A5001547762- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Research Studies
- MicroRNA in disease regulation
- CAR-T cell therapy research
- Bioactive Natural Diterpenoids Research
- Neuroscience and Neuropharmacology Research
- RNA modifications and cancer
- Cerebrospinal fluid and hydrocephalus
- Lung Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Traumatic Brain Injury and Neurovascular Disturbances
- Epigenetics and DNA Methylation
- Receptor Mechanisms and Signaling
- Peptidase Inhibition and Analysis
- Circular RNAs in diseases
- Gastric Cancer Management and Outcomes
- Molecular Biology Techniques and Applications
- PI3K/AKT/mTOR signaling in cancer
- Ferroptosis and cancer prognosis
- Endoplasmic Reticulum Stress and Disease
Tianjin Medical University Cancer Institute and Hospital
2016-2025
East China Normal University
2025
University of Science and Technology of China
2025
Sun Yat-sen University
2025
Tianjin University of Sport
2025
Tianjin Medical University
2012-2024
Harbin Medical University
2011-2024
Tianjin haihe hospital
2023-2024
First Affiliated Hospital of Bengbu Medical College
2014-2024
Henan Provincial Chest Hospital
2019-2024
Mitochondrial DNA (mtDNA) mutations have been found in many cancers but the physiological derangements caused by such remained elusive. Prostate cancer is associated with both inherited and somatic cytochrome c oxidase (COI) gene. We present a prostate patient-derived rare heteroplasmic mutation of this gene, part mitochondrial respiratory complex IV. Functional studies indicate that leads to simultaneous decrease oxidation, increase reactive oxygen, increased nitrogen. These data suggest...
We show that glymphatic influx into the brain occurs in direct proportion to slow cortical activity and inversely heart rate.
Abstract Background The glymphatic pathway transports cerebrospinal fluid through the brain, thereby facilitating waste removal. A unique aspect of this is that its function depends on state consciousness brain and associated with norepinephrine activity. current view all anesthetics will increase transport by inducing unconsciousness. This implies effect should be independent their mechanism action, as long they induce We tested hypothesis comparing supplementary dexmedetomidine, which...
Importance Adjuvant and neoadjuvant immunotherapy have improved clinical outcomes for patients with early-stage non–small cell lung cancer (NSCLC). However, the optimal combination of checkpoint inhibition chemotherapy remains unknown. Objective To determine whether toripalimab in platinum-based will improve event-free survival major pathological response stage II or III resectable NSCLC compared alone. Design, Setting, Participants This randomized trial enrolled (without EGFR ALK...
Progressive neuronal loss is a hallmark feature distinguishing neurodegenerative diseases from normal ageing. However, the underlying mechanisms remain unknown. Extracellular K+ homeostasis potential mediator of injury as elevations increase excitatory activity. The dysregulation extracellular and potassium channel expressions during neurodegeneration could contribute to this distinction. Here we measured cortical concentration ([K+]e) in awake wild-type mice well murine models using...
The receptor tyrosine kinase/PI3K/AKT/mammalian target of rapamycin (RTK/PI3K/AKT/mTOR) pathway is frequently altered in cancer, but the underlying mechanism leading to tumorigenesis by activated mTOR remains less clear. Here we show that a positive regulator Notch signaling mouse and human cells, acting through induction STAT3/p63/Jagged cascade. Furthermore, response differential cues from mTOR, found served as molecular switch shift balance between cell proliferation differentiation. We...
Tumor cell-derived extracellular vesicles (EV) convert normal myeloid cells into myeloid-derived suppressor (MDSC), inhibiting antitumor immune responses. Here, we show that EV from Ret mouse melanoma upregulate the expression of programmed cell death ligand 1 (PD-L1) on immature (IMC), leading to suppression T-cell activation. PD-L1 and immunosuppressive potential EV-generated MDSC were dependent Toll-like receptors (TLR). IMC Tlr4-/- mice failed increase immunosuppression with Ret-EV...
Natural killer (NK) cells are important in host to eliminate circulating tumour (CTCs) turn preventing the development of into metastasis but mechanisms very poorly defined. Here we find that expression level miR-296-3p is much lower non-metastatic human prostate cancer (PCa) cell line P69 than highly metastatic M12, which derived from P69. We demonstrate directly targets and inhibits intercellular adhesion molecule 1 (ICAM-1) malignant M12. The data clinical tissue microarrays also show...
The emerging interest in brain fluid transport has prompted a need for techniques that provide an understanding of what factors regulate cerebrospinal (CSF) production. Here, we describe methodology direct quantification CSF production awake mice. We measure by placing catheter lateral ventricle, while physically blocking outflow from the 4th ventricle. Using this methodology, show increases during isoflurane anesthesia, and to lesser extent with ketamine/xylazine relative state. Aged mice...
Accumulating evidence indicates that a small subset of cancer cells, termed the tumor-initiating cells or stem (CSCs), construct reservoir self-sustaining with characteristic ability to self-renew and maintain tumor mass. The CSCs play an important role in initiation, development, relapse, metastasis, ineffectiveness conventional therapies. CD47 is ligand for signal-regulatory protein-α expressed on phagocytic functions inhibit phagocytosis. This study was explore if expression mechanism...
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of myeloid that suppress T-cell activity in tumor microenvironment. However, the suppressive function MDSCs on B and its underlying mechanism remain unclear. Here, we show 4T1 breast cancer mice, significantly increased number MDSCs, parallel with splenic cells, accumulated when compared to normal mice. In presence surface molecules remolded, checkpoint-related such as PD-1 PD-L1 changing prominently. also emerge vital...
Highlights•Behavioral state transitions is paralleled by a cortex-wide increase in [K+]o•Increased [K+]o depolarizes cortical neurons and amplifies their excitability vitro•State-dependent visual gain modulation recreated local changes [K+]o•Increasing motor enhances L5 spiking improves performanceSummaryBrain fluctuations modulate sensory processing, but the factors governing state-dependent neural activity remain unclear. Here, we tracked dynamics of extracellular K+ concentrations ([K+]o)...
As a hallmark of cancer, the Warburg effect (aerobic glycolysis) confers selective advantage for survival and proliferation cancer cells. Due to frequent aberration upstream proto-oncogenes tumor suppressors, hyperactive mammalian/mechanistic target rapamycin (mTOR) is potent inducer effect. Here, we report that overexpression glycolytic enzyme, phosphoglyceric acid mutase-1 (PGAM1), critical oncogenic mTOR-mediated mTOR stimulated PGAM1 expression through hypoxia-inducible factor...
•Polymeric micellar paclitaxel is a significant breakthrough in the history of chemotherapy.•Polymeric yielded superior objective response rate compared with solvent-based paclitaxel.•Polymeric progression-free survival lower incidence treatment-related serious adverse events should be preferred over first-line treatment advanced non-small-cell lung cancer. BackgroundPolymeric (pm-Pac) novel Cremophor EL-free, nanoparticle formulation paclitaxel. We aimed to compare efficacy and safety...
Abstract Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of myeloid that closely related to tumor immune escape, but the mechanism by which MDSCs regulate B has not been elucidated. Our previous studies revealed breast cancer-derived could induce PD-1 − PD-L1 + Bregs with immunosuppressive functions. Here, we reported blocking PD-1/PD-L1 interaction between and reverse functions Bregs. The activation PI3K/AKT/NF-κB signaling pathway is essential for exert effects....
Abstract As a widely studied adoptive treatment method, CIK (cytokine-induced killer cells) has shown clinical benefits in many trials on non-small cell lung cancer. heterogeneous population, however, cells have strong instability and individual differences their efficacies, which are collaboratively regulated by the tumor microenvironment subpopulations. Among them, CD4 + T belong to crucial subgroup of influence therapy is still unclear. Herein, we show how positively regulate functions...
// Qian Sun 1 , Haiyue Zhao Cong Zhang Ting Hu Jianli Wu Xingguang Lin Danfeng Luo Changyu Wang Li Meng Ling Xi Kezhen Junbo Ding Ma and Tao Zhu Cancer Biology Research Center, Key Laboratory of the Ministry Education, Tongji Hospital, Medical College, Huazhong University Science Technology, Wuhan, People's Republic China Correspondence to: Zhu, email: zhutao@tjh.tjmu.edu.cn Keywords: ovarian cancer, WGCNA, gene co-expression network, grade, stage Received: October 13, 2016 Accepted: April...