A5101762702- Neonatal Respiratory Health Research
- Cardiac electrophysiology and arrhythmias
- Alzheimer's disease research and treatments
- Hip and Femur Fractures
- Neuroscience and Neural Engineering
- Congenital Diaphragmatic Hernia Studies
- Lung Cancer Treatments and Mutations
- Influenza Virus Research Studies
- Pancreatitis Pathology and Treatment
- Blood Pressure and Hypertension Studies
- Laser Applications in Dentistry and Medicine
- Orthopaedic implants and arthroplasty
- Sirtuins and Resveratrol in Medicine
- Nerve injury and regeneration
- Lung Cancer Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Neuroscience of respiration and sleep
- Total Knee Arthroplasty Outcomes
- Esophageal Cancer Research and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Pulmonary Hypertension Research and Treatments
- Lung Cancer Research Studies
- Epigenetics and DNA Methylation
- Pancreatic and Hepatic Oncology Research
- Spinal Cord Injury Research
China Pharmaceutical University
2022-2025
China Agricultural University
2025
Taizhou Central Hospital
2019-2025
Taizhou University
2019-2025
Zhengzhou Central Hospital
2024
Liaocheng People's Hospital
2024
Guangzhou University of Chinese Medicine
2024
University Medical Centre Mannheim
2021-2023
Heidelberg University
2021-2023
Tokushima University
2023
To assess the prevalence, awareness, treatment, and control of hypertension their associated factors in an urban Chinese population.A cross-sectional study was conducted three cities northeast China from 2009 to 2010, using a multistage cluster sampling method select representative sample. A total 25 196 adults, aged 18-74 years, were examined 33 communities. Hypertension defined as mean SBP at least 140 mmHg, DBP 90 and/or use antihypertensive medications.Overall, prevalence 28.7% for...
An increase in interleukin (IL)-17A-producing cells, particularly at sites of tissue inflammation, is observed frequently, yet the mechanism not fully understood. This study aims to dissect role IL-17 autoimmunity-mediated neuroinflammation. The cytokine milieu containing elevated IL-17, which often appears active states autoimmunity, was mimicked vitro by a supernatant obtained from rat peripheral blood monocytes stimulated with phorbol mystistate acetate (PMA)/ionomycin. application such...
Background Computed tomography (CT) or MR images may cause the severity of early acute pancreatitis (AP) to be underestimated. As an innovative image analysis method, radiomics have potential clinical value in prediction AP severity. Purpose To develop a contrast‐enhanced (CE) MRI‐based model for Study Type Retrospective. Subjects A total 259 patients were divided into two cohorts, training cohort (99 nonsevere, 81 severe), and validation (43 36 severe). Field Strength/Sequence 3.0T, T 1...
Abstract Macrophages play key roles in the secondary injury stage of spinal cord (SCI). M1 macrophages occupy lesion area and secrete high levels inflammatory factors that hinder repair, M2 can neurotrophic promote axonal regeneration. The regulation macrophage secretion after SCI is critical for repair. Low‐level laser therapy (810‐nm) (LLLT) boost functional rehabilitation rats SCI; however, mechanisms remain unclear. To explore this issue, we established an vitro model low‐level...
Dendritic cells (DCs) are crucial for the initiation and regulation of innate adaptive immunity. Their maturity infiltration in tumor largely determine efficiency antigen presentation, CTL responses, prognosis tumors. However, application common immunoregulatory plant polysaccharides to DCs vivo still represents major challenges due off-target effect short biological lifespan. Lonicera japonica Thunb. (LJP) were found exert benign ability, but effectiveness utilizing LJP alone is...
Fibroblast activation protein (FAP) has emerged as a prominent target for tumor diagnosis. Quinoline-based FAP PET tracers demonstrated clinical feasibility. However, there is relative scarcity of studies on 99mTc-labeled SPECT tracers. The existing quinoline-derived 99mTc-FAPI tracer exhibits relatively low uptake and suboptimal pharmacokinetic properties, which restrict its application. Consequently, it necessary to alter the pharmacophores improve druggability. In this study, novel...
Few studies have investigated the association between carotid artery napkin-ring sign (NRS) and cerebral small vessel disease (CSVD). This study aimed to investigate whether NRS plaque burden CSVD are associated. retrospective, single-center, cross-sectional following STROBE guidelines enrolled patients with symptoms or clinical suspicion of anterior circulation acute ischemic stroke (AIS). Plaques were evaluated using preoperative cervicocerebral computed tomography angiography (CTA)....
Background Bronchopulmonary dysplasia (BPD) is a major threat to the health of premature infants yet its pathogenesis not fully understood. Epithelial-mesenchymal transition (EMT) lung epithelial cells may lead BPD. Objective To investigate potential occurrence EMT in newborn rat model Methods Newborn rats were exposed hyperoxic environment within 12 hr birth. Lung tissue and isolated alveolar type II (AT2 cells) collected on Days 1, 3, 7, 14, 21 after exposure. Pathological changes tissue,...
Apolipoprotein is genetically associated with the risk of Alzheimer's disease (AD). The APOA1, APOC3, and APOA4 genes are closely linked located on human chromosome 11. Therefore, this gene cluster may be related to AD.A total 147 AD patients 160 healthy controls were randomly recruited from June 2013 August 2014. levels measured using real-time quantitative reverse-transcriptase polymerase chain reaction enzyme-linked immunosorbent assay.APOA1, APOC3 significantly lower in than (P<0.01)....
A GO game can enhance mental health, but its effects on Alzheimer Disease (AD) remains unknown. To address the issue, 147 AD patients were randomly assigned into control (without GO-game intervention), Short-time GO-Game Intervention (SGGI, 1 h daily) and Long-time (LGGI, 2 groups. After 6-month follow-up, reduced mean score of Montgomery-Asberg Depression Rating Scales (MADRS) 4.72 (95% CI, 0.69 to 9.12) Hospital Anxiety Scale (HADS) 1.75 0.17-3.68), increased Global Assessment Functioning...
Brugada syndrome (BrS) is causing sudden cardiac death (SCD) mainly at young age. Studying the underlying mechanisms associated with BrS type I electrocardiogram (ECG) changes in presence of fever and roles autophagy for remains lacking.We sought to study pathogenic role an SCN5A gene variant fever-induced 1 ECG phenotype. In addition, we studied inflammation pathomechanism BrS.Human-induced pluripotent stem cell (hiPSC) lines from a patient harboring (c.3148G>A/p. Ala1050Thr) two healthy...
Calreticulin is down-regulated in the cortical neurons of patients with Alzheimer’s disease (AD) and may be a potential biomarker for diagnosis AD. A total 128 AD were randomly recruited from May 2012 to July 2013. The mRNA levels calreticulin measured serum tested subjects using real-time quantitative reverse transcriptase-PCR (real-time qRT-PCR). Serum determined by ELISA Western Blot. significantly lower than those healthy group (p < 0.01). baseline characters indicated that sample...
In this study, we investigated the mechanisms through which microRNAs (miRNAs or miRs) regulate lung development after birth, as well role of miRNAs in bronchopulmonary dysplasia (BPD). For purpose, a total 90 neonatal Wistar rats were randomly and equally assigned to either model group control group. On postnatal days 3, 7 14, tissues collected for histological analysis determine morphological changes. The expression levels proliferating cell nuclear antigen (PCNA) platelet endothelial...
// Linjie Zhao 1,2* , Chuan Yu Shengtao Zhou Wayne Bond Lau 3 Bonnie 4 Zhongyue Luo 5 Qiao Lin Huiliang Yang 6 Xuan 1,2 Tao Yi Xia and Yuquan Wei 1 Department of Gynecology Obstetrics, Key Laboratory Obstetrics & Gynecologic Pediatric Diseases Birth Defects Ministry Education, West China Second Hospital, Chengdu, 2 The State Biotherapy, Sichuan University, Emergency Medicine, Thomas Jefferson University Philadelphia, PA, USA Surgery, Kaiser Permanente Santa Clara Medical Center, Clara, CA,...
Previous studies have demonstrated that oxidative stress‑induced lung injury is involved in the occurrence and developmental process of bronchopulmonary dysplasia (BPD). The present study assessed whether DNA damage occurs early stages hyperoxia‑induced BPD neonatal rats evaluated expression localization repair gene, 8‑oxoguanine glycosylase 1 (OGG1), upon exposure to hyperoxia. Neonatal primary cultured rat alveolar epithelial type II (AECII) cells were exposed hyperoxia (90% O2) or...