A5100404323- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
- Lipid metabolism and disorders
- FOXO transcription factor regulation
- Circular RNAs in diseases
- Autophagy in Disease and Therapy
- interferon and immune responses
- Kruppel-like factors research
- MicroRNA in disease regulation
- melanin and skin pigmentation
- RNA regulation and disease
- Pancreatic function and diabetes
- Peroxisome Proliferator-Activated Receptors
- Microbial Metabolism and Applications
South China University of Technology
2025
Liuzhou Maternal and Child Health Hospital
2023
Guangzhou Medical University
2023
Guangzhou Women and Children Medical Center
2023
Peking University
2022
Peking University Cancer Hospital
2022
Dalian Medical University
2021
First Affiliated Hospital of Dalian Medical University
2021
Affiliated Hospital of Qingdao University
2018
Qingdao University
2018
Pancreatic ductal adenocarcinoma (PDAC) remains a highly lethal malignancy with limited treatment options. Investigating novel therapeutic targets and understanding mechanisms of chemoresistance are crucial for improving patient outcomes. This study investigated the role CKS1B in PDAC carcinogenesis, stemness chemoresistance, explores underlying driving its upregulation. The findings may provide insights potential strategies PDAC. Methods: expression was analyzed tissues cell lines, impact...
Long non-coding RNAs (lncRNAs) are emerging as important players in gene regulation and cardiovascular diseases. However, the roles of lncRNAs atherosclerosis poorly understood. In present study, we found that levels NIPA1-SO were decreased while those NIPA1 increased human atherosclerotic plaques. Furthermore, negatively regulated expression umbilical vein endothelial cells (HUVECs). Mechanistically, interacted with transcription factor FUBP1 gene. The effect on protein was reversed by...
Abstract We previously reported that three point mutations in SASH 1 and mutated promote melanocyte migration dyschromatosis universalis hereditaria ( DUH ) a novel p53/ POMC /Gαs/ autoregulatory positive feedback loop is regulated by to induce pathological hyperpigmentation phenotype. However, the underlying mechanism of molecular regulation cause this disorder still remains unclear. In study, we aimed investigate undergirding disorder. Our results revealed binds with MAP 2K2 induced p53‐ ‐...
Abstract Emerging evidence suggests that long noncoding RNAs (lncRNAs) are involved in many biological processes, such as cell growth, differentiation, apoptosis, and autophagy. Metastasis‐associated lung adenocarcinoma transcript 1 (MALAT1), highly expressed endothelial cells, is well conserved implicated migration proliferation. However, whether MALAT1 participates oxidized low‐density lipoprotein (ox‐LDL)‐induced autophagy regulation human umbilical vein cells (HUVECs) remains unknown. In...
Brain glioblastoma multiforme (GBM) is the most common primary malignant intracranial tumor. The prognosis of this disease extremely poor. While introduction β-interferon (IFN-β) regimen in treatment gliomas has significantly improved outcome patients; mechanism by which IFN-β induces increased TMZ sensitivity not been described. Therefore, main objective study was to elucidate molecular mechanisms responsible for beneficial effect IFNβ GBM.Messenger RNA expression profiles and...
Osteosarcoma (OS) is a high-grade, aggressive bone sarcoma. LncRNAs play key regulatory role in controlling biological and pathological processes. The expression of lncRNA SNHG9 varies among different cancer tissues, the OS progression unclear. In this study, we found overexpression tissues cells. addition, downregulated impaired proliferation, migration, invasion abilities was positively regulated by transcription factor SOX4. interacted with miR-214-5p as molecular sponge SOX4 identified...
Abstract Background: Brain glioblastoma (GBM) is the most common primary malignant tumor of intracranial tumors. The prognosis this disease extremely poor. While introduction IFN-β regimen in treatment gliomas has significantly improved outcome patients, underlying mechanism remains to be elucidated. Materials and methods: mRNA expression profiles clinicopathological data were downloaded from TCGA-GBM GSE83300 set GEO. Univariate Cox regression analysis lasso model established a novel...