematodes community walnut orchards. set up a randomized experimental design three mulch types, distance treatments plantation. The results indicated that number after was lower than found control (CK). However, metabolic footprints omnivore-predator showed higher values compared...

10.1038/s41598-020-72530-5 article EN cc-by Scientific Reports 2020-09-18

Abstract Straw mulching is an effective conservation tillage tool that utilizes waste resources and reduces environmental pollution. To determine the optimal levels of quality, placement quantity straw mulching, we performed a field experiment used Box–Behnken design combined with response surface methodology. The treatments designed for walnut saplings ( Juglans regia ) considered three independent variables: placement, mulching. Tree height (THW) net photosynthesis rate (NPR) were as...

10.1038/s41598-018-28345-6 article EN cc-by Scientific Reports 2018-06-27

Understanding phenotypic responses is crucial for predicting and managing the effects of environmental change on native species. Color display size are typically used to evaluate utilization value ornamental plants, which also important characters Lonicera nervosa Maxim. ( L. ). However, there limited documentation its floral adaptation. The conditions development an organism changes with altitudinal variation. aim this research was find flower trait variability maintenance tradeoff among...

10.3389/fevo.2021.719838 article EN cc-by Frontiers in Ecology and Evolution 2021-08-10
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