A5061122874- Cancer-related molecular mechanisms research
- Atherosclerosis and Cardiovascular Diseases
- Wnt/β-catenin signaling in development and cancer
- Lipid metabolism and disorders
- RNA Research and Splicing
- Corneal surgery and disorders
- Antioxidant Activity and Oxidative Stress
- RNA modifications and cancer
- Cell Adhesion Molecules Research
Guangzhou Medical University
2022-2023
Guangzhou Women and Children Medical Center
2022-2023
Increasing evidence suggests that long noncoding RNAs play significant roles in vascular biology and disease development. One such RNA,
Long non-coding RNAs (lncRNAs) are emerging as important players in gene regulation and cardiovascular diseases. However, the roles of lncRNAs atherosclerosis poorly understood. In present study, we found that levels NIPA1-SO were decreased while those NIPA1 increased human atherosclerotic plaques. Furthermore, negatively regulated expression umbilical vein endothelial cells (HUVECs). Mechanistically, interacted with transcription factor FUBP1 gene. The effect on protein was reversed by...
Yippee-like 2 (YPEL2) is expressed in tissues and organs enriched vascular networks, such as heart, kidney, lung. However, the roles of YPEL2 endothelial cell senescence expression atherosclerotic plaques have not yet been investigated. Here, we report essential role promoting human umbilical vein cells (HUVECs) upregulation plaques. was significantly upregulated both H2O2-induced senescent HUVECs arteries aged mice. Endothelial deficiency decreased H2O2-increased senescence-associated...