A5091762266- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Lung Cancer Research Studies
- Management of metastatic bone disease
- Radiomics and Machine Learning in Medical Imaging
- Intracranial Aneurysms: Treatment and Complications
- Medical Imaging Techniques and Applications
- Cancer-related molecular mechanisms research
- Traumatic Brain Injury and Neurovascular Disturbances
- Thyroid Cancer Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Insect Resistance and Genetics
- Prostate Cancer Treatment and Research
- Cerebrovascular and Carotid Artery Diseases
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Brain Metastases and Treatment
- Insect Pest Control Strategies
- Insect and Pesticide Research
- Neurosurgical Procedures and Complications
- Acute Ischemic Stroke Management
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Moyamoya disease diagnosis and treatment
- Cancer Cells and Metastasis
- Nanoplatforms for cancer theranostics
Hangzhou First People's Hospital
2024-2025
First Affiliated Hospital Zhejiang University
2020-2025
Zhejiang University
2016-2025
Zhejiang Chinese Medical University
2023-2025
First Affiliated Hospital of Shantou University Medical College
2022-2024
Shantou University
2022-2024
Zhengzhou University
2020-2023
Energy Research Institute
2022
Huaqiao University
2022
University of Chinese Academy of Sciences
2022
Glioblastoma (GBM) is one of the most prevalent malignant brain tumors with poor prognosis. Increasing evidence has revealed that infiltrating immune cells and other stromal components in tumor microenvironment (TME) are associated prognosis GBM. The aim present study was to identify immune-related genes extracted from TME RNA-sequencing clinical data GBM were downloaded Cancer Genome Atlas (TCGA). Four survival-related identified via Kaplan-Meier survival analysis differentially expressed...
Kidney cancer is a highly lethal cancer, of which the most common type renal cell carcinoma (RCC). The targeted drugs used in treating RCC clinically have lot side effects. Therefore, it urgent to find out effective agents with little toxic effects.The antiproliferation effect chlorogenic acid (CA) was performed using CCK-8 assay. Then, we adopted colony formation assay, Annexin V/PI staining assay and JC-1 mitochondrial membrane potential explore mechanism anticancer CA. We also conducted...
Background: Patients with poor-grade aneurysmal subarachnoid hemorrhage (aSAH), defined as World Federation of Neurosurgical Societies (WFNS) grades IV–V have high rates disability and mortality. The objective this study was to accurately prognosticate the outcomes patients aSAH by developing a new scoring model. Methods: A total 147 in our center were enrolled. Risk variables identified multivariate logistic regression analysis used devise model (total score, 0–9 points). scores estimated...
Radiotherapy is an indispensable modality in comprehensive treatment of breast cancer. However, inherent or acquired radiation resistance tumors compromises the efficacy radiotherapy. Herein, we found that CD146, a unique epithelial-to-mesenchymal transition (EMT) inducer particularly highly expressed triple-negative cancer (TNBC), dramatically induced by ionizing irradiation. Further study demonstrates CD146 promotes tumor cell radioresistance vitro and vivo. Specifically, report underlying...
Internal carotid artery (CA) stenosis is a primary etiological factor for stroke and transient ischemic attack. The severity of arterial significantly impacts patient health treatment decisions. Therefore, we conducted computational fluid dynamics analyses on five arteries (CAs) severe compared them with CAs in the control group. We improved three-element Windkessel model method by pre-calculating constant-pressure outlet simulation first cardiac cycle, which accelerated stability model....
The incidence of thyroid cancer (TC) is increasing annually worldwide, with a growing burden. This study aims to analyze temporal trends in the burden TC by age and sex China globally from 1990 2021, including incidence, prevalence, mortality, disability-adjusted life years (DALYs) rates, predict future trends. We obtained data on 2021 Global Burden Disease (GBD) database. Using Joinpoint regression model, we calculated analyzed age-standardized rate (ASIR), prevalence (ASPR), mortality...
The burden of thyroid cancer (TC) among young people aged 10–24 years has not been systematically studied to date. This study aims analyze the TC globally, regionally, and nationally from 1990 2021. We collected data on incidence, mortality, disability-adjusted life (DALYs) rates for 2021 using Global Burden Disease (GBD) Joinpoint regression analysis, frontier health inequality analysis were employed examine variations changes in across different countries regions. From 2021, global...
Signal transducers and activators of transcription 3 (STAT3) is a central cytoplasmic factor regulates number pathways important in tumorigenesis including cell cycle progression, apoptosis, tumor angiogenesis, invasion metastasis.This study aims to investigate the expression pSTAT3, VEGF VEGF-C pancreatic adenocarcinoma their relations clinicopathological features, angiogenesis prognosis. In present study, microvascular density (MVD) were examined via immunohistochemistry. The information...
Apoptosis of endothelial cells caused by reactive oxygen species plays an important role in ischemia/reperfusion injury after cerebral infarction. Buyang Huanwu Decoction (BYHWD) has been used to treat stroke and stroke-induced disability, however, the mechanism for this treatment remains unknown. In study, we investigated whether BYHWD can protect human umbilical vein (HUVECs) from H2O2-induced apoptosis explored underlying mechanisms. To investigate effect on HUVECs, established a...
Non-small cell lung cancer (NSCLC) is the most common worldwide. MicroRNAs have been shown to be correlated with biological processes of various tumors. In this study, we observed that expression miR-582-5p was lower in NSCLC tissues than para-carcinoma tissues. Ectopic significantly inhibited NCI-H358 proliferation and invasion. Knockdown showed opposite results, growth rate invasive capacity PC-9 cells enhanced. Furthermore, elucidated NOTCH1 a target there an inverse correlation between...
Abstract Purpose: Glioblastoma (GBM) is a highly vascularized tumor with few treatment options after disease recurrence. Here, we report the efficacy and safety of anlotinib hydrochloride plus temozolomide in patients recurrent GBM. Patients Methods: first definite postsurgical progression histologically confirmed GBM preceded by standard radiotherapy chemotherapy were eligible for inclusion. All received (150–200 mg/m2, orally, every day (QD) d1–5/4 wk) (10 mg, QD, d1–14/3 until or...
Buyang Huanwu decoction (BYHWD), an important traditional Chinese medicine (TCM), has been used clinically for centuries the treatment of various diseases. The study aims to explore BYHWD effects on angiogenesis and neuroprotection after cerebral ischemia/reperfusion (CI/R) injury in rats underlying angiogenic roles mechanisms hydrogen peroxide (H2O2) induced oxidative stress human umbilical vein endothelial cells (HUVECs) model.The neurological function were screened by measuring deficits,...
Abstract The blood‐brain barrier (BBB) damage is a momentous pathological process of ischaemic stroke. NADPH oxidases 4 (NOX4) boosts BBB after stroke and its expression can be influenced by microRNAs. This study aimed to probe into whether miR‐92b the regulating NOX4 expression. Here, was lessened in brains rats oxygen‐glucose deprivation (OGD)‐induced brain microvascular endothelial cells (BMECs). In middle cerebral artery occlusion (MCAo) rats, overexpression relieved ameliorated...
Objective: Based on TCGA database, a prediction model for 1-, 3-, and 5-year overall survival rates of gastric cancer (GC) patients was constructed by analyzing the critical risk factors affecting prognosis patients. Method: Clinicopathological features as well gene signature GC were obtained from database. Patients randomly divided into training cohort an internal validation cohort. Independent predictors analyzed univariate multivariate Cox analyses to construct nomogram. The accuracy...
Trastuzumab (Tmab) targeted therapy or its combination with chemotherapy is normally insufficient to elicit a comprehensive therapeutic response owing the inherent acquired drug resistance and systemic toxicity observed in highly invasive HER2-positive breast cancer. In this study, we propose novel approach that integrates photothermal (PTT) chemotherapy, thereby achieving additive synergistic outcomes. We utilize PEGylated two-dimensional black phosphorus (2D BP) as nanoplatform agent load...