A5100786363- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Cardiovascular Function and Risk Factors
- Cardiac electrophysiology and arrhythmias
- Thyroid Cancer Diagnosis and Treatment
- Ion channel regulation and function
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Neonatal and fetal brain pathology
- Fetal and Pediatric Neurological Disorders
- Thyroid and Parathyroid Surgery
- Heart Failure Treatment and Management
- Nicotinic Acetylcholine Receptors Study
- Parkinson's Disease Mechanisms and Treatments
- Diabetes Treatment and Management
- Cardiac Health and Mental Health
- Heart Rate Variability and Autonomic Control
- RNA regulation and disease
- Functional Brain Connectivity Studies
- Cardiomyopathy and Myosin Studies
- Pharmacological Effects of Natural Compounds
- Medical Imaging Techniques and Applications
- Liver Disease Diagnosis and Treatment
- Synthesis of Organic Compounds
Wenzhou Medical University
2024-2025
Jilin University
2025
Guang’anmen Hospital
2017-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2024
Zhejiang Chinese Medical University
2024
First Affiliated Hospital of Zhengzhou University
2004-2024
Tianjin Medical University Cancer Institute and Hospital
2017-2024
Jiangsu Food and Pharmaceutical Science College
2023-2024
Huazhong University of Science and Technology
2015-2023
Hangzhou First People's Hospital
2018-2023
Atherosclerosis (AS) is widespread and develops into circulatory system problems. T cells play an essential regulatory role in AS occurrence development. So far, there no bibliometric research on AS. To learn more about cell development, 4,381 records were retrieved from Web of Science™ Core Collection. Then, these scientometrically analyzed using CiteSpace VOSviewer terms spatiotemporal distribution, author subject categories, topic references, keywords. Our analysis provides basic...
Abstract Interleukin 35 (IL-35) is a novel member of the IL-12 family, consisting an EBV-induced gene 3 (EBI3) subunit and P35 subunit. IL-35 immune-suppressive cytokine mainly produced by regulatory T cells. However, role in cancer metastasis progression not well understood. Here we demonstrate that overexpressed human pancreatic ductal adenocarcinoma (PDAC) tissues, overexpression associated with poor prognosis PDAC patients. has critical roles cell extravasation facilitating adhesion to...
// Rifeng Jiang 1, * , Jingjing Lingyun Zhao 1 Jiaxuan Zhang Shun Yihao Yao Shiqi Yang Shi Nanxi Shen Changliang Su Ju Wenzhen Zhu Department of Radiology, Tongji Hospital, Medical College, Huazhong University Science and Technology, Wuhan, China These authors have contributed equally to this work Correspondence to: Zhu, e-mail: zhuwenzhen@hotmail.com Keywords: diffusion kurtosis imaging, glioma, grading, cellular proliferation, Ki-67 Received: April 29, 2015 ...
Abstract Background and aims Heart failure (HF) presents a significant global health challenge due to its rising prevalence impact on disability. This study comprehensively analyse the burden of HF underlying causes. Methods results Using data from Global Burden Disease Study 2021, we analysed years lived with disability (YLD) HF, examining implications across diverse demographics geographic regions. In approximately 55.5 million [95% uncertainty interval (UI) 49.0–63.8] people worldwide...
This study aimed to conduct a bibliometric analysis of published studies on the association between coronary heart disease (CHD) and depression or anxiety. The also identify leading authors, institutions, countries determine research hotspots obtain some hints from speculated future frontiers. Publications about CHD anxiety 2004 2020 were collected Web Science Core Collection (WOSCC) database. Bibliographic information, such as authorship, country, citation frequency, interactive...
Abstract Background While previous genome-wide association studies (GWAS) have identified multiple risk variants for migraine, there is a lack of evidence about how these contribute to the development migraine. We employed an integrative pipeline efficiently transform genetic associations identify causal genes Methods conducted proteome-wide study (PWAS) by combining data from migraine GWAS with proteomic human brain and plasma proteins that may play role in developing also combined novel...
Abstract Peripheral nerve damage does not fully explain the pathogenesis of trigeminal neuralgia (TN). Central nervous system changes can follow dysfunction. We hypothesized that brain white matter and functional connectivity in TN patients were involved pain perception, modulation, cognitive-affective system, motor function; moreover, reorganization correlated with alterations. Twenty left twenty-two healthy controls studied. Diffusion kurtosis imaging was analyzed to extract diffusion...
Aging | doi:10.18632/aging.205444. Jing-Jing Shi, Cheng-Yuan Mao, Ya-Zhou Guo, Yu Fan, Xiao-Yan Hao, Shuang-Jie Li, Jie Tian, Zheng-Wei Hu, Meng-Jie Jia-Di Dong-Rui Ma, Meng-Nan Chun-Yan Zuo, Yuan-Yuan Liang, Yu-Ming Xu, Jian Yang, Chang-He Shi
Gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), is used clinically as first-line therapy in patients with advanced non-small cell lung cancer (NSCLC) EGFR activating mutations, but the inevitable development of acquired resistance limits its efficacy. In up to 30-40% NSCLC cases, mechanism underlying remains unknown. ATP-binding cassette (ABC) transporters are a family membrane proteins that can significantly influence bioavailability numerous drugs, and...
Ulcerative colitis (UC) is a disease with complex pathological mechanisms. We explored the potential molecular mechanisms behind therapeutic functions of Qingzi Zhitong decoction (QZZTD) in treatment UC by network pharmacology and docking. QZZTD formula Chinese traditional medicine consisting 10 herbs. The active ingredients their target genes were obtained from Traditional Medicine Systems Pharmacology Database Analysis Platform database, UC-related GeneCards OMIM databases. A total 138...
Abstract GGC repeat expansion in the 5′ untranslated region (UTR) of NOTCH2NLC is associated with a broad spectrum neurological disorders, especially neuronal intranuclear inclusion disease (NIID). Studies have found that induces formation polyglycine (polyG)-containing protein, which involved inclusions. However, mechanism neurotoxicity induced by repeats unclear. Here, we used NIID patient-specific pluripotent stem cell (iPSC)-derived 3D cerebral organoids (3DCOs) and cellular models to...
Rapid increases in metabolic disorders, such as type 2 diabetes mellitus (T2DM) and hyperlipidemia, are becoming a substantial challenge to worldwide public health. Traditional Chinese medicine has long history abundant experience the treatment of Puerariae lobatae Radix (known Gegen Chinese) is one most prevalent herbs applied treat these diseases. The underlying mechanism by which simultaneously treats however, not been clearly elucidated date. Therefore, we systematically explored...
Neurite orientation dispersion and density imaging (NODDI) is a diffusion model specifically designed for brain magnetic resonance imaging. Despite recent studies suggesting that NODDI modeling might be more sensitive to development than tensor (DTI), these were limited relatively small age range mainly based on the manually operated region of interest analysis. Therefore, this study applied investigate in large sample size 214 subjects ranging ages from 0 14. The whole was automatically...