A5103018743- Laser Applications in Dentistry and Medicine
- Spinal Cord Injury Research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Medical and Biological Ozone Research
- Hydrogen's biological and therapeutic effects
- Spine and Intervertebral Disc Pathology
- Bee Products Chemical Analysis
- Pain Mechanisms and Treatments
- Cancer-related molecular mechanisms research
- Optical Imaging and Spectroscopy Techniques
- Spinal Fractures and Fixation Techniques
- Diabetic Foot Ulcer Assessment and Management
- Spectroscopy and Chemometric Analyses
- Neuropeptides and Animal Physiology
- Bone Metabolism and Diseases
- Bone health and osteoporosis research
- Nerve injury and regeneration
- Pelvic and Acetabular Injuries
- Spaceflight effects on biology
- Leptospirosis research and findings
- Antimicrobial Peptides and Activities
- Signaling Pathways in Disease
- Cardiac Valve Diseases and Treatments
- S100 Proteins and Annexins
- Neuroinflammation and Neurodegeneration Mechanisms
Xijing Hospital
2016-2025
Air Force Medical University
2016-2025
Southern Medical University
2022
Nanfang Hospital
2022
Sun Yat-sen University
1996
Sun Yat-sen Memorial Hospital
1996
Although microplastics have been detected in human blood, placenta and other tissues. In this study, for the first time, we characterized presence variation of microplastic deposition patterns three skeletal tissues, namely bone, cartilage, intervertebral discs. Forty fragments were observed 24 samples from disc, ranging 25.44 to 407.39 μm diameter. The abundance disc (61.1 ± 44.2 particles/g) was higher than those bone (22.9 15.7 cartilage tissue (26.4 17.6 particles/g). average sizes discs...
Neurotoxic microglia and astrocytes begin to activate participate in pathological processes after spinal cord injury (SCI), subsequently causing severe secondary damage affecting tissue repair. We have previously reported that photobiomodulation (PBM) can promote functional recovery by reducing neuroinflammation SCI, but little is known about the underlying mechanism. Therefore, we aimed investigate whether PBM ameliorates modulating activation of SCI.Male Sprague-Dawley rats were randomly...
Secondary spinal cord injury (SCI) often causes the aggravation of inflammatory reaction and nerve injury, which affects recovery motor function. Bone-marrow-derived macrophages (BMDMs) were recruited to injured area after SCI, M1 polarization is key process for inducing response neuronal apoptosis. We previously showed that photobiomodulation (PBM) can inhibit phenotype BMDMs reduce inflammation, but underlying mechanisms are unclear. The purpose this study explore potential target...
After spinal cord injury (SCI), reactive astrocytes can be classified into two distinctive phenotypes according to their different functions: neurotoxic (A1) and neuroprotective (A2) astrocytes. Our previous studies proved that photobiomodulation (PBM) promote motor function recovery improve tissue repair after SCI, but little is known about the underlying mechanism. Therefore, we aimed investigate whether PBM contributes SCI by regulating activation of Male rats subjected clip-compression...
Abstract Macrophages play key roles in the secondary injury stage of spinal cord (SCI). M1 macrophages occupy lesion area and secrete high levels inflammatory factors that hinder repair, M2 can neurotrophic promote axonal regeneration. The regulation macrophage secretion after SCI is critical for repair. Low‐level laser therapy (810‐nm) (LLLT) boost functional rehabilitation rats SCI; however, mechanisms remain unclear. To explore this issue, we established an vitro model low‐level...
Spinal cord injury (SCI) is a catastrophic disease with complex pathogenesis that includes inflammation, oxidative stress, and glial scar formation. Macrophages are the main mediators of inflammatory response distributed in epicentre SCI. have neurotoxic neuroprotective phenotypes (also known as classically alternatively activated macrophages or M1 M2 macrophages) associated pro- anti- gene expression. Our previous study demonstrated photobiomodulation (PBM) alters polarization state SCI...
Abstract Background Many studies have recently highlighted the role of photobiomodulation (PBM) in neuropathic pain (NP) relief after spinal cord injury (SCI), suggesting that it may be an effective way to relieve NP SCI. However, underlying mechanisms remain unclear. This study aimed determine potential PBM Methods We performed systematic observations and investigated mechanism intervention rats Using transcriptome sequencing, we screened CXCL10 as a possible target molecule for validated...
Increasing evidence indicates that mitochondrial fission imbalance plays an important role in delayed neuronal cell death. Our previous study found photobiomodulation improved the motor function of rats with spinal cord injury. However, precise mechanism remains unclear. To investigate effect on after injury, this study, we treated rat models injury 60-minute (810 nm, 150 mW) every day for 14 consecutive days. Transmission electron microscopy results confirmed swollen and fragmented...
Abstract Given afferent functions, sensory nerves have recently been found to exert efferent effects and directly alter organ physiology. Additionally, several studies highlighted the indirect but crucial role of in regulation physiological function osteoclasts. Nonetheless, evidence regarding direct nerve influence on osteoclasts is lacking. In current study, we that high levels signals were transported from into Furthermore, hypersensitivity significantly increased osteoclastic bone...
Abstract Previous studies on spinal cord injury (SCI) have confirmed that percutaneous photobiomodulation (PBM) therapy can ameliorate immunoinflammatory responses at sites of injury, accelerate nerve regeneration, suppress glial scar formation and promote the subsequent recovery locomotor function. The current study was performed to evaluate a large‐animal model employing implanted optical fibers accurately irradiate targeted segments. method's feasibility irradiation parameters do not...
Mitochondrial transplantation is a promising treatment for spinal cord injury (SCI), but it has the disadvantage of low efficiency mitochondrial transfer to targeted cells. Here, we demonstrated that Photobiomodulation (PBM) could promote process, thus augmenting therapeutic effect transplantation. In vivo experiments, motor function recovery, tissue repair, and neuronal apoptosis were evaluated in different groups. Under premise transplantation, expression Connex36 (Cx36), trend...
ABSTRACT Natural genetic transformation of Streptococcus pneumoniae , an important human pathogen, mediates horizontal gene transfer for the development drug resistance, modulation carriage and virulence traits, evasion host immunity. Transformation frequency differs greatly among pneumococcal clinical isolates, but molecular basis biological importance this interstrain variability remain unclear. In study, we characterized other associated phenotypes 208 S. isolates representing at least 30...
Electromagnetic fields (EMF) was considered as a non-invasive modality for treatment of osteoporosis while the effects were diverse with EMF parameters in time domain. In present study, we extended analysis characteristics from domain to frequency domain, aiming investigate four kinds (LP (1-100 Hz), BP (100-3,000 HP (3,000-50,000 Hz) and AP (1-50,000 Hz)) on ovariectomized (OVX) (OP) mice. Forty-eight 3-month-old female BALB/c mice equally assigned Sham, OVX, OVX + LP, BP, groups (n = 8)....
Background: Insufficient neuronal mitochondrial bioenergetics supply occurs after spinal cord injury (SCI), leading to apoptosis and impaired motor function. Previous reports have shown that photobiomodulation (PBM) could reduce promote functional recovery, but the underlying mechanism remains unclear. Therefore, we aimed investigate whether PBM improved prognosis by promoting SCI. Methods: Sprague Dawley rats were randomly divided into four groups: a Sham group, an SCI + group Compound C...