A5033666014- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Infective Endocarditis Diagnosis and Management
- Cardiac Valve Diseases and Treatments
- Takotsubo Cardiomyopathy and Associated Phenomena
- Ion channel regulation and function
- Cardiac Structural Anomalies and Repair
- Heart Failure Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Aortic Disease and Treatment Approaches
- Acute Myocardial Infarction Research
- Cardiac Health and Mental Health
- Viral Infections and Immunology Research
- Long-Term Effects of COVID-19
- Infectious Diseases and Tuberculosis
- Neuroscience and Neural Engineering
- COVID-19 Clinical Research Studies
- Receptor Mechanisms and Signaling
- Cardiomyopathy and Myosin Studies
- Mechanical Circulatory Support Devices
- Thyroid Disorders and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
Ruhr University Bochum
2011-2025
BG University Hospital Bergmannsheil Bochum
2009-2024
LWL-Universitätsklinikum Bochum
2022
St. Josef-Hospital
2022
Abstract Background Several reports have described Takotsubo syndrome (TTS) secondary to thyrotoxicosis. A complex interaction of central and peripheral catecholamines with thyroid homeostasis has been suggested. In this study, we analysed sequential hormone profiles during the acute phase TTS. Methods Thyrotropin (TSH), free T4 (FT4) T3 (FT3) concentrations were at predefined time points in 32 patients presenting TTS or coronary (ACS, n = 16 each group) a 2‐year period two German university...
Recently, abnormal thyroid function was shown to be common in patients with Takotsubo syndrome (TTS), being classified into "endocrine-type" and "stress-type" responses. The aim of this study investigate the association between homeostasis TTS a larger international registry.
Abstract Data on the use of wearable cardioverter defibrillator (WCD) among patients after cardiac implantable electronic device explantation 1- to 3-chamber systems (ICD) are sparse. Accordingly, several guidelines give a different recommendation regarding WCD indication in this cohort. We aimed study baseline characteristics and outcome treated with ICD explantation. The primary is appropriate shock. Within multicenter registry 109 received bridge time ICD-system until reimplantation due...
Several P-wave indices are associated with the development of atrial fibrillation (AF). However, previous studies have been limited in their ability to reliably diagnose episodes AF. Implantable loop recorders allow long-term, continuous, and therefore more reliable detection AF.The aim this study is identify evaluate ECG parameters for predicting AF by analyzing patients recorders.This included 366 (mean age 62 ± 16 years, mean LVEF 61 6%, 175 women) without who underwent recorder...
Brugada syndrome (BrS) is causing sudden cardiac death (SCD) mainly at young age. Studying the underlying mechanisms associated with BrS type I electrocardiogram (ECG) changes in presence of fever and roles autophagy for remains lacking.We sought to study pathogenic role an SCN5A gene variant fever-induced 1 ECG phenotype. In addition, we studied inflammation pathomechanism BrS.Human-induced pluripotent stem cell (hiPSC) lines from a patient harboring (c.3148G>A/p. Ala1050Thr) two healthy...
Patients with progressive chronic kidney disease (CKD) are at higher risk of infections and complications from cardiac implantable electronic devices (CIED). In patients a primary or secondary prophylactic indication, defibrillators (ICD) can prevent sudden deaths (SCD). We retrospectively compared transvenous-ICD (TV-ICD) intermuscularly implanted subcutaneous-ICD (S-ICD) associated complication rates together hospitalizations in recipients stage 4 disease.
The effects of sacubitril/valsartan in patients with chronic heart failure reduced ejection fraction (HFrEF) were recently reported. However, the hemodynamic impact this well-established treatment HFrEF has been poorly systematically researched.We aimed to investigate among HFrEF.Between 2016 and 2020, we retrospectively collected data for treated at University Medical Center Mannheim, Germany. Data 240 available. We analyzed echocardiographic parameters, all-cause hospitalization,...
To compare clinical outcomes among patients with heart failure and reduced ejection fraction (HFrEF) according to body mass index (BMI) after initiating treatment an angiotensin-receptor neprilysin inhibitor (ARNI).We gathered data from 2016 2020 at the University Medical Center Mannheim; 208 consecutive were divided into two groups BMI (< 30 kg/m2 ; n = 116, ≥ 92). Clinical outcomes, including mortality rate, all-cause hospitalizations congestion, systematically analysed.At 12-month...
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is associated with arrhythmic events which may lead to sudden cardiac death (SCD). A leading therapy for CPVT besides medical treatment beta-blockers the use of an implantable cardioverter-defibrillator (ICD). For this paper we compared data from a pooled analysis get further evidence about complications transvenous and subcutaneous ICDs. We gathered search PubMed, Web Science, Cochrane Library Cinahl. our analysis, chose 30...
Background: Cephalic vein cutdown (CVC) and subclavian puncture (SVP) are the most commonly used access sites for transvenous lead placement of cardiac implantable electronic devices (CIEDs). Limited knowledge exists about long-term patency vascular lumen housing leads. Methods: Among 2703 patients who underwent CIED procedures between 2005 2013, we evaluated phlebographies 162 scheduled an elective replacement (median 6.4 years after first operation). The were divided into four stenosis...
Fever is a potential side effect of the Covid-19 vaccination. Patients with Brugada syndrome (BrS) have an increased risk life-threatening arrhythmias when experiencing fever. Prompt treatment antipyretic drugs suggested in these patients.To evaluate incidence and management fever within 48 h from vaccination among BrS patients.One hundred sixty-three consecutive patients were enrolled prospective registry involving five European hospitals dedicated inherited disease ambulatory.The mean age...
Abstract Background Guidelines classify sacubitril/valsartan as a significant part of medical treatment heart failure with reduced ejection fraction (HFrEF). Data have shown that the HbA1c levels in patients diabetes mellitus could be impacted by sacubitril/valsartan. A possible positive effect treated on outcome and echocardiography parameters is not well studied yet. Aims The aim present study was to compare impact life‐threatening arrhythmias, atrial fibrillation, different congestion...
Background Data on the use of wearable cardioverter-defibrillator (WCD) among patients with myocarditis remain sparse. Consequently, evidence for guideline recommendations in this patient population is lacking. Methods and Results In total, 1596 consecutive were included a multicenter registry from 8 European centers, 124 (8%) having received WCD due to reduced left ventricular ejection fraction or prior tachyarrhythmia. The mean age was 51.6±16.3 years, 74% being male. Patients discharged...
The benefit of implantable cardioverter-defibrillator (ICD) in elderly patients has been questioned. In the present study, we aimed to analyse outcome different age groups with ICD implantation.
The treatment with sacubitril/valsartan in patients suffering from chronic heart failure reduced ejection fraction increases left ventricular and decreases the risk of sudden cardiac death. We conducted a retrospective analysis regarding impact age differences on outcome fraction. Patients were defined as adults if ≤65 years (n = 51) older >65 76). incidence arrhythmias at 1-year follow-up was comparable both groups (30.8 vs 26.5%; p 0.71). mortality rate adult is significantly lower...
The angiotensin receptor-neprilysin inhibitor (ARNI) decreases cardiovascular mortality in patients with chronic heart failure a reduced ejection fraction (HFrEF). Data regarding the impact of ARNI on outcome HFrEF according to etiology are limited.One hundred twenty-one consecutive from years 2016 2017 were included at Medical Centre Mannheim Heidelberg University and treated current guidelines. Left ventricular (LVEF) was numerically improved during treatment both patient groups, that...
Background: Psychosocial stress has been associated with the development and progression of atherosclerotic cardiovascular disease (CVD). Previously, we reported subtle differences in global longitudinal strain somatically healthy women a psychiatric diagnosis borderline personality disorder (BPD). This study aimed to investigate impact BPD on segmental myocardial wall motion using speckle tracking echocardiography (STE) analysis. Methods: A total 100 aged between 18 38 years were included...
Diabetes mellitus is a major cardiovascular risk factor for the development of coronary artery disease, but knowledge about impact diabetes on outcome patients with myocardial infarction non-obstructive arteries limited. The aim this study was to investigate prognostic in- and out-of-hospital adverse events in troponin-positive arteries. A total 373 between 2010 2021 at Bergmannsheil University Hospital Bochum were enrolled, including 65 diabetics 307 nondiabetics. median follow-up 6.2...
The clinical significance of optimal pharmacotherapy for inherited arrhythmias such as short QT syndrome (SQTS) and long (LQTS) has been increasingly recognised. advancement gene technology opened up new possibilities identifying genetic variations investigating the pathophysiological roles mechanisms arrhythmias. Numerous variants in various genes have proven to be causative Studies demonstrated that effectiveness certain drugs is specific patient or genotype, indicating important role...
Wearable cardioverter defibrillator (WCD) can protect patients from sudden cardiac death due to ventricular tachyarrhythmias and serve as a bridge decision of definite implantation. The aim this analysis an international, multicenter WCD registry was identify predictors sustained tachycardia (VT) and/or fibrillation (VF) in population.
Implantable cardioverter defibrillators (ICD) prevent sudden cardiac death (SCD). Patients with end-stage renal disease (ESRD) requiring dialysis are at a very high risk of infection from implantable electronic device (CIED) implantation as well mortality. In the present study, we compared long-term complications and outcomes between subcutaneous ICD (S-ICD) transvenous (TV-ICD) recipients.