A5101606228- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Neuropeptides and Animal Physiology
- Metabolism, Diabetes, and Cancer
- Receptor Mechanisms and Signaling
- Pharmacology and Obesity Treatment
- Acute Myeloid Leukemia Research
- Regulation of Appetite and Obesity
- Maternal Mental Health During Pregnancy and Postpartum
- vaccines and immunoinformatics approaches
- Plant-based Medicinal Research
- Pharmacological Effects and Toxicity Studies
- Viral gastroenteritis research and epidemiology
- Lymphoma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Organ Donation and Transplantation
- Ovarian function and disorders
- Peroxisome Proliferator-Activated Receptors
- Reproductive System and Pregnancy
- Chronic Myeloid Leukemia Treatments
- Protein Degradation and Inhibitors
- Reproductive Biology and Fertility
- Biochemical and Structural Characterization
- Oral health in cancer treatment
- Neurological Disease Mechanisms and Treatments
Jiaxing University
2017-2025
Zhejiang University
2024-2025
Dian Diagnostics (China)
2024
Children's Hospital of Zhejiang University
2023-2024
Shenyang Agricultural University
2023
Jiangsu Normal University
2022
China Pharmaceutical University
2011-2019
State Key Laboratory of Natural Medicine
2015-2016
Nanjing University of Chinese Medicine
2016
Jiangsu Provincial Academy of Traditional Chinese Medicine
2016
Abstract We aimed to assess the epidemiological characteristics of respiratory syncytial virus (RSV) infection in Chinese children at different phases coronavirus disease 2019 (COVID‐19) pandemic, that is, before, during pandemic and after easing restrictive measures. included 123 623 patients aged 0–18 years with symptoms who were suspected RSV from January 1, June 30, 2023 Hangzhou Children's Hospital. Clinical information test result extracted laboratory system. calculated positive rate...
Twelve novel dicoumarol glucagon-like peptide 1 (GLP-1) conjugates were designed, synthesized, and tested for biological activity. All derivatives retained receptor activation efficacy, exhibited improved albumin affinity in vitro stability rat plasma. The vivo elimination half-lives of 13c 13l (22.07 18.78 h, respectively) much longer than those the GLP-1 agonists exendin-4 (2.82 h) liraglutide (12.53 h). prolonged antidiabetic effects on db/db mice confirmed by hypoglycemic efficacy test...
Background and Purpose The short biological half‐life limits the therapeutic use of glucagon‐like peptide‐1 ( GLP ‐1) chemical modification to improve interaction peptides with serum albumin represents an effective strategy develop long‐acting peptide analogues. Coumarin, a natural product, is known bind tightly plasma proteins possesses many activities. Therefore, we designed synthesized series coumarin‐modified ‐1 derivatives, hypothesizing that conjugation coumarin would retain effects...
Glucagon-like peptide-1 (GLP-1) and glucagon (GCG) receptor dual agonist have promising therapeutic effects in the treatment of obesity diabetes. Moreover, GLP-1 cholecystokinin 2 (CCK2 ) agonists been shown to restore pancreas function improve glycaemic control preclinical studies. We describe, for first time, beneficial GLP-1/glucagon GLP-1/CCK2 agonists, which can be integrated into one peptide, resulting significant anti-diabetes anti-obesity effectiveness.The vitro potency this novel...
Abstract Antigen delivery based on non‐virus‐like particle self‐associating protein nanoscffolds, such as Aquifex aeolicus lumazine synthase (AaLS), is limited due to the immunotoxicity and/or premature clearance of antigen‐scaffold complex resulted from triggering unregulated innate immune responses. Here, using rational immunoinformatics prediction and computational modeling, we screen T epitope peptides thermophilic nanoproteins with same spatial structure hyperthermophilic icosahedral...
The combined use of gastrointestinal hormones for treating metabolic diseases is gaining increasing attention. potential developing novel dual agonists targeting both cholecystokinin 1 (CCK-1) receptor and glucagon-like peptide (GLP-1) to improve the treatment type 2 diabetes obesity have not been fully explored. In this investigation, we reported a series GLP-1/CCK-1 co-agonists constructed by linking C-terminus GLP-1 agonist (bullfrog GLP-1) N-terminus CCK-1 selective NN9056. comprehensive...
GLP-1 receptor (GLP-1R) and neuropeptide Y2 (Y2R) dual agonists have shown great potential to treat obesity type 2 diabetes (T2DM). We developed a multitarget strategy design monomeric based on Xenopus (xGLP-1) PYY3–36 analogues with activation activities GLP-1R Y2R. A novel peptide, 6q, was obtained via stepwise structure optimization in vitro screens. In db/db diet-induced (DIO) mice, 6q produced greater effects long-term glycemic control body weight reduction than Y2R monoagonist...
We aimed to assess the associated factors for adolescent depression, problem behavior and cognitive level in China.A total of 2,584 adolescents aged from 10 15 years old 2018 were included analyses. Information on a comprehensive set potential determinants was collected by questionnaire, including demographic, health-, school- family-related factors. Differences average scores behavior, across subgroups assessed two independent sample t-tests one-way analysis variance (ANOVA). The clinical...
We proposed that a pentapeptide, LVKGR amide, GLP-1 (32-36) derived from the gluco-incretin hormone, glucagon-like peptide-1 (GLP-1), might possess favorable actions against diabetes. Therefore, amide was synthesized and effects of it were examined in INS-1 cell streptozotocin-induced diabetic mice model. To determine protective on viability apoptosis, cells exposed to 1 μm streptozotocin (STZ) for 24 h. Results showed treatment decreased apoptosis rate significantly retained compared with...
GLP-1 analogs suffer from the main disadvantage of a short in vivo half-life. Lithocholic acid (LCA), one four bile acids human body, possesses high albumin binding rate. We therefore envisioned that LCA-based peptide delivery system could extend half-life by facilitating noncovalent peptides to serum albumin. On basis our previously identified Xenopus (1–3), series LCA-modified conjugates were designed (4a–4r), and bioactivity studies these performed identify compounds with balanced vitro...
A novel means for half-life extension of peptide drugs.<bold>3d</bold>has potential to be developed as a therapeutic agent T2DM.
Introduction Williams syndrome (WS) is a rare genetic disorder that impacts multiple systems and may cause developmental delays. These medical issues impose heavy burden on affected children their families. However, there was no study children’s health-related quality of life (HRQoL) with WS only two studies about family globally. Therefore, the primary purpose this to assess HRQoL caregivers in China, secondary identify potential determinants caregivers’ HRQoL. Methods In total, 101 were...