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Guangrong Ji

ORCID: 0000-0002-8299-6424
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About
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A5010318321
Research Areas
  • Extracellular vesicles in disease
  • RNA Interference and Gene Delivery
  • Synthesis and Catalytic Reactions
  • MicroRNA in disease regulation
  • Cancer therapeutics and mechanisms
  • Quinazolinone synthesis and applications

Union Hospital
 2024

Xiamen University
 2022

 Activation of Dynamin-Related Protein 1 and Induction of Mitochondrial Apoptosis by Exosome-Rifampicin Nanoparticles Exerts Anti-Osteosarcoma Effect
OPENALEX - Publications 
Wenkai Chen Wenping Lin Naichun Yu Linlin Zhang Zuoxing Wu and 11 more Yongjie Chen Zongguang Li Fengqing Gong Na Li Xiaohong Chen Xu He Yue Wu Xiangchen Zeng Yuting Yueh Ren Xu Guangrong Ji

Purpose: To investigate induction of cell death in Osteosarcoma (OS) using the anti-tuberculosis drug, rifampicin, loaded into exosomes. Patients and Methods: BMSC-exosomes were isolated by ultracentrifugation ultrasonically with rifampicin. Nanoparticle exosome-rifampicin (EXO-RIF) was added to OS cell-lines, 143B MG63, vitro, observe growth inhibitory effect. In vivo experiments conducted injecting fluorescently labeled EXO-RIF through tail vein xenograft nude mice tracking distribution....

10.2147/ijn.s379917 article EN cc-by-nc International Journal of Nanomedicine 2022-11-01
 Trifluoperazine exerts anti-osteosarcoma effect by inducing mitochondria-dependent apoptosis via AKT/TXNIP signaling pathway
OPENALEX - Publications 
Xiangchen Zeng Wenkai Chen Naichun Yu Zongguang Li Hongyu Li and 4 more Yongjie Chen Fengqing Gong Xing Jiang Guangrong Ji

10.1016/j.taap.2024.117080 article EN Toxicology and Applied Pharmacology 2024-08-30
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