A5050005682- Thyroid Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Radiomics and Machine Learning in Medical Imaging
- Head and Neck Anomalies
- Social Media in Health Education
- Health Literacy and Information Accessibility
- CAR-T cell therapy research
- AI in cancer detection
- Cancer Immunotherapy and Biomarkers
- Neuroendocrine Tumor Research Advances
- Voice and Speech Disorders
- Misinformation and Its Impacts
- Angiogenesis and VEGF in Cancer
- Cervical Cancer and HPV Research
- S100 Proteins and Annexins
- Tracheal and airway disorders
- Image and Video Quality Assessment
- CRISPR and Genetic Engineering
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Orthopaedic implants and arthroplasty
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Hip and Femur Fractures
Hangzhou First People's Hospital
2011-2025
Zhejiang Chinese Medical University
2022-2025
Westlake University
2024-2025
Zhejiang Normal University
2024
Zhejiang University
2018-2023
Creative Research Enterprises (United States)
2018
Differentiating follicular thyroid adenoma (FTA) from carcinoma (FTC) remains challenging due to similar histological features separate invasion. In this study, we aim develop and validate DNA protein-based classifiers for FTA/FTC differentiation. We collected 2443 samples 1568 patients across 24 centers applied next-generation sequencing, as well discovery targeted proteomics. Machine learning models were developed compared utilizing and/or protein features. The model (AUC 0.899)...
Background The detection rate of thyroid nodules has witnessed a significant surge in recent years, triggering heightened public apprehension. Short video platforms such as TikTok and BiliBili have showed tremendous potential the dissemination health information. There is plethora videos about on BiliBili, but quality reliability concerning remains unknown. Methods On December 3 rd , 2023, top 100 short related to were collected through comprehensive search Chinese. After extracting basic...
Primary hyperparathyroidism (PHPT) is rare during pregnancy. A case of twin pregnancy with three simultaneous parathyroid adenomas at the same time has not been reported. Multiple lesions are difficult to diagnose, as pregnant women who insist upon continuing a able undergo 99mTc-sestamibi scintigraphy, so cases PHPT easily unobserved and often can have serious consequences for patient fetus. Therefore, we reported 28-year-old woman mid-pregnancy twins, had hypercalcemia was eventually...
Objective This study summarizes the anatomical features of superior laryngeal nerve in Chinese to enable rapid location during an operation. Study Design Retrospective analysis data. Setting Hangzhou First People’s Hospital Affiliated Nanjing Medical University. Methods A total 71 embalmed human cadavers (132 heminecks) were examined over 3 months. The length and diameter internal external branches their relationships with different landmarks recorded. Results branch was 23.4 ± 6.9 mm. 47.7...
prognosis, identify clinicopathological characteristics, and determine optimal modalities for cT1N0M0 solitary papillary thyroid carcinoma in the isthmus (PTCI).The clinical data of 124 patients with PTCI from 3 medical centers were analyzed retrospectively. Of these, 32 participants had undergone total thyroidectomy plus unilateral central neck dissection, 36 received bilateral 24 less-than-total dissection. We compared effects different surgical characteristics on prognosis PTCI.There was...
Abstract Purpose The detection rate of thyroid nodules has witnessed a significant surge recently. Short video platforms such as Tiktok and Bilibili show tremendous potential in the dissemination health information. There is plethora videos about on bilibili with uncertain quality reliability. garnering widespread popularity among users. aim study to investigate reliability these videos. Methods On December 3rd 2023, top 100 short related were collected respectively. After extracting basic...
Abstract Objective To investigate the difference between an artificial intelligence (AI) system, fine-needle aspiration (FNA) cytopathology, BRAFV600E mutation analysis and combined method of latter two in thyroid nodule diagnosis. Methods Ultrasound images 490 nodules (378 patients) with postsurgical pathology or twice consistent FNA examination outcomes a half-year interval, which were considered as gold standard, collected analyzed. The diagnostic efficacies AI system FNA-based methods...
Objective To establish human pancreatic cancer xenografts in nude mice, and to investigate the antitumor efficacy of endostatin expressed by replication-competent adenovirus AdTPHre-hE vivo. Methods Pancreatic cells AsPC-1 were injected subcutaneously BALB/c mice xenografts. Tumor growth was observed measured after treatment. Expression detected ELISA assay. The tumors harvested for pathologic examination immunohistochemical staining. Results Tumors grew more slowly group their sizes...
Abstract Objective To investigate the efficacy of ultrasonic nodule to muscle gray scale ratio as a predictive tool for distinguishing between benign and malignant thyroid nodules. Methods A retrospective study was undertaken at First People's Hospital Hangzhou, affiliated with Zhejiang University School Medicine, analyzing ultrasound pathological data patients nodules May 2020 December 2022. The extracted features employed univariate multivariate logistic regression analyses identify...
ABSTRACT Background The BRAFV600E mutations is an important molecular event in the occurrence and development of papillary thyroid carcinoma (PTC). A qualitative detection mutation still insufficient to explain biological behavior PTC. Though quantitative can reflect certain characteristics PTC, its clinical value controversial. We aimed investigate association between ratio alleles clinicopathological parameters PTC patients. Methods Genomic DNA was extracted from specimens obtained 329...
Abstract Background: To evaluate the reliability and diagnostic efficacy of ultrasound grayscale ratio (UGSR) for differentiating papillary thyroid microcarcinomas (PTMC) from micronodular goiters (diameter ≤ 1.0cm).Methods: The data 241 pathologically-confirmed cases patients with 265 PTMC 141 168 were retrospectively reviewed. All underwent outpatient ultrasonic examination preoperative positioning. RADinfo radiograph reading system (Zhejiang RAD Information Technology Co., Ltd., China)...