A5008597130- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Liver Disease and Transplantation
- Liver physiology and pathology
- Circular RNAs in diseases
- Liver Diseases and Immunity
- Cancer, Lipids, and Metabolism
- Hepatitis B Virus Studies
- Organ Transplantation Techniques and Outcomes
- Alcohol Consumption and Health Effects
- Hepatocellular Carcinoma Treatment and Prognosis
- Extracellular vesicles in disease
- Mesenchymal stem cell research
- Immune Response and Inflammation
- Wnt/β-catenin signaling in development and cancer
- Advanced Photocatalysis Techniques
- Inflammatory Bowel Disease
- Cancer Genomics and Diagnostics
- Cancer-related gene regulation
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Diet and metabolism studies
Guangdong Provincial People's Hospital
2025
Guangdong Academy of Medical Sciences
2025
Southern Medical University
2025
Wenzhou Medical University
2013-2022
First Affiliated Hospital of Wenzhou Medical University
2013-2022
Affiliated Eye Hospital of Wenzhou Medical College
2022
Affiliated Hospital of Guangdong Medical College Hospital
2022
University of Michigan
1994
microRNA (miRNA) expression profiles varied greatly among current studies due to different technological platforms and small sample size. Systematic integrative analysis of published datesets that compared the miRNA between hepatocellular carcinoma (HCC) tissue paired adjacent noncancerous liver was performed determine candidate HCC associated miRNAs. Moreover, we further validated confirmed miRNAs in a clinical setting using qRT-PCR Tumor Cancer Genome Atlas (TCGA) dataset. A...
Hepatocellular carcinoma (HCC) is a highly heterogeneous disease, which makes the prognostic prediction challenging. As part of active cross-talk between tumor and host, inflammatory response in or its microenvironment could affect prognosis. However, value response-related genes HCC remains to be further elucidated.In this study, mRNA expression profiles corresponding clinical data patients were downloaded from public database. The least absolute shrinkage selection operator Cox analysis...
Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) has been reported to play a role in the suppression of activated hepatic stellate cells (HSCs). Moreover, it demonstrated that hypermethylation PTEN promoter is responsible for loss expression during HSC activation. Methylation now established as fundamental regulator gene transcription. MicroRNAs (miRNAs), which can control by binding their target genes degradation and/or translational repression, were found be involved liver...
Summary Long‐term prognosis varies widely among patients with hepatitis B virus ( HBV )‐related liver cirrhosis. Our study aimed to investigate the applicability of albumin‐bilirubin ALBI ), Child‐Pugh and model for end‐stage disease MELD ) scores long‐term prediction ‐related Patients diagnosed ‐associated cirrhosis from First Affiliated Hospital Wenzhou Medical University between January 2010 December 2015 were enrolled in this study. The followed up every 3 months. prognostic performance...
MicroRNA-223-3p (miR-223-3p) is one of the potential microRNAs that have been shown to alleviate inflammatory responses in pre-clinical investigations and highly encased exosomes derived from bone mesenchymal stem cells (MSC-exosomes). MSC-exosomes are able function as carriers deliver into cells. Autoimmune hepatitis challenging liver diseases with no effective treatment other than steroid hormones. Here, we examined whether can transfer miR-223-3p treat autoimmune an experimental model. We...
Summary Background Inflammation plays a vital role in liver cirrhosis progression and prognosis. Aim To investigate the prognostic significance of inflammatory response markers decompensated cirrhotic patients without acute‐on‐chronic failure ( ACLF ). Methods Independent predictors were identified using multivariate Cox model then assembled into nomogram to predict survival. Concordance index (C‐index) time‐dependent receiver operating characteristics (td‐ ROC ) analysis adopted evaluate...
Immunity plays an important role in tumor development. In this study, we aimed to investigate molecular classification and its prognostic value hepatocellular carcinoma (HCC) based on immune signature. Gene set enrichment analysis (GSEA) was used calculate scores of pathways for HCC hierarchical clustering two databases (The Cancer Genome Atlas [TCGA], Liver Cancer-RIKEN, JP [LIRI_JP]). The the microenvironment proportions 22 cells were also calculated. Single-sample GSEA (ssGSEA) screen...
// XiangJian Chen 1,* , KeQing Shi 2,* YuQun Wang 2 Mei Song Wu Zhou 3 HongXiang Tu and Zhuo Lin 1 Department of Endoscopic Surgery, The First Affiliated Hospital Wenzhou Medical University, Wenzhou, Zhejiang, China Infection Liver Diseases, Research Center, Laboratory, * These authors have contribute equally to this work Correspondence to: Lin, email: Keywords : colorectal cancer, microRNA, signature, biomarker, robust rank aggregation Received July 06, 2015 Accepted September 23, Published...
Gastric cancer (GC) is one of the most prevalent and lethal cancers worldwide. Ferroptosis a form iron-dependent regulated cell death emerging as promising strategy for therapy, whereas regulation mechanism remains unclear. WTX has been recognized potential tumor suppressor, but attempts at targeted therapy have not achieved substantial progress. Further research into structure, function, mechanisms urgently needed. Herein, we identified long isoform (WTX-L) potent ferroptosis effector in...
<title>Abstract</title> Gastric cancer (GC) metastasis remains a major cause of poor prognosis, yet its molecular drivers are poorly understood. Here, we integrated single-cell RNA sequencing (scRNA-seq) primary tumors and matched metastatic lymph nodes from six GC patients to identify epithelial subpopulation characterized by EGR4 overexpression. Kaplan-Meier analysis revealed that high expression correlated with reduced survival in patients. Mechanistically, chromatin immunoprecipitation...
microRNAs (miRNAs) have recently been reported to be involved in the progression of liver fibrosis. It has previously shown that miR-150 can inhibit activation hepatic stellate cells (HSCs) via inhibition C-myb expression. However, reduced expression is not responsible for all effects miR-150, there may other molecular mechanisms suppression HSCs by miR-150. In this study, gene array analysis was performed analyze miRNAs were differentially expressed between LX-2 induced transforming growth...
The thrombospondins (TSPs) are a growing family of cell surface and extracellular matrix molecules composed multiple repeating elements. Thrombospondin 3 is recently described member that possesses the calcium binding Type repeats, has 4 epidermal growth factor receptor-like 2 complete absence complement-like 1 distinct N terminus no significant homology to other TSPs. Metabolic labeling immunoprecipitation analysis cells transfected with TSP3 expression vector revealed it be an oligomeric...
Abstract Autoimmune hepatitis (AIH) is a chronic liver disease due to autoimmune system attacks hepatocytes and causes inflammation fibrosis. Intracellular signalling miRNA may play an important role in regulation of injury. This study aimed investigate the potential roles microRNA 143 murine AIH model hepatocyte injury model. Murine was induced by hepatic antigen S100, LPS. Mice AML12 cells were separated into six groups with or without treatment miRNA‐143. Inflammation fibrosis as well...
Hepatitis B virus (HBV) infection remains a major health problem and HBV-related-decompensated cirrhosis (HBV-DC) usually leads to poor prognosis. Our aim was determine the utility of inflammatory biomarkers in predicting mortality HBV-DC.A total 329 HBV-DC patients were enrolled. Survival estimates for entire study population generated using Kaplan-Meier method. The prognostic values model end-stage liver disease (MELD) score, Child-Pugh neutrophil/lymphocyte ratio, C-reactive...