A5100372225- Mesenchymal stem cell research
- Pancreatic function and diabetes
- Glioma Diagnosis and Treatment
- MicroRNA in disease regulation
- Wnt/β-catenin signaling in development and cancer
- Oral microbiology and periodontitis research
- Graphene and Nanomaterials Applications
- Fullerene Chemistry and Applications
- Tissue Engineering and Regenerative Medicine
- Extracellular vesicles in disease
- Chronic Lymphocytic Leukemia Research
- Cancer-related molecular mechanisms research
- Nanoparticle-Based Drug Delivery
- Cancer-related gene regulation
- Magnetic properties of thin films
- Ferroptosis and cancer prognosis
- Dental Erosion and Treatment
- Developmental Biology and Gene Regulation
- RNA Interference and Gene Delivery
- Phagocytosis and Immune Regulation
- Cell death mechanisms and regulation
- Retinoids in leukemia and cellular processes
- Fluoride Effects and Removal
- Medicinal Plants and Bioactive Compounds
- Infectious Aortic and Vascular Conditions
Seoul National University Hospital
2022-2025
Seoul National University
2022-2025
Jiangnan University
2021-2025
Northeast Forestry University
2025
Henan Cancer Hospital
2025
Zhengzhou University
2025
China Pharmaceutical University
2018-2025
Institute of Physics
2022-2024
Chinese Academy of Sciences
2014-2024
University of Chinese Academy of Sciences
2014-2024
Dlx homeobox genes are mammalian homologs of the Drosophila Distal-less ( Dll ) gene. The / gene family is ancient origin and appears to play a role in appendage development essentially all species which it has been identified. In , expressed distal portion developing appendages critical for structures. addition, human Dlx5 Dlx6 have identified as possible candidate autosomal dominant form split-hand/split-foot malformation (SHFM), heterogeneous limb disorder characterized by missing central...
Mesenchymal stem cells (MSCs) have been widely proven effective for therapeutic angiogenesis in ischemia animal models as well clinical vascular diseases. Because of the invasive method, limited resources, and aging problems adult tissue-derived MSCs, more perinatal MSCs isolated studied promising substitutable cell transplantation. However, fewer studies comparatively angiogenic efficacy derived from different tissues sources. Here, we evaluated whether in-situ environment would affect...
The incretin glucagon-like peptide-1 (GLP-1)-(7---36) amide is an important factor in prandial glucose homeostasis. Findings that GLP-1 rapidly inactivated led to the hypothesis target of close site release. To investigate whether tissue located hepatoportal system, we administered with into portal vein rats and compared this peripheral administration (jugular vein) studied effects blockers nervous system. Portal augmented insulin response a bolus by 81% (P < 0.01) markedly improved disposal...
Abstract Introduction Mesenchymal stem cells (MSCs) represent a heterogeneous cell population that is promising for regenerative medicine. The present study was designed to assess whether VCAM-1 can be used as marker of MSC subpopulation with superior angiogenic potential. Methods MSCs were isolated from placenta chorionic villi (CV). +/− CV-MSCs separated by Flow Cytometry and subjected comparative analysis their properties including genes expression, vasculo-angiogenic abilities on...
The search for materials that exhibit topologically protected spin configurations, such as magnetic skyrmions, continues to be fueled by the promise of outstanding candidate components spin-based applications. In this study, in situ Lorentz transmission electron microscopy directly images Bloch-type skyrmionic bubbles a layered ferromagnet Cr0.87Te single crystal. Owing competition between dipole interaction and uniaxial easy axis anisotropy, nanoscale with random chirality can observed wide...
The recent discoveries of surperisingly large anomalous Hall effect in chiral antiderromagnets have triggered extensive research efforts various fields, ranging from topological condensed-matter physics to antiferromagnetic spintronics, and energy harvesting technology. However, such AHE-hosting materials are rare nature. Herein, we demonstrate that Mn2.4Ga, a Fermi-level-tuned kagome antiferromagnet, has conductivity about 150 {\Omega}-1cm-1 at room temperature surpasses the usual high...
Fibroblast activation protein (FAP) has emerged as a prominent target for tumor diagnosis. Quinoline-based FAP PET tracers demonstrated clinical feasibility. However, there is relative scarcity of studies on 99mTc-labeled SPECT tracers. The existing quinoline-derived 99mTc-FAPI tracer exhibits relatively low uptake and suboptimal pharmacokinetic properties, which restrict its application. Consequently, it necessary to alter the pharmacophores improve druggability. In this study, novel...
Mesenchymal stem cells (MSCs) have been utilized in treating acute graft-versus-host disease (aGvHD) as they show strong immunosuppressive capacity through the release of various mediators, including molecules, growth factors, chemokines, and exosomes. MicroRNAs (miRNAs) derived from MSC exosomes (MSCs-Exo) play a critical role regulation immune responses. However, function miRNAs aGvHD remains unknown. Here, we performed expression profiling exosome-miRNAs human umbilical cord MSCs...
Background Recently, immunotherapy with immune checkpoint inhibitors (ICIs) has shown promising efficacy in biliary tract cancer (BTC), which includes gallbladder (GBC) and cholangiocarcinoma (CHOL). Understanding the association between outcomes genomic profile of advanced BTC may further improve clinical benefits from immunotherapy. Methods Genomic tumor DNA was isolated 98 Chinese patients used for targeted next-generation sequencing 416 cancer-related genes to identify alterations common...
Helicobacter pylori infection induces a number of pro-inflammatory signaling pathways contributing to gastric inflammation and carcinogenesis has been identified as major risk factor for the development cancer (GC). Janus kinase-signal transducer activator transcription (JAK-STAT) mediates immune regulatory processes, including tumor-driven escape. Programmed death ligand 1 (PD-L1) expressed on epithelium can suppress system by shutting down T cell effector function. In human cohort subjects...
Localized intestine inflammation could induce short-term increases in colonic oxygenation and leads to the aerobic bacteria population reduction anaerobic by changing intestinal environment. However, mechanisms involved associated functions of anaerobes gut health still remain unclear. Here, we found that early-life depletion microbiota exacerbated later colitis, while mid-life showed partially reduced colitis. Notably, observed confers susceptibility ferroptosis In contrast, restitution...
Mesenchymal stem cells (MSCs) do not readily migrate to appropriate sites, and this creates a major obstacle for their use in the treatment of graft-versus-host disease (GVHD). Intercellular adhesion molecule-1 (ICAM-1) can guide homing various immune proper anatomical location within secondary lymphoid organs (SLOs), which are niches generating responses or tolerance. MSCs rarely SLOs after intravenous infusion, constitutively low expression ICAM-1. So our previous work, ICAM-1 was...
Although emerging evidence links mesenchymal stem cells (MSCs) with cancer metastasis, the underlying mechanisms are poorly understood. In present study, we found that human umbilical cord-derived MSCs (UC-MSCs) promoted MCF-7 cell migration in vitro and metastasis vivo. To explore mechanisms, characteristics of cocultured UC-MSCs were assessed. The expression secretion interleukin-8 (IL-8) IL-6 induced UC-MSCs. However, neutralization IL-8 or secreted by could attenuate enhanced UC-MSCs,...
Closed-loop glucose-responsive insulin delivery with excellent biocompatibility has the potential to improve health and quality of life diabetic patients. Herein, we developed an system using a pH-sensitive peptide hydrogel loaded glucose-specific enzyme. The designed can be used as carrier that is enzyme via self-assembly process under physiological conditions. When hyperglycemia encountered, enzymatic conversion glucose into gluconic acid leads decrease in local pH, disassembled because...
MicroRNA (miR)-150-5p has been investigated in many studies, while the role of exosomal miR-150-5p from bone arrow mesenchymal stromal cells (BMSCs) on cerebral ischemia/reperfusion (I/R) injury is not fully explored. This research aims to probe effects BMSCs I/R via regulating B-cell translocation gene 2 (TLR5). Bone marrow stem cell-derived exosomes (BMSCs-Exo) were isolated and identified. The middle artery occlusion (MCAO) rat model was established treated by BMSCs-Exo. Then, functional...
Prenylated flavonoids have been demonstrated to possess diverse bioactivities including antitumor effects. One new, daphnegiravone D (1), and four known (2-5) prenylated were isolated from Daphne giraldii. Their cytotoxic activities revealed that markedly inhibited the proliferation of cancer cells, but had no apparent cytotoxicity on human normal cells. Mechanistically, induced G0/G1 arrest apoptosis, reduced expression cyclin E1, CDK2 CDK4, promoted cleavage caspase 3 PARP in Hep3B HepG2...
Antibiotic resistance is the most important factor leading to failed Helicobacter pylori eradication therapy, and personalized treatment based on antibiotic susceptibility becoming increasingly important. To strengthen understanding of genotypic H. identify new loci, in this study, we identified phenotypic information for 60 clinical isolates compared concordance using whole-genome sequencing (WGS). Clarithromycin levofloxacin was almost perfect with resistance, kappa coefficients 0.867...
Purpose This study aims to explore a methodology based on the Kano model. And use this method determine user requirement attributes in field of school uniform customization. To construct set processes that can be used as reference for constructing clothing customization platform. Design/methodology/approach An optimized quantitative model was applied. Initially, survey conducted assess current market customized uniforms China. Subsequently, attribute questionnaire developed, and experts from...
Abstract Polyoxometalates (POM) are a class of inorganic metal oxides with distinctive structural characteristics, compositional versatility, high catalytic efficacy, and convenient storage properties. In recent years, POM have shown considerable potential for mimicking enzyme activities. Besides their biological activities, been demonstrated to possess the ability sense diseases perform synergistic therapies based on redox near‐infrared absorption Similar metallic nanoparticles organic...