A5035843312- Cancer therapeutics and mechanisms
- Drug Transport and Resistance Mechanisms
- Synthesis and biological activity
- Diabetes Treatment and Management
- Chemical Synthesis and Analysis
- Pancreatic function and diabetes
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Biological Evaluation
- Receptor Mechanisms and Signaling
- HIV/AIDS drug development and treatment
- Click Chemistry and Applications
- Synthesis of β-Lactam Compounds
- Antimicrobial Peptides and Activities
- Andrographolide Research and Applications
- Neuropeptides and Animal Physiology
- RNA Interference and Gene Delivery
- Metabolism, Diabetes, and Cancer
- Neonatal Respiratory Health Research
- Synthesis and Biological Activity
- Peptidase Inhibition and Analysis
- Protein Degradation and Inhibitors
- Toxin Mechanisms and Immunotoxins
- Peroxisome Proliferator-Activated Receptors
- Carbohydrate Chemistry and Synthesis
- Nanoparticle-Based Drug Delivery
Foshan University
2009-2025
East China University of Science and Technology
2025
National Chung Cheng University
2022-2024
Chengdu University of Technology
2023-2024
State Key Laboratory of Oral Diseases
2024
Xinjiang University
2024
Sichuan University
2024
China Pharmaceutical University
2013-2022
Guangdong Medical College
2022
Southeast University
2010-2020
Objective: To compare the effects of single and repeated courses corticosteroids on brain growth in fetal sheep. Methods: Pregnant sheep were given intramuscular betamethasone (0.5 mg/kg) at 104 days' gestation followed 111, 118, 124 days by equivalent volumes sterile normal saline (n = 12) or 12). Controls received all four intervals Lambs delivered 125 (preterm) 145 (term) days. After perfusion, we measured weights (grams) for whole brain, cerebrum, cerebellum, stem, (milliliters) maximum...
Abstract Glucocorticoids regulate oligodendrocyte maturation and the myelin biosynthetic pathways. Synthetic glucocorticoids, corticosteroids have been successfully used in clinical practice as a single course to enhance lung reduce mortality morbidity preterm infants with no long‐term neurologic or cognitive side effects. However, trend has arisen use repeated courses despite an absence of safety data from trials. We examined effects clinically appropriate, maternally administrated, on...
Previous studies have shown that repeated doses of corticosteroids given to pregnant sheep improve postnatal lung function, but restrict fetal growth. Repeated administration directly the fetus also enhances function. The purpose present study was investigate and characterize relative effects on growth maternal treatments by body, organ, placental weights.Date-bred were intramuscular betamethasone or saline either mother three occasions at weekly intervals commencing 104 days gestation,...
Aflatoxin B1 (AFB1) is a secondary metabolite produced by Aspergillus flavus and parasitic aspergillus, mainly existing in cereals, peanuts, corn, other crops, which seriously endanger poultry, human health, environment. Morin, flavonoid compound extracted from moraceae plants, possess antioxidant, antibacterial, anti-inflammatory effects. However, whether morin has protective effect on AFB1-induced liver kidney damage chicks not been specifically reported. In this study, we confirmed the of...
Abstract The development of highly stable and ultra‐long organic room temperature phosphorescence (RTP) materials holds great promise for applications in anti‐counterfeiting information protection. To improve the encryption level, exploration with tunable afterglow features is urgent need. Hereby, a series long‐lived systems RTP developed by incorporating benzocarbazole derivatives into polyvinyl alcohol (PVA) matrix (BCz@PVA). Notably, BCz@PVA film exhibits outstanding behavior an ultralong...
We describe a peptide vaccine model based on the mimicry of surface coat protein pathogen. This used macromolecular assemblage approach to amplify antigens in liposomes or micelles. The key components consisted an oligomeric lysine scaffolding covalently 4-fold and lipophilic membrane-anchoring group further noncovalently many-fold liposomal micellar form. A antigen derived from third variable domain glycoprotein gp120 human immunodeficiency virus type 1 (HIV-1), consisting neutralizing,...
Twelve novel dicoumarol glucagon-like peptide 1 (GLP-1) conjugates were designed, synthesized, and tested for biological activity. All derivatives retained receptor activation efficacy, exhibited improved albumin affinity in vitro stability rat plasma. The vivo elimination half-lives of 13c 13l (22.07 18.78 h, respectively) much longer than those the GLP-1 agonists exendin-4 (2.82 h) liraglutide (12.53 h). prolonged antidiabetic effects on db/db mice confirmed by hypoglycemic efficacy test...
The aim of this research was to produce novel antitumor fluoroquinolones from antibacterial analogs by introduction a heterocyclic ring as bioisostere the C-3 carboxylic acid group. To end, two series eleven s-triazole derivatives bearing functionalized side chains Schiff bases and Schiff–Mannich were designed synthesized. Structures characterized elemental analysis spectral data after which in vitro activity against L1210, CHO HL60 cell lines evaluated MTT assay. Compounds possessing free...
Closed-loop glucose-responsive insulin delivery with excellent biocompatibility has the potential to improve health and quality of life diabetic patients. Herein, we developed an system using a pH-sensitive peptide hydrogel loaded glucose-specific enzyme. The designed can be used as carrier that is enzyme via self-assembly process under physiological conditions. When hyperglycemia encountered, enzymatic conversion glucose into gluconic acid leads decrease in local pH, disassembled because...
The increasing prevalence of multidrug-resistant bacteria is a significant global health threat. In contrast to conventional antibiotic treatments, photodynamic therapy (PDT) offers promising alternative by reducing the bacterial adaptability antibiotics and bactericides. However, traditional photosensitizers encounter poor antimicrobial efficacy due hydrophilicity photosensitizers, short lifespan, narrow diffusion radius reactive oxygen species (ROS), risk exacerbating inflammation. this...
Bovine neosporosis, a protozoal disease caused by Neospora caninum ( N. caninum), poses significant threat to the global cattle industry, resulting in substantial economic losses that are difficult quantify. The current lack of effective commercial vaccines and specific treatments highlights urgent need for development potent drugs against caninum. In this study, we investigate efficacy aurintricarboxylic acid (ATA), derivative polyaromatic carboxylic acid, both vitro vivo. Cell cytotoxicity...