A5113937856- RNA modifications and cancer
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Photosynthetic Processes and Mechanisms
- Mitochondrial Function and Pathology
- Natural product bioactivities and synthesis
- Cancer, Hypoxia, and Metabolism
- Liver Disease Diagnosis and Treatment
- Neuroscience and Neuropharmacology Research
- Circular RNAs in diseases
- CRISPR and Genetic Engineering
- Liver physiology and pathology
- Advanced biosensing and bioanalysis techniques
- Cancer-related gene regulation
- Plant Molecular Biology Research
- Viral Infectious Diseases and Gene Expression in Insects
- Phytochemistry and Biological Activities
- Cell death mechanisms and regulation
- Molecular Biology Techniques and Applications
- Glycosylation and Glycoproteins Research
- Insect Resistance and Genetics
- GABA and Rice Research
- Cancer Research and Treatments
- Plant tissue culture and regeneration
First Affiliated Hospital of Wenzhou Medical University
2016-2025
Wenzhou Medical University
2016-2025
Duke-NUS Medical School
2024
Gannan Normal University
2024
University of California, San Diego
2023
Shanghai Jiao Tong University
2008-2021
Jinshan Hospital of Fudan University
2014-2020
Dana-Farber Cancer Institute
2019
Songjiang District Central Hospital
2016-2019
Shanghai First People's Hospital
2016-2018
Abstract Background The triglyceride-glucose (TyG) index was significantly associated with insulin resistance (IR). Several studies have validated the effect of TyG on cerebrovascular disease. However, value in patients severe stroke requiring ICU admission remains unclear. aim this study to investigate association between and clinical prognosis critically ill ischemic (IS). Methods This identified IS from Medical Information Mart for Intensive Care (MIMIC-IV) database, divided them into...
Emerging evidence shows that Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) plays a pivotal role in cell proliferation, migration, and invasion tumors. However, the biological underlying mechanism of MALAT1 liver fibrosis remains undefined. In this study, up-regulation was observed fibrotic tissues activated hepatic stellate cells (HSCs). addition, depletion inhibited activation HSCs vitro attenuated collagen deposits vivo. Our results demonstrated expression is negatively...
Abstract Activation of hepatic stellate cells (HSCs), a pivotal event in liver fibrosis, is considered as an epithelial–mesenchymal transition (EMT) process. Deregulation long noncoding RNAs (lncRNAs) has been reported to be involved series human diseases. LncRNA-maternally expressed gene 3 (MEG3) functions tumor suppressor cancers and shown play vital role EMT However, the biological MEG3 fibrosis largely unknown. In this study, was reduced vivo vitro during fibrosis. Restoring expression...
Hepatocellular carcinoma (HCC) is a highly heterogeneous disease, which makes the prognostic prediction challenging. As part of active cross-talk between tumor and host, inflammatory response in or its microenvironment could affect prognosis. However, value response-related genes HCC remains to be further elucidated.In this study, mRNA expression profiles corresponding clinical data patients were downloaded from public database. The least absolute shrinkage selection operator Cox analysis...
Acetaminophen (APAP) overdose has long been considered a major cause of drug-induced liver injury. Ferroptosis is type programmed cell death mediated by iron-dependent lipid peroxidation. Endoplasmic reticulum (ER) stress systemic response triggered the accumulation unfolded or misfolded proteins in ER. and ER have proven to contribute progression APAP-induced acute injury (ALI). It was reported that salidroside protects against ALI, but potential mechanism remain unknown. In this study,...
Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) has been reported to play a role in the suppression of activated hepatic stellate cells (HSCs). Moreover, it demonstrated that hypermethylation PTEN promoter is responsible for loss expression during HSC activation. Methylation now established as fundamental regulator gene transcription. MicroRNAs (miRNAs), which can control by binding their target genes degradation and/or translational repression, were found be involved liver...
Abstract Epithelial‐mesenchymal transition ( EMT ) was reported to be involved in the activation of hepatic stellate cells HSC s), contributing development liver fibrosis. can promoted by Hedgehog (Hh) pathway. Patched1 PTCH 1), a negative regulatory factor Hh signalling pathway, down‐regulated during fibrosis and associated with its hypermethylation status. Micro RNA s (mi s) are play critical role control various functions. However, mi ‐mediated epigenetic regulations seldom studied. In...
Epithelial-mesenchymal transition (EMT) process is considered as a key event in the activation of hepatic stellate cells (HSCs). Hedgehog (Hh) pathway known to be required for EMT process. Long non-coding RNAs (lncRNAs) have been reported involved wide range biological processes. Plasmacytoma variant translocation 1 (PVT1), novel lncRNA, often up-regulated various human cancers. However, role PVT1 liver fibrosis remains undefined. In this study, was increased fibrotic tissues and activated...
Constitutive activation of Janus kinase 2/signal transducers and activators transcription (JAK2/STAT) signaling has an important role in the oncogenesis myeloproliferative neoplasms (MPNs) leukemia. Histone deacetylases (HDACs) inhibitors have been reported to possess anticancer activity through different mechanisms. However, whether HDACs suppress JAK2/STAT MPNs is still unknown. In this study, we show that HDAC inhibitor sodium butyrate (SB) inhibited increased expression suppressors...
Background/Aims: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic worldwide. Autophagy associated with NAFLD. Ghrelin a gut hormone various functions including energy metabolism and inflammation inhibition. We investigated therapeutic effect of ghrelin on NAFLD its association autophagy. Methods: C57bl/6 mice were fed high-fat diet for 8 weeks to induce model NAFLD, (10 µg/kg) administrated subcutaneously twice weekly from 6 8. LO2 cells pretreated (10-8 M) before...
// Fujun Yu 1,* , Zhongqiu Lu 2,* Kate Huang 3 Xiaodong Wang 1 Ziqiang Xu 4 Bicheng Chen 5 Peihong Dong and Jianjian Zheng Department of Infectious Diseases, The First Affiliated Hospital Wenzhou Medical University, Wenzhou, China 2 Emergency Department, Pathology, Institute Organ Transplantation, Key Laboratory Surgery, * These authors have contributed equally to this work Correspondence to: Zheng, email: Dong, Keywords : microRNA-17-5p, Wnt/β-catenin pathway, hepatic stellate cells,...
Ghrelin is a stomach-derived growth hormone secretagogue that promotes various physiological effects, including energy metabolism and amelioration of inflammation. The purpose this study was to investigate the protective mechanism ghrelin against liver fibrosis. Liver fibrosis induced in C57BL/6 mice by intraperitoneal injection CCl4 (2.0 mL/kg 10% v/v solution peanut oil) two times per week for eight weeks. (10 μg/kg) intraperitoneally injected A second murine model bile duct ligation (BDL)...
Abstract Circular RNAs (circRNAs), often dysregulated in a variety of human diseases, participate the initiation and development cancers. Recently, circMTO1 (a circRNA derived from MTO1 gene), identified as tumor suppressor, has been shown to contribute suppression hepatocellular carcinoma. The present study aimed explore clinical significance roles liver fibrosis. Here, we found that serum was significantly down‐regulated chronic hepatitis B (CHB) patients. Interestingly, negatively...