A5033303221- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Ion channel regulation and function
- Cardiac Valve Diseases and Treatments
- Cardiomyopathy and Myosin Studies
- Receptor Mechanisms and Signaling
- Venous Thromboembolism Diagnosis and Management
- Ginkgo biloba and Cashew Applications
- Advanced Glycation End Products research
- Nutrition, Genetics, and Disease
- Ubiquitin and proteasome pathways
- ECG Monitoring and Analysis
- Heart Rate Variability and Autonomic Control
- Cardiac Fibrosis and Remodeling
- Histone Deacetylase Inhibitors Research
- Advanced MRI Techniques and Applications
- Chemokine receptors and signaling
- Cardiac Structural Anomalies and Repair
- EEG and Brain-Computer Interfaces
- interferon and immune responses
- Neurological Disease Mechanisms and Treatments
- Cardiovascular Function and Risk Factors
- Protein Degradation and Inhibitors
Henan Provincial People's Hospital
2013-2025
Zhengzhou Central Hospital
2019-2025
Zhengzhou University
2022-2023
Fu Wai Hospital
2023
Affiliated Zhongshan Hospital of Dalian University
2020
Dalian Medical University
2012-2013
First Affiliated Hospital of Dalian Medical University
2012-2013
Abstract Atherosclerosis (AS), with associated risk of stroke or cerebrovascular disease, is one the most common causes death globally. It has been well established that tripartite motif‐containing protein 7 Tripartite Motif‐containing ( Trim7 ), as an E3 ubiquitin ligase, involved in ubiquitination and thus regulating cellular proliferation. Moreover, TRIM7 upregulated advanced carotid AS. However, detailed mechanism on regulation AS remains unclear. In present study, we firstly discovered...
Background A prolonged PR interval is a sign of increased risk cardiac arrhythmia. Recent genome-wide association studies found that the single-nucleotide polymorphism (SNP) rs3825214 in T-box 5 (TBX5) was positively associated with interval, QRS duration, QT and common arrhythmia disorders such as atrial fibrillation (AF) advanced atrioventricular block. However, other independent replication are required to validate result. This study assessed associations between ECG parameters, AF,...
The clinical significance of optimal pharmacotherapy for inherited arrhythmias such as short QT syndrome (SQTS) and long (LQTS) has been increasingly recognised. advancement gene technology opened up new possibilities identifying genetic variations investigating the pathophysiological roles mechanisms arrhythmias. Numerous variants in various genes have proven to be causative Studies demonstrated that effectiveness certain drugs is specific patient or genotype, indicating important role...
Nuclear receptor-binding SET domain 3 (NSD3) is a lysine methyltransferase that plays important roles in multiple biological activities; however; its potential the cardiovascular system remain unknown. In this study, we found NSD3 expression reduced by isoproterenol (ISO) stimuli both vitro and vivo. Overexpression of attenuates ISO-induced cardiomyocyte hypertrophy. Mechanistically, ISO treatment decreases H3K27me2/3 modifications on atrial natriuretic factor (ANF) promoter suppressing...
<h3>Background</h3> Atrial fibrillation (AF) is the most common supraventricular tachycardia encountered in clinical practise associated with pronounced morbidity, mortality, and socio-economic burden. To date, mechanism of AF still not fully understood but believed to be multifactorial including genetic predisposition. A number loci genes related disorder have been reported. Recently, several genome-wide association studies (GWAS) yielded associations between sequence variants ECG variables....
Abstract Objective： To evaluate whether the effect of radiofrequency ablation can be improved by using Sacubitril/Valsartan (S/V) to control blood pressure in hypertensive patients with persistent atrial fibrillation. Methods: A total 63 and 67 hypertension fibrillation were enrolled an S/V group ACEI/ARB group, respectively. All underwent (RFCA). The two groups was controlled within range 100–140 mmHg (high pressure) 60–90 (low pressure). clinical indexes observed after 12 months follow-up....
<title>Abstract</title> Background Permanent left bundle branch area pacing (LBBAP) can correct block. However, the correction of LBBAP in right block (RBBB) is undefined. Objective To investigate effect and safety permanent patients with RBBB. Methods Ninety-two consecutive who successfully experienced were recruited from May. 2019 to Dec. 2022 our single center. Twenty RBBB analyzed study. They followed up at 1, 3, 6 12 months after procedure. The QRS duration (QRSd) on V1 lead 12-lead...
<h3>Objectives</h3> The prolongation of the PR interval has been considered as an increased risk atrial fibrillation (AF), pacemaker implantation and mortality. Several recent genome-wide association studies (GWAS) have yielded associations between common variants echocardiogram (ECG) parametres. SNP rs3825214 in TBX5 gene was shown correlating with interval, QRS duration, QT verified significant diseases such fibrillation, advanced AV block. aim this study is to further assess ECG...
<h3>Objectives</h3> Ventricular tachycardia is a kind of serious arrhythmia. Some recent Genome-wide association studies identified susceptibility locus, among which SNP rs11970286 has documented role in the regulation QT interval. However, few researchs foucs on relevance common variants and ventricular tachycardia. We hypothesised that this act <h3>Methods</h3> 220 patients diagnosed as 1000 healthy subjects were included present study. All genotyped for SNPs using Rotor-Gene TM 6000 High...
Objective To investigate the correlation between parameters of heart rate variability (HRV) and times early events treatments in patients underwent first implantation implantable cardioverter-defibrillator (ICD) , to evaluate its predictive value. Methods A total 56 patients, who ICD our hospital January 2012 October 2015, were retrospectively analyzed, including 31 males 25 females. All dynamic electrocardiography (ECG) examination before implantation, HRV was assessed both time...
Objective To investigate the feasibility and effect of His bundle pacing (HBP) guided by three-dimension mapping system. Method Thirty patients underwent permanent through system were enrolled in this study. The average age study group was 59.2 years, with 17 male patients. Factors including whole procedure time, X-ray exposure lead parameters, QRS duration before after operation analyzed SPSS. Results The divided into selective HBP (only capture bundle) non-selective (capture...
Abstract Background Contemporary researchers found single nucleotide polymorphisms (SNPs) in nitric oxide synthase 1 adaptor protein (NOS1AP) gene are associated with altered QT intervals and SCD. However, the clinical utility implications of these SNP have not been described. This study aims to explore SNPs patients implantable cardioverter defibrillator (ICD) for secondary prevention. Methods We firstly conducted a case-control evaluate associations between hot-spot NOS1AP (rs12143842,...