A5025569254- Inflammasome and immune disorders
- Hematopoietic Stem Cell Transplantation
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Biomarkers in Disease Mechanisms
- DNA Repair Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Ethics and Legal Issues in Pediatric Healthcare
- Epigenetics and DNA Methylation
- interferon and immune responses
- Cancer, Hypoxia, and Metabolism
- Immune cells in cancer
- Cancer-related gene regulation
- Language, Metaphor, and Cognition
- Syphilis Diagnosis and Treatment
- Virology and Viral Diseases
- Ginseng Biological Effects and Applications
- Muscle and Compartmental Disorders
- Reproductive tract infections research
- RNA modifications and cancer
- Acute Myeloid Leukemia Research
- Protein Tyrosine Phosphatases
- Cancer Cells and Metastasis
- Histone Deacetylase Inhibitors Research
Southern Medical University
2016-2024
Twelfth Guangzhou City People's Hospital
2018-2024
Hubei University of Chinese Medicine
2024
Nanfang Hospital
2016-2024
University of Pittsburgh
2021-2023
UPMC Hillman Cancer Center
2022-2023
Third Hospital of Hebei Medical University
2023
Hebei Medical University
2023
Hospital of Hebei Province
2023
University of Pittsburgh Medical Center
2022
Noncoding RNAs are emerging as important players in gene regulation and disease pathogeneses. Here, we show that a previously uncharacterized long noncoding RNA, nexilin F-actin binding protein antisense RNA 1 (NEXN-AS1), modulates the expression of actin-binding NEXN exerts protective role against atherosclerosis. An microarray analysis showed both NEXN-AS1 was reduced human atherosclerotic plaques. In vitro experiments revealed interacted with chromatin remodeler BAZ1A 5' flanking region...
Epithelial-mesenchymal transition (EMT) process is considered as a key event in the activation of hepatic stellate cells (HSCs). Hedgehog (Hh) pathway known to be required for EMT process. Long non-coding RNAs (lncRNAs) have been reported involved wide range biological processes. Plasmacytoma variant translocation 1 (PVT1), novel lncRNA, often up-regulated various human cancers. However, role PVT1 liver fibrosis remains undefined. In this study, was increased fibrotic tissues and activated...
Abstract The cross talk between extrinsic niche-derived and intrinsic hematopoietic stem cell (HSC) factors controlling HSC maintenance remains elusive. Here, we demonstrated that amphiregulin (AREG) from bone marrow (BM) leptin receptor (LepR+) niche cells is an important factor mediates the BM HSCs in maintenance. Mice deficient of DNA repair gene Brca2, specifically LepR+ (LepR-Cre;Brca2fl/fl), exhibited increased frequencies total myeloid-biased HSCs. Furthermore, LepR-Cre;Brca2fl/fl...
The side effects of current immunosuppressive drugs have impeded the development therapies for immune diseases. Selective regulation STAT signaling is an attractive strategy treating disorders. In this study, we used a small-molecule compound to explore possible means targeting STAT1 treatment Th1-mediated inflammation. in T cells from C57BL/6 mice was accomplished using fusaruside, that triggers tyrosine phosphorylation Src homology 2-containing protein phosphatase 2 (SHP-2). interaction...
Ginsenoside Rh2 (GRh2) and ginsenoside Rg3 (GRg3) are primary bioactive components in Panax ginseng. The present study aimed to investigate the underlying mechanisms of apoptotic cell‑death induced by GRh2 GRg3 human leukemia Jurkat cells. Cell Counting kit‑8 assay was used determine cell proliferation. Apoptosis detected nuclear morphologic observation Hoechst 33342 staining Annexin V-allophycocyanin 7-amino-actinomycin D assay. mitoTEMPO, a mitochondrial reactive oxygen species (ROS)...
Abstract The transcriptional repressor Hairy Enhancer of Split 1 (HES1) plays an essential role in the development many organs by promoting maintenance stem/progenitor cells, controlling reversibility cellular quiescence, and regulating both cell fate decisions. Deletion Hes1 mice results severe defects multiple is lethal late embryogenesis. Here we have investigated HES1 hematopoiesis using a hematopoietic lineage-specific knockout mouse model. We found that while dispensable for...
Summary The bone marrow ( BM ) microenvironment (niche) plays important roles in supporting normal/abnormal haematopoiesis. We investigated the interaction between leukaemic mesenchymal niche and haematopoietic stem progenitor cells HSPC s) using model of Fanconi anaemia FA ), a genetic disorder characterized by failure leukaemia. Healthy donor s co‐cultured on stromal MSC derived from patients with acute myeloid leukaemia AML exhibited higher human engraftment expansion Non‐obese diabetic...
A novel four-stage inertial microfluidic chip is developed for isolating rare circulating trophoblastic cells from whole blood samples of pregnancies. The antibody-free, low-cost assay may serve as a useful platform noninvasive prenatal testing.
Long non-coding RNAs (lncRNAs) are emerging as important players in gene regulation and cardiovascular diseases. However, the roles of lncRNAs atherosclerosis poorly understood. In present study, we found that levels NIPA1-SO were decreased while those NIPA1 increased human atherosclerotic plaques. Furthermore, negatively regulated expression umbilical vein endothelial cells (HUVECs). Mechanistically, interacted with transcription factor FUBP1 gene. The effect on protein was reversed by...
Abstract Acute compartment syndrome (ACS) is a severe orthopedic issue that, if left untreated, can result in lasting nerve and muscle damage or even necessitate amputation. The association between admission laboratory blood test indicators the occurrence of ACS patients with tibial diaphysis fractures currently subject debate. objective this research was to identify contributing factors for individuals suffering from fractures. In retrospective study, we collected data on total 705 our...
Plant-derived polysaccharide's conformation and chain structure play a key role in their various biological activities. Lycium barbarum L. leaves' polysaccharide is well renowned for its health functions. However, functional bioactivities are greatly hindered by compact globular high molecular weight. To overcome such issue to improve the of polysaccharides, degradation usually used modify polysaccharides conformation. In this study, ethanol extract containing crude was first extracted,...
Emerging evidence has shown that resting quiescent hematopoietic stem cells (HSCs) prefer to utilize anaerobic glycolysis rather than mitochondrial respiration for energy production. Compelling also revealed altered metabolic energetics in HSCs underlies the onset of certain blood diseases; however, mechanisms responsible energetic reprogramming remain elusive. We recently found Fanconi anemia (FA) their state are more dependent on metabolism glycolysis. In present study, we investigated...
Atherosclerosis is an immune inflammatory disease and a major cause of mortality morbidity worldwide. It generally considered that number potent proinflammatory cytokines have great influence on its pathogenesis, including IL-1β, IL-6, TNF-α, NF-κB. A growing amount empirical evidence indicates the mechanism cardiac dysfunction caused by lipopolysaccharide (LPS) activation inflammation, but exact in atherosclerosis still unclear. Previous studies shown interferon-induced protein with...
Ewing sarcoma (ES) of bone is accounting for the second most common type primary cancer in children and adolescents. However, patterns distant metastasis (DM) effect sites DM on survival outcomes were not investigated.This study aimed to investigate prognostic factors related metastatic ES bone.Patients who diagnosed with between 2010 2018 identified from Surveillance, Epidemiology, End Results database. Kaplan-Meier analysis, log-rank tests, Cox proportional-hazards regression models used...
The crosstalk between the BM microenvironment (niche) and hematopoietic stem cells (HSCs) is critical for HSC regeneration. Here, we show that in mice, deletion of Fanconi anemia (FA) genes Fanca Fancc dampened regeneration through direct effects on HSCs indirect niche cells. FA showed persistent upregulation Wnt target Prox1 response to total body irradiation (TBI). Accordingly, lineage-specific improved long-term repopulation irradiated HSCs. Forced expression WT mimicked defective...
The mortality rate of non-small-cell lung cancer (NSCLC) remains high worldwide. Although cisplatin-based chemotherapy may greatly enhance patient prognosis, resistance an obstacle to curing patients with NSCLC. Therefore, overcoming drug is the main route successful treatment, and combinatorial strategies have considerable clinical value in this effort. In study, we observed that both parthenolide (PTL) cisplatin (DDP) inhibited growth NSCLC cells a dose- time-dependent manner. combination...