A5101938665- Ocular Infections and Treatments
- Cancer Genomics and Diagnostics
- Liver Disease Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Hepatitis C virus research
- Cardiac electrophysiology and arrhythmias
- Lung Cancer Treatments and Mutations
- Hepatitis B Virus Studies
- Cancer Immunotherapy and Biomarkers
- Ocular Surface and Contact Lens
- Genetic factors in colorectal cancer
- Neuroscience and Neural Engineering
- Glaucoma and retinal disorders
- Ion channel regulation and function
- Colorectal Cancer Treatments and Studies
- Autophagy in Disease and Therapy
- COVID-19 Clinical Research Studies
- Immune Response and Inflammation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ocular Oncology and Treatments
- Immunotherapy and Immune Responses
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Corneal surgery and disorders
- Immune Cell Function and Interaction
Xiamen University
2025
Qingdao University
2015-2024
Affiliated Hospital of Qingdao University
2015-2024
Chengdu University of Technology
2020-2024
Zero to Three
2023-2024
Xinjiang Medical University
2020-2024
Shanghai Ninth People's Hospital
2023-2024
Sichuan University of Science and Engineering
2024
Peking University
2009-2023
University Medical Centre Mannheim
2018-2023
On February 22, 2013, the FDA licensed ado-trastuzumab emtansine (Kadcyla; Genentech, Inc.) for use as a single agent treatment of patients with human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer (MBC) who previously received trastuzumab and taxane, separately or in combination. The clinical basis licensure was phase III trial 991 HER2-positive MBC that randomly allocated to receive (n=495) lapatinib combination capecitabine (n=496). coprimary endpoints were...
Older adults with acute myeloid leukemia (AML) who are not fit for standard chemotherapy historically have poor outcomes. Approximately 12-15% of older patients AML harbor isocitrate dehydrogenase 2 (IDH2) gene mutations. Enasidenib is an oral inhibitor mutant IDH2 proteins. Among 39 newly diagnosed mutant-IDH2 received enasidenib monotherapy in this phase I/II trial, median age was 77 years (range 58-87) and 23 (59%) had antecedent hematologic disorder. The number treatment cycles 6.0...
<h3>Background</h3> Whether insulin resistance predicts ischemic stroke (IS) is still a matter of debate. <h3>Objective</h3> To determine the association between (IR) and risk first in large, multiethnic, stroke-free cohort without diabetes. <h3>Design</h3> Prospective, population-based study. <h3>Setting</h3> Longitudinal epidemiologic <h3>Participants</h3> A 1509 nondiabetic participants from Northern Manhattan Study (mean [SD] age, 11 [10] years; 64.2% women; 58.9% Hispanics). <h3>Main...
Rhino-orbito-cerebral mucormycosis(ROCM) is an invasive fungal infection that usually occurs in immunocompromised patients and sometimes presents as orbital apex syndrome(OAS) initially. It rapidly fatal without early diagnosis treatment. We report the cases of ROCM presenting with OAS initially order to raise attention clinicians. retrospectively investigated eleven admitted between January 2006 December 2013. analyzed clinical features, results laboratory radiological examinations, nasal...
Abstract Excessive activation of hepatic stellate cells (HSCs) is a key step in liver fibrogenesis. Here we report that CUG-binding protein 1 (CUGBP1) expression elevated HSCs and positively correlates with fibrosis severity human biopsies. Transforming growth factor-beta (TGF-β) selectively increases CUGBP1 cultured p38 mitogen-activated kinase (MAPK)-dependent manner. Knockdown inhibits alpha smooth muscle actin (α-SMA) promotes interferon gamma (IFN-γ) production vitro . We further show...
// Qingyang Gu 1, * , Bin Zhang Hongye Sun 2 Qiang Xu Yexiong Tan 3 Guan Wang Qin Luo Weiguo 1 Shuqun Yang Jian Li Jing Fu Lei Chen Shengxian Yuan Guibai Liang Qunsheng Ji Shu-Hui Chi-Chung Chan Weiping Zhou Xiaowei 4 Hongyang Douglas D. Fang 5 Discovery Services, WuXi AppTec Co., Ltd., Waigaoqiao Free Trade Zone, Shanghai, 200131 China Genome Center, Eastern Hepatobiliary Surgery Hospital/Institute of Pathology and Laboratory Medicine, Hospital the University Pennsylvania, Philadelphia, PA...
Abstract Body weight is a component of the mechanical theory OA (osteoarthritis) pathogenesis. Obesity was also found to be risk factor for digital involving non-weight-bearing joints, which suggested that metabolism influences occurrence and progression OA. The metabolic origin has been partially attributed involvement adipokines, such as leptin, levels are significantly positively correlated with cartilage degeneration in patients. However, mechanisms by leptin-induced occurs poorly...
Abstract Background Tumor mutation burden (TMB), DNA mismatch repair deficiency (dMMR), microsatellite instability (MSI), and PD‐L1 amplification (PD‐L1 AMP) may predict the efficacy of PD‐1/PD‐L1 blockade. With broadening landscape immunotherapy use, it is important to identify patients who are likely benefit from therapy. This study aimed characterize distributions these biomarkers explore relationships among for Chinese with cancer. Methods In this study, we examined aforementioned in...
Hinokitiol (β-thujaplicin) is an important component of the essential oil extracted from Chamaecyparis obtuse , which prevents decay and decomposition temple shrine buildings in Japan. Hinokiol has been shown to have a detrimental effect on various fungi such as Candida albicans saprophytic fungi. However how hinokitiol works against Aspergillus fumigatus ( A. ) not claimed. This study aims investigate adverse effects disruption cell wall membrane explore possible potential mechanisms or...
To explore the relationship between lipid profile components and incident ischemic stroke in a stroke-free prospective cohort.Population-based cohort study.Northern Manhattan, New York.Stroke-free community residents. Intervention As part of Northern Manhattan Study, baseline fasting blood samples were collected on residents followed up for mean 7.5 years.Cox proportional hazard models used to calculate ratios 95% confidence intervals after adjusting demographic risk factors. In secondary...
Exposure-response (E-R) analyses for ado-trastuzumab emtansine (T-DM1, Kadcyla) were performed using data from a randomized, active control (lapatinib plus capecitabine) trial in patients with human epidermal growth factor 2-positive metastatic breast cancer. Kaplan-Meier survival stratified by T-DM1 trough concentration on day 21 of cycle 1 (Cmin,C1D21) overall (OS) and progression-free (PFS). E-R indicated that after adjusting baseline risk factors, higher exposure is associated improved...
Summary Background Racial and ethnic disparities exist for hepatitis C virus (HCV) treatment hepatocellular carcinoma (HCC) survival. Aim To evaluate the impact of HCV on such disparities. Methods In a retrospective cohort study, we analysed 6069 patients with HCV‐related HCC (54.2% Asian, 30.1% White, 8.5% Black, 7.3% Hispanic) from centres in United States Asia. Results The mean age was 61, 60, 59 68, respectively, Hispanic Asian patients. Black were most likely to have Barcelona Clinic...
The co-circulation of respiratory viruses, including SARS-CoV-2, Influenza A (Flu A), B B), and syncytial virus (RSV), poses a significant public health threat. Timely recognition these viruses allows healthcare professionals to implement effective infection control measures, allocate medical resources properly, prevent complications from incorrect treatments. Multiplex nucleic acid testing Point-of-care test (mNAT-POCT) circumvents issues traditional tests, such as high demands on...